INT131265

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPHB3) plasma membrane (EPHB3)
Anatomy Link Frequency
Caco-2 2
EPHB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 1 89.76 High High
Dopamine 83 72.24 Quite High
Potency 2 69.76 Quite High
midbrain 20 63.36 Quite High
Action potential 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
drug abuse 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 7 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Parkinson's Disease 1 5.00 Very Low Very Low Very Low
Nervous System Malformation 1 5.00 Very Low Very Low Very Low
Mucocutaneous Lymph Node Syndrome 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differentiation increased expression of EPHB2 and EPHB3.
Positive_regulation (increased) of Gene_expression (expression) of EPHB3
1) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
Inhibition of N-[methyl-3H]4-phenylpyridinium ([3H]MPP+) uptake by various compounds into Caco-2 cells and into cells (HEK-293 or CHO) that were stably transfected with hOCT1, hOCT2 or hOCT3 was compared.
Positive_regulation (transfected) of Gene_expression (transfected) of HEK-293 in Caco-2
2) Confidence 0.02 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16263091 Disease Relevance 0 Pain Relevance 0.15

General Comments

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