INT131296

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2011
Negated 7
Speculated 4
Reported most in Body
Documents 208
Total Number 212
Disease Relevance 170.10
Pain Relevance 15.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
brain 51
cleavage 9
neuronal 8
neurons 7
hippocampus 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 72 99.96 Very High Very High Very High
ischemia 973 99.78 Very High Very High Very High
Inflammation 2202 99.76 Very High Very High Very High
dexamethasone 16 99.68 Very High Very High Very High
glial activation 228 99.56 Very High Very High Very High
Hippocampus 1132 99.44 Very High Very High Very High
cytokine 929 99.40 Very High Very High Very High
Inflammatory mediators 57 97.00 Very High Very High Very High
cINOD 958 96.40 Very High Very High Very High
agonist 326 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 14085 100.00 Very High Very High Very High
Targeted Disruption 6531 100.00 Very High Very High Very High
Amyloid Plaque 2000 100.00 Very High Very High Very High
Convulsion 180 100.00 Very High Very High Very High
Stress 5606 99.98 Very High Very High Very High
Injury 930 99.96 Very High Very High Very High
Alzheimer's Dementia 4859 99.80 Very High Very High Very High
Cv Unclassified Under Development 814 99.78 Very High Very High Very High
INFLAMMATION 2843 99.76 Very High Very High Very High
Parkinson's Disease 249 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The preserved elevation of BACE1 allows the continued acceleration of ?
Positive_regulation (elevation) of BACE1
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.51 Pain Relevance 0
-dependent translational upregulation of BACE1 in response to behavioral stressors may represent an important molecular mechanism by which environmental factors initiate ?
Positive_regulation (upregulation) of BACE1
2) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.60 Pain Relevance 0.07
Indeed, He et al. have previously demonstrated that RNAi-mediated depletion of GGAs significantly increases endosomal BACE1 levels [239].
Positive_regulation (increases) of BACE1
3) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.87 Pain Relevance 0.07
While other post-translational mechanisms may account for this observed decrease in GGA3, it is tempting to speculate that apoptotic events may play a role in the increase in BACE1 in AD brain, indeed, elevated BACE1 activity may lead to increased A?
Positive_regulation (elevated) of BACE1 in brain associated with disease and apoptosis
4) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.85 Pain Relevance 0.03
As previously indicated, increased BACE1 levels and activity have been reported in both in vitro and in vivo under conditions of altered energy metabolism and cellular stress.
Positive_regulation (increased) of BACE1 associated with stress
5) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.50 Pain Relevance 0
Paradoxically, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [69, 143, 199], implying that a post-transcriptional mechanism may be responsible for the BACE1 increase.
Positive_regulation (increase) of BACE1 in brain associated with targeted disruption and amyloid plaque
6) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.01 Pain Relevance 0.32
Not only did ischemia lead to an elevation in BACE1 protein and activity but data from co-localization experiments indicated that BACE1 immunoreactivity was strongly associated with TUNEL staining, a marker of apoptosis [187].
Positive_regulation (elevation) of BACE1 protein associated with ischemia and apoptosis
7) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.08 Pain Relevance 0.17
Given the competition for APP substrate, it is interesting to note that, in addition to increased BACE1 activity, a study demonstrated that in approximately two thirds of samples studied, ?
Positive_regulation (increased) of BACE1
8) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.68 Pain Relevance 0
In agreement with previous studies indicating that energy inhibition is potentially amyloidogenic [169-171], following acute energy inhibition in vivo we observed a significant elevation in BACE1 protein that appeared to correspond with a significant increase in cerebral A?
Positive_regulation (elevation) of BACE1 protein
9) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.55 Pain Relevance 0
Furthermore, significant increases in BACE1 protein and activity have been observed in the AD brain.
Positive_regulation (increases) of BACE1 protein in brain associated with disease
10) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.70 Pain Relevance 0
Importantly, because the BACE1 increase correlated with amyloid pathology in both Tg models and was observed in both the absence (Tg2576) and presence (5XFAD) of significant neuronal loss, we concluded that BACE1 elevation appeared to be associated with amyloid pathology rather than cell death.
Positive_regulation (elevation) of BACE1 in neuronal associated with targeted disruption, alzheimer's dementia and death
11) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.66 Pain Relevance 0
In the rat ischemia model, this reduction in GGA3 levels was co-ordinated with caspase activation and increased BACE1 protein levels.
Positive_regulation (activation) of BACE1 protein associated with ischemia
12) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.89 Pain Relevance 0.08
levels lead to increased BACE1 mRNA [181].
Positive_regulation (increased) of BACE1 mRNA
13) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 1.08 Pain Relevance 0.40
deposition BACE1 protein levels and activity were increased significantly in AD brain compared to non-demented control brain [134-138].
Positive_regulation (increased) of BACE1 protein in brain associated with disease
14) Confidence 0.69 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.68 Pain Relevance 0
Nevertheless, BACE1 activity is enhanced in lipid microdomains [114] and cholesterol-rich microdomains are critically involved in BACE1 cleavage of APP.
Positive_regulation (enhanced) of BACE1 in cleavage
15) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.70 Pain Relevance 0.03
While it is apparent that BACE1 expression can be tightly regulated at the transcriptional level, in some studies BACE1 mRNA levels in either neurons or astrocytes around amyloid plaques in APP transgenic brain are not elevated [97,100,101], implying that a post-translational mechanism may be responsible for the BACE1 increase.
Neg (not) Positive_regulation (elevated) of BACE1 mRNA in astrocytes associated with targeted disruption and amyloid plaque
16) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.33 Pain Relevance 0.18
In an experimental stroke model used to study the effects of transient cerebral ischemia, ischemia led to an elevation in BACE1 protein and activity, and BACE1 immunoreactivity was strongly associated with TUNEL staining, a marker of apoptosis [229].
Positive_regulation (elevation) of BACE1 protein associated with transient ischemic attack, stroke, ischemia and apoptosis
17) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.41 Pain Relevance 0.18
Importantly, because the BACE1 increase correlated with amyloid pathology in both Tg models and was observed in both the absence (Tg2576) and presence (5XFAD) of significant neuronal loss, we concluded that BACE1 elevation appeared to be associated with amyloid pathology rather than cell death.
Positive_regulation (elevation) of BACE1 in neuronal associated with targeted disruption, alzheimer's dementia and death
18) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 1.02 Pain Relevance 0
While our data indicates that the BACE1 elevation in AD is actively involved in AD progression and may be detected prior to the appearance of overt neurodegeneration [97], increases in BACE1 activity have also been demonstrated in vivo occurring in response to the induction of apoptosis; an event associated with the later stages of neurodegeneration [136].
Positive_regulation (increases) of BACE1 associated with apoptosis
19) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.80 Pain Relevance 0.07
levels lead to increased BACE1 mRNA [88].
Positive_regulation (increased) of BACE1 mRNA
20) Confidence 0.69 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.60 Pain Relevance 0.63

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