INT1313

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Context Info
Confidence 0.35
First Reported 1977
Last Reported 1993
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pomc, Prl) signal transduction (Pomc) generation of precursor metabolites and energy (Pomc)
extracellular space (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
neurons 1
Pomc (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 27 100.00 Very High Very High Very High
Dynorphin 8 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
Dopamine 11 99.34 Very High Very High Very High
opiate 7 99.26 Very High Very High Very High
Opioid 3 98.72 Very High Very High Very High
Nicotine 4 95.28 Very High Very High Very High
agonist 8 93.64 High High
antagonist 3 88.04 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opiate receptor subtype involvement in the stimulation of prolactin release by beta-endorphin in female rats.
beta-endorphin Positive_regulation (stimulation) of prolactin associated with opiate
1) Confidence 0.35 Published 1993 Journal Neuroendocrinology Section Title Doc Link 8413824 Disease Relevance 0 Pain Relevance 0.40
These results suggest that the central cholinergic system exertes an inhibitory influence on the prolactin release induced by morphine or beta-endorphin and the cholinergic inhibition is not mediated via catecholaminergic neurons.
beta-endorphin Positive_regulation (induced) of prolactin in neurons associated with morphine
2) Confidence 0.24 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 503252 Disease Relevance 0 Pain Relevance 0.57
Pilocarpine also inhibited the release of prolactin induced by beta-endorphin or metoclopramide without affecting the basal and haloperidol-stimulated serum prolactin levels.
beta-endorphin Positive_regulation (induced) of prolactin
3) Confidence 0.24 Published 1979 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 503252 Disease Relevance 0 Pain Relevance 0.50
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
beta-endorphin Positive_regulation (induce) of PRL associated with dynorphin, enkephalin and morphine
4) Confidence 0.18 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Diurnal variations of the effectivity of beta-endorphin (beta-End), dynorphin (DYN), Met-enkephalin (Met-Enk), D-Met2-Pro5-enkephalinamide (D-Met-Pro-Enk) and morphine to induce prolactin (PRL) and adrenocorticotropin (ACTH)/corticosterone (CS) release in intact and adrenalectomized rats have been examined.
beta-endorphin Positive_regulation (induce) of prolactin associated with dynorphin, enkephalin and morphine
5) Confidence 0.18 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2892145 Disease Relevance 0 Pain Relevance 0.57
Stimulation in vivo of the secretion of prolactin and growth hormone by beta-endorphin.
beta-endorphin Positive_regulation (Stimulation) of prolactin associated with narcan
6) Confidence 0.10 Published 1977 Journal Endocrinology Section Title Doc Link 187406 Disease Relevance 0 Pain Relevance 0.53
Infusion of DA had no effect on the release of PRL induced by intracerebroventricularly administered beta-endorphin.
beta-endorphin Neg (no) Positive_regulation (induced) of PRL associated with dopamine
7) Confidence 0.10 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6320031 Disease Relevance 0 Pain Relevance 1.06

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