INT131332

Context Info Confidence 0.58 First Reported 2005 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 7 Total Number 8 Disease Relevance 1.25 Pain Relevance 2.35

ATPase activity (Abcc2)

Anatomy Link Frequency bile duct 2 liver 2 Abcc2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 28 100.00 Paracetamol 38 99.90 anesthesia 4 5.00 Opioid 2 5.00

Disease Link Frequency Relevance Heat Sprains And Strains 2 98.80 Hepatotoxicity 10 84.16 Gallstones 4 80.44 Stress Incontinence 2 67.80 Congenital Anomalies 2 66.68 Toxicity 4 27.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls.

Negative_regulation (decreased) of Gene_expression (expression) of multidrug resistance-associated protein 2

1) Confidence 0.58 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.16 Pain Relevance 0.16

Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls.

Negative_regulation (decreased) of Gene_expression (expression) of Mrp2

2) Confidence 0.42 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17686906 Disease Relevance 0.16 Pain Relevance 0.16

The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2).

Negative_regulation (reduced) of Neg (lacking) Gene_expression (lacking) of multidrug resistance-associated protein 2 associated with paracetamol

3) Confidence 0.41 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16271353 Disease Relevance 0.40 Pain Relevance 0.56

The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2).

Negative_regulation (reduced) of Neg (lacking) Gene_expression (lacking) of Mrp2 associated with paracetamol

4) Confidence 0.41 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16271353 Disease Relevance 0.40 Pain Relevance 0.56

We conclude that induced expression of basolateral Mrp3 by EE may represent a compensatory mechanism to prevent intracellular accumulation of common Mrp substrates, either endogenous or exogenous, due to reduced expression and activity of apical Mrp2.

Negative_regulation (reduced) of Gene_expression (expression) of Mrp2

5) Confidence 0.40 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.48

Western blotting analysis revealed decreased Mrp2 (-41%) and increased Mrp3 (+200%) expression by EE.

Negative_regulation (decreased) of Gene_expression (expression) of Mrp2

6) Confidence 0.40 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16554369 Disease Relevance 0 Pain Relevance 0.40

Cao et al. (2002) reported that the hepatic expression of multidrug resistance-associated protein 2 (Mrp2), which excretes chemical conjugates such as glucuronide into bile duct, is reduced during pregnancy in the rat.

Negative_regulation (reduced) of Gene_expression (expression) of Mrp2 in bile duct associated with bile

7) Confidence 0.37 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.13 Pain Relevance 0.05

In maternal liver, we detected Mrp2, Oatp1a4, and Oatp1b2 expression (Figure 4A).

Negative_regulation (detected) of Gene_expression (expression) of Mrp2 in liver

8) Confidence 0.27 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

General Comments

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