INT131332
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls. | |||||||||||||||
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Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls. | |||||||||||||||
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The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2). | |||||||||||||||
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The biliary excretion of acetaminophen (APAP) is reduced in transport deficient (TR-) hyperbilirubinemic rats lacking the multidrug resistance-associated protein 2 (Mrp2). | |||||||||||||||
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We conclude that induced expression of basolateral Mrp3 by EE may represent a compensatory mechanism to prevent intracellular accumulation of common Mrp substrates, either endogenous or exogenous, due to reduced expression and activity of apical Mrp2. | |||||||||||||||
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Western blotting analysis revealed decreased Mrp2 (-41%) and increased Mrp3 (+200%) expression by EE. | |||||||||||||||
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Cao et al. (2002) reported that the hepatic expression of multidrug resistance-associated protein 2 (Mrp2), which excretes chemical conjugates such as glucuronide into bile duct, is reduced during pregnancy in the rat. | |||||||||||||||
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In maternal liver, we detected Mrp2, Oatp1a4, and Oatp1b2 expression (Figure 4A). | |||||||||||||||
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General Comments
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