INT13134

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1982
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.73
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRA2C) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C)
cell-cell signaling (ADRA2C) cytoplasm (ADRA2C) signal transducer activity (ADRA2C)
Anatomy Link Frequency
digestive tract 1
platelets 1
ADRA2C (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 25 100.00 Very High Very High Very High
Opioid 4 99.90 Very High Very High Very High
spastic colon 1 97.32 Very High Very High Very High
antagonist 10 97.20 Very High Very High Very High
noradrenaline 8 94.12 High High
Clonidine 10 91.92 High High
opioid receptor 8 89.60 High High
Dismenorea 1 82.72 Quite High
Potency 7 82.40 Quite High
Inflammation 5 79.76 Quite High
Disease Link Frequency Relevance Heat
Constipation 1 99.00 Very High Very High Very High
Functional Bowel Disorder 1 97.32 Very High Very High Very High
Ileus 2 90.08 High High
Dysmenorrhea 1 82.72 Quite High
INFLAMMATION 5 79.76 Quite High
Enteropathy 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Non-linear regression analysis showed that agonists bind to two affinity states of the alpha 2-adrenergic receptor, a high and a low affinity state.
alpha 2-adrenergic Binding (bind) of associated with agonist
1) Confidence 0.46 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6127987 Disease Relevance 0 Pain Relevance 0.51
GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.
alpha 2-adrenergic Binding (binding) of in platelets associated with agonist
2) Confidence 0.36 Published 1982 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 6127987 Disease Relevance 0 Pain Relevance 0.40
It is concluded that GTP regulates binding of alpha 2-adrenergic agonists at the human alpha 2-adrenergic receptor.
alpha 2-adrenergic Binding (binding) of associated with agonist
3) Confidence 0.34 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6127987 Disease Relevance 0 Pain Relevance 0.42
Analysing inhibitory activity of imidazol(in)es one notes the drugs commonly assumed to interact with alpha 2 adrenoceptor among the most potent inhibitors, and those classified as alpha 1 adrenoceptor agonists among the less active agents. 8.
alpha 2 adrenoceptor Binding (interact) of associated with agonist
4) Confidence 0.33 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1662170 Disease Relevance 0 Pain Relevance 0.14
It is concluded that GTP regulates binding of alpha 2-adrenergic agonists at the human alpha 2-adrenergic receptor.
alpha 2-adrenergic Binding (binding) of associated with agonist
5) Confidence 0.30 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6127987 Disease Relevance 0 Pain Relevance 0.42
In this study, we introduce a new approach to mapping of the binding site crevice of the human alpha2A-AR.
alpha2A-AR Binding (binding) of
6) Confidence 0.26 Published 1998 Journal Mol. Pharmacol. Section Abstract Doc Link 9495800 Disease Relevance 0 Pain Relevance 0.12
Progesterone prevents linkage of rabbit myometrial alpha 2-adrenergic receptors to inhibition of adenylate cyclase.
alpha 2-adrenergic Binding (linkage) of
7) Confidence 0.26 Published 1989 Journal Am. J. Obstet. Gynecol. Section Title Doc Link 2540655 Disease Relevance 0.08 Pain Relevance 0.23
In addition, genetic investigations have highlighted significant associations of alpha2-adrenoceptor gene polymorphisms with constipation and somatic symptoms in functional disorders of lower digestive tract.
alpha2-adrenoceptor Binding (associations) of in digestive tract associated with constipation
8) Confidence 0.25 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17618014 Disease Relevance 0.64 Pain Relevance 0.25
In delta-i3L-expressing cells, the peptide blocked high-affinity agonist binding to both the delta- and the mu-opioid (delta-OR and mu-OR) and attenuated opioid and alpha2-adrenergic receptor (alpha2AR)-dependent [35S]guanosine-5'-O-(3-thio)triphosphate binding.
alpha2AR Binding (binding) of associated with agonist and opioid
9) Confidence 0.04 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.45
In delta-i3L-expressing cells, the peptide blocked high-affinity agonist binding to both the delta- and the mu-opioid (delta-OR and mu-OR) and attenuated opioid and alpha2-adrenergic receptor (alpha2AR)-dependent [35S]guanosine-5'-O-(3-thio)triphosphate binding.
alpha2-adrenergic receptor Binding (binding) of associated with agonist and opioid
10) Confidence 0.04 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16160084 Disease Relevance 0 Pain Relevance 0.45
Agmatine displayed preferential affinity for I1 receptors, with both high (H) and low (L) affinity components; the rank order was I1(human)(H) > I1(bovine)(H) > I2b = I1(human)(L) = I1(bovine) (L) = alpha-2A = alpha-2B = alpha-2C.
alpha-2C Binding (affinity) of
11) Confidence 0.01 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7853171 Disease Relevance 0 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox