INT131351

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2006
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 11
Disease Relevance 13.72
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
ventricle 6
head 6
plasma 2
chest 2
BNP 2
Nppb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cva 50 97.16 Very High Very High Very High
ischemia 40 96.30 Very High Very High Very High
Angina 20 89.76 High High
anesthesia 1 87.72 High High
Arthritis 10 87.36 High High
isoflurane 1 87.28 High High
Versed 1 86.84 High High
fibrosis 2 71.52 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
beta blocker 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 90 100.00 Very High Very High Very High
Pulmonary Disease 90 99.96 Very High Very High Very High
Obesity 180 99.80 Very High Very High Very High
Myocardial Infarction 580 99.40 Very High Very High Very High
Coronary Artery Disease 30 99.24 Very High Very High Very High
Systemic Sclerosis 40 98.96 Very High Very High Very High
Stress 30 98.54 Very High Very High Very High
Dyspnea 140 97.60 Very High Very High Very High
Cv General 3 Under Development 10 97.16 Very High Very High Very High
Cv Unclassified Under Development 90 96.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An important consideration in patients with pulmonary disease is involvement of the right ventricle as a consequence of their pulmonary disease: since NT-proBNP is produced everywhere cardiomyocytes are present it is well known that cardiomyocytes in the right ventricle produce NT-proBNP to a meaningful degree, particularly when stretched.67 Therefore, although the concentrations are usually lower, NT-proBNP can be elevated in with patients with increased right ventricular pressures, such as in pulmonary embolism (PE) or pulmonary arterial hypertension (PAH).38,68 In patients with PE, echocardiographic studies have confirmed that NT-proBNP concentrations correlate with echocardiographic and invasive measured parameters of right ventricular dysfunction.68–70 Also, Kucher et al. have shown that elevated concentrations of NT-proBNP correlate with adverse clinical outcome in patients with PE,71 which makes NT-proBNP not only a predictor of prognosis in these patients, but also a potential tool in therapy decision making (i.e. which patient should receive thrombolytic therapy).
Positive_regulation (present) of Gene_expression (produced) of NT-proBNP in ventricle associated with pulmonary embolism, pulmonary hypertension, pulmonary disease, right ventricular dysfunction and cva
1) Confidence 0.50 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.91 Pain Relevance 0.17
An important consideration in patients with pulmonary disease is involvement of the right ventricle as a consequence of their pulmonary disease: since NT-proBNP is produced everywhere cardiomyocytes are present it is well known that cardiomyocytes in the right ventricle produce NT-proBNP to a meaningful degree, particularly when stretched.67 Therefore, although the concentrations are usually lower, NT-proBNP can be elevated in with patients with increased right ventricular pressures, such as in pulmonary embolism (PE) or pulmonary arterial hypertension (PAH).38,68 In patients with PE, echocardiographic studies have confirmed that NT-proBNP concentrations correlate with echocardiographic and invasive measured parameters of right ventricular dysfunction.68–70 Also, Kucher et al. have shown that elevated concentrations of NT-proBNP correlate with adverse clinical outcome in patients with PE,71 which makes NT-proBNP not only a predictor of prognosis in these patients, but also a potential tool in therapy decision making (i.e. which patient should receive thrombolytic therapy).
Positive_regulation (since) of Gene_expression (produced) of NT-proBNP in ventricle associated with pulmonary embolism, pulmonary hypertension, pulmonary disease, right ventricular dysfunction and cva
2) Confidence 0.50 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.90 Pain Relevance 0.16
An important consideration in patients with pulmonary disease is involvement of the right ventricle as a consequence of their pulmonary disease: since NT-proBNP is produced everywhere cardiomyocytes are present it is well known that cardiomyocytes in the right ventricle produce NT-proBNP to a meaningful degree, particularly when stretched.67 Therefore, although the concentrations are usually lower, NT-proBNP can be elevated in with patients with increased right ventricular pressures, such as in pulmonary embolism (PE) or pulmonary arterial hypertension (PAH).38,68 In patients with PE, echocardiographic studies have confirmed that NT-proBNP concentrations correlate with echocardiographic and invasive measured parameters of right ventricular dysfunction.68–70 Also, Kucher et al. have shown that elevated concentrations of NT-proBNP correlate with adverse clinical outcome in patients with PE,71 which makes NT-proBNP not only a predictor of prognosis in these patients, but also a potential tool in therapy decision making (i.e. which patient should receive thrombolytic therapy).
Positive_regulation (everywhere) of Gene_expression (produced) of NT-proBNP in ventricle associated with pulmonary embolism, pulmonary hypertension, pulmonary disease, right ventricular dysfunction and cva
3) Confidence 0.50 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.90 Pain Relevance 0.16
Despite the potential differences and analytical concerns, recent head-to-head comparisons show that BNP correlates as well as NT-proBNP with clinical variables in patients with HF, indicating that most of the results of the BNP and NT-proBNP studies are generally transposable.29–31

NT-proBNP: Diagnostic in Dyspnea

Positive_regulation (results) of Gene_expression (studies) of BNP in head associated with dyspnea and myocardial infarction
4) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.50 Pain Relevance 0
Despite the potential differences and analytical concerns, recent head-to-head comparisons show that BNP correlates as well as NT-proBNP with clinical variables in patients with HF, indicating that most of the results of the BNP and NT-proBNP studies are generally transposable.29–31

NT-proBNP: Diagnostic in Dyspnea

Positive_regulation (well) of Gene_expression (correlates) of BNP in head associated with dyspnea and myocardial infarction
5) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.41 Pain Relevance 0
Importantly, a high long-term mortality rate (61%) was observed in patients in whom plasma NT-proBNP levels increased by at least 50% during the follow-up period, while the mortality rate was significantly lower among other patients (12%; p< 0.001).72
Positive_regulation (increased) of Gene_expression (levels) of NT-proBNP in plasma
6) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.95 Pain Relevance 0.13
Since in coronary ischemia (including both stable and unstable angina as well as acute myocardial infarction [MI]), myocardial wall stress increases, and variable reductions in LVEF may also occur, the possible role of NT-proBNP testing for evaluation of ischemic heart disease has also been studied.102,103 Seminal studies found indeed that NT-proBNP was a potential useful diagnostic and prognostic marker in MI.104,105 Jernberg and colleagues also found in 775 patients admitted for acute chest pain without ST elevations that the patients in the 2nd, 3rd, and 4th quartile had a relative risk of subsequent death of 4.2, 10.7 and 26.6 when compared to the lowest quartile.106 Several studies have confirmed that NT-proBNP is an independent predictor of mortality in patients suffering from an acute coronary syndrome (ACS) and moreover, even a stronger predictor for mortality than troponin testing in this setting, regardless of any signs of HF.105,107–110
Spec (possible) Positive_regulation (role) of Gene_expression (testing) of NT-proBNP in chest associated with stress, acute coronary syndrome, angina, coronary artery disease, ischemia, cva, myocardial infarction and death
7) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.17 Pain Relevance 0.19
Despite the potential differences and analytical concerns, recent head-to-head comparisons show that BNP correlates as well as NT-proBNP with clinical variables in patients with HF, indicating that most of the results of the BNP and NT-proBNP studies are generally transposable.29–31

NT-proBNP: Diagnostic in Dyspnea

Positive_regulation (results) of Gene_expression (studies) of NT-proBNP in head associated with dyspnea and myocardial infarction
8) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 0.50 Pain Relevance 0
Indeed, a small study by Allonore et al. performed in 40 patients with systemic sclerosis suggests that NT-proBNP can be used as a screening tool for the early stage of PAH, when clinical symptoms are not present yet.73

NT-proBNP and Obesity

Neg (not) Positive_regulation (yet.73) of Neg (not) Gene_expression (present) of NT-proBNP associated with pulmonary hypertension, obesity and systemic sclerosis
9) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.81 Pain Relevance 0.04
Indeed, a small study by Allonore et al. performed in 40 patients with systemic sclerosis suggests that NT-proBNP can be used as a screening tool for the early stage of PAH, when clinical symptoms are not present yet.73

NT-proBNP and Obesity

Positive_regulation (tool) of Gene_expression (stage) of NT-proBNP associated with pulmonary hypertension, obesity and systemic sclerosis
10) Confidence 0.44 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.89 Pain Relevance 0.04
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Positive_regulation (increased) of Gene_expression (expression) of BNP in BNP
11) Confidence 0.38 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.79 Pain Relevance 0.24

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