INT131359

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 40
Total Number 46
Disease Relevance 22.43
Pain Relevance 7.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 54
lymphocytes 4
lymph nodes 3
RAG 2
Th17 cells 2
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 717 100.00 Very High Very High Very High
Morphine 12 99.98 Very High Very High Very High
Infliximab 15 99.78 Very High Very High Very High
rheumatoid arthritis 584 99.56 Very High Very High Very High
Arthritis 185 98.32 Very High Very High Very High
tolerance 95 97.32 Very High Very High Very High
Inflammation 601 95.32 Very High Very High Very High
opioid receptor 2 93.88 High High
Paracetamol 7 93.24 High High
methotrexate 30 90.24 High High
Disease Link Frequency Relevance Heat
Disease 476 100.00 Very High Very High Very High
Cytomegalovirus Infection 98 100.00 Very High Very High Very High
Infection 353 99.98 Very High Very High Very High
Gastritis 4 99.98 Very High Very High Very High
Sprains And Strains 157 99.78 Very High Very High Very High
Hypersensitivity Pneumonitis 70 99.76 Very High Very High Very High
Rheumatoid Arthritis 589 99.56 Very High Very High Very High
Respiratory Syncytial Virus 94 99.24 Very High Very High Very High
Diabetes Mellitus 303 98.48 Very High Very High Very High
Arthritis 167 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (elevated) of Gene_expression (expression) of CD4 in T cells
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.33 Pain Relevance 0.19
Adaptive transfer of SOCS3Tg-CD4(+) T cells into T and B cell-deficient RAG-2(-/-) mice resulted in an exacerbated liver injury relative to the control.
Positive_regulation (transfer) of Gene_expression (transfer) of CD4 in RAG associated with injury
2) Confidence 0.49 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17339476 Disease Relevance 0.89 Pain Relevance 0.64
We found that the general patterns of CD4+ T cell percentages (Figure 2A) are somewhat similar to those of CD8+ T cells (Figure 2B) during the induction and expression of ACAID.
Positive_regulation (induction) of Gene_expression (expression) of CD4 in T cells
3) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.23 Pain Relevance 0.03
For both of these vaccines, protection was found to be dependent upon CD4+ T cells producing IFN-?
Positive_regulation (upon) of Gene_expression (producing) of CD4 in T cells
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2874006 Disease Relevance 0.59 Pain Relevance 0
Since the MR1 mAb targets the interaction between CD4+ T cells and APCs, we next analyzed its effect on transferred HNT CD4+ T cells.
Spec (analyzed) Positive_regulation (transferred) of Gene_expression (transferred) of CD4 in MR1
5) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.07 Pain Relevance 0
The isotype control for both cytokines is also shown for the CD4+CD25+ population. b Upon adoptive transfer of CD4+CD25+ cells from protected mice, some (n?
Positive_regulation (transfer) of Gene_expression (transfer) of CD4 associated with cytokine
6) Confidence 0.43 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.09
Interestingly, as shown in Fig. 6a, upon in vitro re-stimulation with plate-bound anti-CD3 and soluble anti-CD28, CD4+CD25+ and CD4+CD25?
Positive_regulation (upon) of Gene_expression (shown) of CD4
7) Confidence 0.43 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.38 Pain Relevance 0.09
The isotype control for both cytokines is also shown for the CD4+CD25+ population. b Upon adoptive transfer of CD4+CD25+ cells from protected mice, some (n?
Positive_regulation (shown) of Gene_expression (transfer) of CD4 associated with cytokine
8) Confidence 0.43 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.10
The isotype control for both cytokines is also shown for the CD4+CD25+ population. b Upon adoptive transfer of CD4+CD25+ cells from protected mice, some (n?
Positive_regulation (transfer) of Gene_expression (transfer) of CD4 associated with cytokine
9) Confidence 0.43 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.10
The isotype control for both cytokines is also shown for the CD4+CD25+ population. b Upon adoptive transfer of CD4+CD25+ cells from protected mice, some (n?
Positive_regulation (shown) of Gene_expression (transfer) of CD4 associated with cytokine
10) Confidence 0.43 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.10
In the present study, infestation with the metastriate tick, D. andersoni, induced CD4+ T cell expression of IL-4 at levels comparable to that stimulated by feeding of I. scapularis nymphs [22].
Positive_regulation (induced) of Gene_expression (expression) of CD4 in T cell
11) Confidence 0.42 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.16 Pain Relevance 0.13
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (elevated) of Gene_expression (expression) of CD4 in T cells
12) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.33 Pain Relevance 0.19
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (elevated) of Gene_expression (expression) of CD4 in T cells
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.66 Pain Relevance 0.18
In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.
Positive_regulation (mean) of Gene_expression (expression) of CD4 in T cells
14) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (mean) of Gene_expression (expression) of CD4 in T cells
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.32 Pain Relevance 0.19
As shown in figure 4e, repetitive PTx treatment gradually elevated the frequency of splenic CD4+CD25+FoxP3+ Treg as well as the mean FoxP3 expression of CD4+CD25+ T cells, starting as early as 3 weeks after initiation of PTx treatment.
Positive_regulation (elevated) of Gene_expression (expression) of CD4 in T cells
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.33 Pain Relevance 0.19
In addition, we studied whether vitamin D3 negatively regulate the expression of IL-6R to inhibit TH17 differentiation but we did not see any significant differences in the IL-6R expression of CD4+ T cells after co-culture with IL-6, TGF-?
Positive_regulation (with) of Gene_expression (expression) of CD4 in T cells
17) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.46 Pain Relevance 0.12
The numbers of CD4+ and CD8+ T cells were increased in BALF of Fc?
Positive_regulation (increased) of Gene_expression (numbers) of CD4 in T cells
18) Confidence 0.40 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.68 Pain Relevance 0.07
Nasal vaccination with N SRS followed by RSV challenge results in the presence of activated CD4+ and CD8+ lymphocytes in airways
Positive_regulation (activated) of Gene_expression (lymphocytes) of CD4 in lymphocytes associated with respiratory syncytial virus
19) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.33 Pain Relevance 0.08
Spleen-derived CD4+ T cells secreted significant amounts of IFN-?
Positive_regulation (derived) of Gene_expression (amounts) of CD4 in T cells
20) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.48 Pain Relevance 0.05

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