INT13137

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 0
Pain Relevance 6.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Kcnk4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 27 99.98 Very High Very High Very High
Morphine 48 99.80 Very High Very High Very High
opioid receptor 16 99.76 Very High Very High Very High
Buprenorphine 2 97.84 Very High Very High Very High
narcan 10 96.68 Very High Very High Very High
Enkephalin 3 87.80 High High
Dynorphin 3 81.40 Quite High
antagonist 13 75.68 Quite High
cINOD 1 46.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 1 46.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Though KT-90 had nonselectively high affinities to mu-, kappa- and delta-receptors, affinity of KT-90 to sigma-receptors was lower than those to the other three receptors. 3.
KT-90 Binding (affinity) of
1) Confidence 0.48 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1662176 Disease Relevance 0 Pain Relevance 0.13
Affinity of KT-90 to sigma-receptors was 1000 times lower than that of buprenorphine.
KT-90 Binding (Affinity) of associated with buprenorphine
2) Confidence 0.35 Published 1991 Journal Gen. Pharmacol. Section Abstract Doc Link 1662176 Disease Relevance 0 Pain Relevance 0.14
Analgesic activities of KT-89 and KT-90 were 6 and 10 times as potent as morphine in an acetic acid-induced writhing test, and 4 and 5 times as potent in a pressure test. 6.
KT-90 Binding (activities) of associated with analgesic and morphine
3) Confidence 0.31 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2165960 Disease Relevance 0 Pain Relevance 0.99
Analgesic activities of N-cyclopropylmethyl derivatives of (-)-6 beta-acetylthionormorphine, KT-89 and KT-90 and their interactions with opioid receptors were studied. 2.
KT-90 Binding (interactions) of associated with analgesic and opioid receptor
4) Confidence 0.31 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2165960 Disease Relevance 0 Pain Relevance 0.45
Analgesic activities of N-cyclopropylmethyl derivatives of (-)-6 beta-acetylthionormorphine, KT-89 and KT-90 and their interactions with opioid receptors were studied. 2.
KT-89 Binding (interactions) of associated with analgesic and opioid receptor
5) Confidence 0.31 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2165960 Disease Relevance 0 Pain Relevance 0.45
Analgesic activities of KT-89 and KT-90 were about 6 and 10 times as potent as morphine in an acetic acid-induced writhing test and about 4 and 5 times as potent as in a pressure test. 4.
KT-89 Binding (activities) of associated with analgesic and morphine
6) Confidence 0.30 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2177430 Disease Relevance 0 Pain Relevance 1.21
Analgesic activities of KT-89 and KT-90 were about 6 and 10 times as potent as morphine in an acetic acid-induced writhing test and about 4 and 5 times as potent as in a pressure test. 4.
KT-90 Binding (activities) of associated with analgesic and morphine
7) Confidence 0.30 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2177430 Disease Relevance 0 Pain Relevance 1.22
Some pharmacological properties of newly synthesized derivatives of (-)-6 beta-acetylthionormorphine, AcS-morphine (KT-88), KT-89 and KT-90 and their interactions with opioid receptors were studied. 2.
KT-90 Binding (interactions) of associated with opioid receptor and morphine
8) Confidence 0.28 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2177430 Disease Relevance 0 Pain Relevance 0.90
Some pharmacological properties of newly synthesized derivatives of (-)-6 beta-acetylthionormorphine, AcS-morphine (KT-88), KT-89 and KT-90 and their interactions with opioid receptors were studied. 2.
KT-89 Binding (interactions) of associated with opioid receptor and morphine
9) Confidence 0.28 Published 1990 Journal Gen. Pharmacol. Section Abstract Doc Link 2177430 Disease Relevance 0 Pain Relevance 0.90
These findings clearly demonstrate that the KT-PB interaction in the rat is a PB concentration-dependent process.
KT-PB Binding (interaction) of
10) Confidence 0.08 Published 1993 Journal J Pharm Sci Section Abstract Doc Link 8450425 Disease Relevance 0 Pain Relevance 0

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