INT131373

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.78
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDRG1) plasma membrane (NDRG1) nucleus (NDRG1)
cytoplasm (NDRG1)
Anatomy Link Frequency
B-cell 2
sensory neurons 1
neurons 1
satellite cell 1
NDRG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 60 97.40 Very High Very High Very High
Thermal hyperalgesia 4 89.88 High High
qutenza 47 89.64 High High
Sciatic nerve 54 86.00 High High
Peripheral nerve injury 9 85.08 High High
calcitonin gene related peptide 18 82.08 Quite High
c fibre 15 80.28 Quite High
ketamine 2 67.44 Quite High
Inflammatory mediators 5 66.12 Quite High
cINOD 2 62.64 Quite High
Disease Link Frequency Relevance Heat
Leukemia 2 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 329 99.76 Very High Very High Very High
Breast Cancer 60 99.76 Very High Very High Very High
Pain 45 97.40 Very High Very High Very High
Injury 31 90.72 High High
Immunotherapy Of Cancer 1 90.72 High High
Hyperalgesia 4 89.88 High High
Apoptosis 28 89.32 High High
Nervous System Injury 24 85.16 High High
Cancer 42 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, N-myc gene 1 (rtp), promyelocytic leukemia (pml), and nuclear factor of kappa-light polypeptide gene enhancer in B-cell 3 and p65 [avian (rel A)] were up-regulated.
Positive_regulation (up-regulated) of rtp in B-cell associated with leukemia
1) Confidence 0.67 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 16273229 Disease Relevance 0.58 Pain Relevance 0.06
However, N-myc gene 1 (rtp), promyelocytic leukemia (pml), and nuclear factor of kappa-light polypeptide gene enhancer in B-cell 3 and p65 [avian (rel A)] were up-regulated.
Positive_regulation (up-regulated) of N-myc gene 1 in B-cell associated with leukemia
2) Confidence 0.42 Published 2005 Journal Int. J. Oncol. Section Abstract Doc Link 16273229 Disease Relevance 0.58 Pain Relevance 0.06
The average costs per patient compared to the costs of the G-DRG calculation sample of the MDC 19 are presented in table 4 (Tab. 4).
Positive_regulation (presented) of DRG
3) Confidence 0.26 Published 2004 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736487 Disease Relevance 0.23 Pain Relevance 0
WalBC cells exhibited expression of known markers of basal invasive human breast cancers as well as increased KRT17, KRT 14 and KRT 19, DSP, s100A4, NDRG-1, ANXA1, TK1 and AQP3 gene expression and decreased gene expression of TIMP3, VIM and TAGLN.
Positive_regulation (increased) of NDRG-1 associated with breast cancer
4) Confidence 0.12 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2263075 Disease Relevance 0.87 Pain Relevance 0
104 fold higher than that (1 nM) inducing TRPV1-dependent Ca2+-cytotoxicity in bona fide DRG sensory neurons [5] and ?
Positive_regulation (inducing) of DRG in sensory neurons
5) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566593 Disease Relevance 0.13 Pain Relevance 0.25
Using a phospho-specific antibody to detect the activated (phosphorylated) form of c-Jun (p-c-Jun) (Seijffers et al., 2006) we found there to be no significant upregulation of the protein in DRG from HIV-1 gp120 treated animals as compared to sham animals (Fig. 7A, b and Table 2).
Neg (no) Positive_regulation (upregulation) of DRG associated with acquired immune deficiency syndrome or hiv infection
6) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.48 Pain Relevance 0.20
However, the expression of galanin, NPY; the satellite cell marker, GFAP and the macrophage marker, CD68, did increase in the DRG, all of which are features of models of nerve-lesion associated pain (Ma and Bisby, 1998; Wynick et al., 2001).
Positive_regulation (increase) of DRG in satellite cell associated with pain
7) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 1.18 Pain Relevance 0.38
At 7 and 14 days following perineural HIV-1 gp120 there was no significant increase in the percentage of GAP-43-IR neurons in the DRG ipsilateral to HIV-1 gp120 treatment as compared to contralateral DRG or DRG ipsilateral to sham treatment (Table 1, Fig. 7A, d).
Neg (no) Positive_regulation (increase) of DRG in neurons associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.01 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.72 Pain Relevance 0.12
The number of previous captures appeared to increase induction time (although sample size was admittedly low for animals immobilized more than twice), suggesting a decrease in sensitivity to the chemical when first introduced into the bloodstream, even up to 2–3 weeks later.
Positive_regulation (increase) of induction
9) Confidence 0.00 Published 2006 Journal BMC Vet Res Section Body Doc Link PMC1435748 Disease Relevance 0 Pain Relevance 0.03

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