INT131378

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 35
Disease Relevance 33.98
Pain Relevance 5.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
PSC 1
extracellular matrix 1
body 1
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1035 100.00 Very High Very High Very High
Cannabinoid receptor 36 98.36 Very High Very High Very High
dexamethasone 1 93.52 High High
COX-2 inhibitor 12 92.72 High High
Cannabinoid 52 91.84 High High
antagonist 50 89.44 High High
Endocannabinoid 48 89.00 High High
metalloproteinase 32 87.84 High High
cINOD 4 87.20 High High
Inflammation 39 86.48 High High
Disease Link Frequency Relevance Heat
Cirrhosis 1102 100.00 Very High Very High Very High
Fibrosis 696 100.00 Very High Very High Very High
Hepatitis C Virus Infection 544 100.00 Very High Very High Very High
Neutropenia 455 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 416 100.00 Very High Very High Very High
Boutonneuse Fever 82 100.00 Very High Very High Very High
Fever 67 99.80 Very High Very High Very High
Uterine Fibroids 120 99.46 Very High Very High Very High
Primary Sclerosing Cholangitis 88 99.14 Very High Very High Very High
Non-small-cell Lung Cancer 22 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Bulgaria, MSF cases started to sharply decrease at the beginning of the 1960s and completely disappeared in the 1970s.
Negative_regulation (decrease) of MSF associated with boutonneuse fever
1) Confidence 0.35 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2603122 Disease Relevance 1.21 Pain Relevance 0
Immunoblot analysis of cell culture supernatants showed significantly reduced fibronectin and collagen 1 levels after WIN treatment (supernatants of PSC grown to 100% confluency before initiation of treatment; Figure 7B).
Negative_regulation (reduced) of fibronectin associated with primary sclerosing cholangitis
2) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.41 Pain Relevance 0.14
Activation of cannabinoid receptors, however, induced de-activation of PSC and dose-dependently inhibited growth and decreased IL-6 and MCP-1 secretion as well as fibronectin, collagen1 and alphaSMA levels.
Negative_regulation (decreased) of fibronectin in PSC associated with cannabinoid receptor and primary sclerosing cholangitis
3) Confidence 0.14 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2253501 Disease Relevance 1.21 Pain Relevance 1.03
Mitchell et al[5] studied 112 patients in the first randomization for the effect of G-CSF in FN.
Negative_regulation (effect) of FN associated with neutropenia
4) Confidence 0.12 Published 2005 Journal BMC Med Res Methodol Section Body Doc Link PMC1145185 Disease Relevance 0.46 Pain Relevance 0
With ATRA treatment, leiomyoma cells demonstrated a down-regulation of fibronectin gene to levels comparable to myometrial expression patterns.
Negative_regulation (regulation) of fibronectin gene associated with uterine fibroids
5) Confidence 0.12 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.76 Pain Relevance 0
A number of economic analyses have indicated that the costs of G-CSFs can be at least partially offset by reduction of FN and its associated costs [106–108].
Negative_regulation (reduction) of FN associated with neutropenia
6) Confidence 0.10 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.62 Pain Relevance 0
ligands were shown to inhibit fibronectin
Negative_regulation (inhibit) of fibronectin
7) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 1.12 Pain Relevance 0.04
Moreover, corneas with keratoconus are characterized by upregulation of various enzymes related to remodeling of the ECM and downregulation of genes encoding collagen type IV, laminin, and fibronectin; these downregulated genes encode for the molecules responsible for cell attachment in various basement membranes throughout the body [9-11].
Negative_regulation (downregulation) of fibronectin in body associated with corneal disease
8) Confidence 0.08 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2843708 Disease Relevance 0.93 Pain Relevance 0.12
Our results eliminate a role for a number of potential opsonins, including complement, pentraxin-3, and fibronectin.
Negative_regulation (number) of fibronectin
9) Confidence 0.08 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597001 Disease Relevance 1.02 Pain Relevance 0.24
A meta-analysis of five studies in a total of 617 patients treated for breast cancer or lymphoma showed that a single dose of pegfilgrastim was significantly more effective than 10–14 days of filgrastim in reducing FN (RR 0.64, 95% CI 0.43–0.97) [75].
Negative_regulation (reducing) of FN associated with neutropenia, lymphatic system cancer and breast cancer
10) Confidence 0.07 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.71 Pain Relevance 0
For instance, Kuderer et al. found that FN was reduced by 46% (22.4% vs. 39.5%: RR 0.54, 95% CI 0.43–0.67; p?
Negative_regulation (reduced) of FN associated with neutropenia
11) Confidence 0.07 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.55 Pain Relevance 0
These findings highlight the need to implement official guidelines for preventing FN.
Negative_regulation (preventing) of FN associated with neutropenia
12) Confidence 0.07 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.63 Pain Relevance 0
It is thought that GM-CSF may be less effective than G-CSF in reducing FN and fever [72], and its use has been discontinued in Europe.
Negative_regulation (reducing) of FN associated with neutropenia and fever
13) Confidence 0.07 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.68 Pain Relevance 0
Nevertheless, all three meta-analyses confirmed a substantial FN risk reduction in patients receiving G-CSF/GM-CSF support [69–71].
Negative_regulation (reduction) of FN associated with neutropenia
14) Confidence 0.06 Published 2010 Journal Support Care Cancer Section Body Doc Link PMC2846279 Disease Relevance 0.56 Pain Relevance 0
However, it is important to note that the gene expression analysis was performed only on live, adherent cells, and genes involved in vascular channel formation including fibronectin, collagen, and laminin were downregulated with celecoxib treatment.
Negative_regulation (downregulated) of fibronectin
15) Confidence 0.06 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.43 Pain Relevance 0.11
A series of genes that could generate relevant biologic molecules to form vascular channels were observed to be downregulated with celecoxib treatment, including fibronectin, collagen, and laminin.
Negative_regulation (downregulated) of fibronectin
16) Confidence 0.06 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.26 Pain Relevance 0.09
They bind to a number of extracellular matrix components including fibronectin, laminin, collagen, vitronectin, fibrinogen and thrombospondin.
Negative_regulation (number) of fibronectin in extracellular matrix
17) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1764757 Disease Relevance 0.17 Pain Relevance 0
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Negative_regulation (levels) of Fibronectin
18) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0
Our survey shows that Italian oncologists are particularly oriented towards the use of G-CSF in clinical practice to maintain the CT dose intensity, and are sensitive to the prevention and treatment of not only FN, but also AN.
Negative_regulation (prevention) of FN associated with neutropenia
19) Confidence 0.04 Published 2005 Journal Oncol. Rep. Section Abstract Doc Link 16273232 Disease Relevance 0.92 Pain Relevance 0.07
3: Advanced fibrosis; F4: Cirrhosis; HA: Hyaluronic acid; HAART: Highly active antiretroviral therapy; HCV: Hepatitis C virus; HIV: Human immunodeficiency virus; NPV: Negative predictive value; PPV: Positive predictive value; SE: Sensitivity; SP: Specificity; LR: Likelihood ratio; DOR: Diagnostic odds ratio; TP: True positive cases (correct diagnosis); TN: True negative cases (correct diagnosis); FP: False positive cases (over-diagnosis); FN: False negative cases (missed cases).


Negative_regulation (cases) of FN associated with fibrosis, cirrhosis, acquired immune deficiency syndrome or hiv infection and hepatitis c virus infection
20) Confidence 0.02 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2936897 Disease Relevance 1.25 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox