INT13139

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 17.49
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 6
lymphocytes 4
spinal cord 2
macrophages 1
liver 1
Cd4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 8 99.84 Very High Very High Very High
peptic ulcer disease 2 99.24 Very High Very High Very High
Pain 45 98.84 Very High Very High Very High
Spinal cord 31 95.92 Very High Very High Very High
Inflammation 71 95.68 Very High Very High Very High
qutenza 10 94.64 High High
Serotonin 5 93.68 High High
cytokine 104 93.04 High High
cINOD 3 91.52 High High
Analgesic 17 88.00 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 163 99.90 Very High Very High Very High
Skin Cancer 130 99.90 Very High Very High Very High
Hypergammaglobulinemia 1 99.70 Very High Very High Very High
Viremia 3 99.42 Very High Very High Very High
Cancer 249 99.32 Very High Very High Very High
Disease 18 99.24 Very High Very High Very High
Anaemia 2 99.22 Very High Very High Very High
Malignant Neoplastic Disease 30 99.12 Very High Very High Very High
Ulcers 11 99.08 Very High Very High Very High
Leukopenia 2 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We explain the decreasing CD4+/CD8+ ratio as predominantly due to a decrease of CD4+ T cells as the tumor progresses.
Negative_regulation (decrease) of CD4 in T cells associated with cancer
1) Confidence 0.47 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.88 Pain Relevance 0.03
Lower Helicobacter pylori infection and peptic ulcer disease prevalence in patients with AIDS and suppressed CD4 counts.
Negative_regulation (suppressed) of CD4 associated with peptic ulcer disease, acquired immune deficiency syndrome or hiv infection, ulcers, disease and infection
2) Confidence 0.42 Published 1996 Journal Am. J. Gastroenterol. Section Title Doc Link 8792698 Disease Relevance 0.79 Pain Relevance 0.19
Laboratory abnormalities included a slight elevation of liver enzymes, impairment of liver function tests, leukocytopenia, anemia, hypergammaglobulinemia, and markedly depressed CD4(+)-cell counts.
Negative_regulation (depressed) of CD4 in liver associated with hypergammaglobulinemia, anaemia, leukopenia and congenital anomalies
3) Confidence 0.42 Published 1991 Journal Klin. Wochenschr. Section Abstract Doc Link 1662324 Disease Relevance 1.58 Pain Relevance 0.08
These results indicate that immune blockade of the CD4/CD45 lymphocytic receptors enhanced transgene stability in adult animals with normal or injured spinal cords and that persistent transgene expression in the spinal cord does not interfere with normal neural function.
Negative_regulation (blockade) of CD4 in spinal cord associated with spinal cord
4) Confidence 0.41 Published 1998 Journal Gene Ther. Section Abstract Doc Link 10023440 Disease Relevance 0.23 Pain Relevance 0.13
These results indicate that immune blockade of the CD4/CD45 lymphocytic receptors enhanced transgene stability in adult animals with normal or injured spinal cords and that persistent transgene expression in the spinal cord does not interfere with normal neural function.
Negative_regulation (blockade) of CD4 in spinal cord associated with spinal cord
5) Confidence 0.40 Published 1998 Journal Gene Ther. Section Abstract Doc Link 10023440 Disease Relevance 0.23 Pain Relevance 0.13
A novel immunosuppressive regimen aimed at blocking CD4/CD45 lymphocytic receptors was tested for improving transgene persistence.
Negative_regulation (blocking) of CD4
6) Confidence 0.40 Published 1998 Journal Gene Ther. Section Abstract Doc Link 10023440 Disease Relevance 0.17 Pain Relevance 0.08
The adverse effect of deferring treatment increased with decreasing CD4 cell count threshold.
Negative_regulation (decreasing) of CD4
7) Confidence 0.39 Published 2009 Journal Lancet Section Abstract Doc Link PMC2670965 Disease Relevance 1.07 Pain Relevance 0
Among the infiltrating lymphocytes, CD4+ cells dominated, but during the chronic process there was an increase of CD8+ cells, resulting in a reduced CD4/CD8 ratio.
Negative_regulation (reduced) of CD4 in lymphocytes
8) Confidence 0.39 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11508663 Disease Relevance 0.45 Pain Relevance 0.45
As shown by immunofluorescence and FACS analysis, profound depletion of double negative (DN), double positive (DP), and single positive (SP) CD4(+) cells was already evident at day 7 after treatment and persisted until day 28.
Negative_regulation (depletion) of CD4
9) Confidence 0.39 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10683513 Disease Relevance 0.19 Pain Relevance 0.65
The ratio CD4+/CD8+ was significantly lowered.
Negative_regulation (lowered) of CD4
10) Confidence 0.38 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.17 Pain Relevance 1.04
The present study confirms the decrease in the CD4+/CD8+ ratio with increasing tumor burden.
Negative_regulation (decrease) of CD4 associated with cancer
11) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.74 Pain Relevance 0.04
This relationship appeared to result mainly from a decrease in CD4+ T cells and an increase in CD8+ T cells, especially in group B, as the tumor progressed.
Negative_regulation (decrease) of CD4 in T cells associated with cancer
12) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.77 Pain Relevance 0.04
SD rats with SCCs had decreased CD4+/CD8+ ratios, which were associated with a greater tumor load.
Negative_regulation (decreased) of CD4 associated with cancer and skin cancer
13) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.83 Pain Relevance 0.21
We explain the decreasing CD4+/CD8+ ratio as predominantly due to a decrease of CD4+ T cells as the tumor progresses.
Negative_regulation (decreasing) of CD4 in T cells associated with cancer
14) Confidence 0.34 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1821034 Disease Relevance 0.88 Pain Relevance 0.03
Serum immunoglobulin A, G and M levels were elevated and CD4 positive T cell numbers were low.
Negative_regulation (numbers) of CD4 in T cell
15) Confidence 0.31 Published 1999 Journal J Paediatr Child Health Section Abstract Doc Link 10457303 Disease Relevance 1.13 Pain Relevance 0.20
The serum HIV-1 antibody was positive with a marked loss of CD4 lymphocytes (31/cu mm).
Negative_regulation (loss) of CD4 in lymphocytes associated with acquired immune deficiency syndrome or hiv infection
16) Confidence 0.25 Published 1998 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9868311 Disease Relevance 1.91 Pain Relevance 0.21
When patients were categorised on their NK cell results, there were significant differences in the two groups with raised or low NK cells compared to the "Not PVFS" group: the CD8 cells were increased (p less than 0.001, p less than 0.02) and the CD4/CD8 ratio was reduced (p less than 0.05) but the CD4 cells were normal.
Negative_regulation (reduced) of CD4 in NK cells associated with syndrome
17) Confidence 0.20 Published 1991 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 1815333 Disease Relevance 0.75 Pain Relevance 0.09
In these animals, a concomitant reduction in numbers of macrophages/microglia and CD4 and CD8 lymphocytes was observed.
Negative_regulation (reduction) of CD4 in macrophages
18) Confidence 0.18 Published 1998 Journal Gene Ther. Section Abstract Doc Link 10023440 Disease Relevance 0.23 Pain Relevance 0.14
Postoperative immune function was assessed by measuring the white blood cell (WBC) count, the CD4+ and CD8+ lymphocytes, the CD4+/CD8+/ratio, and the HLA-DR expression of CD14+ monocytes.
Negative_regulation (measuring) of CD4 in monocytes
19) Confidence 0.13 Published 2001 Journal Surg Endosc Section Body Doc Link 11591950 Disease Relevance 0.09 Pain Relevance 0
The mean values for white blood-cell count, absolute lymphocyte count, proportion and absolute CD4, and CD4/CD8 ratio were decreased significantly in the HIV-seropositive group compared with the HIV-seronegative group.
Negative_regulation (decreased) of CD4 in lymphocyte associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.13 Published 1989 Journal AIDS Section Abstract Doc Link 2500957 Disease Relevance 0.97 Pain Relevance 0.19

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