INT131393

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.93
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 20 100.00 Very High Very High Very High
Inflammation 6 99.04 Very High Very High Very High
Gabapentin 54 98.36 Very High Very High Very High
allodynia 14 96.60 Very High Very High Very High
intrathecal 23 94.72 High High
dexamethasone 1 90.16 High High
cINOD 1 89.56 High High
antagonist 7 82.68 Quite High
Inflammatory mediators 1 68.32 Quite High
Inflammatory response 1 66.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.04 Very High Very High Very High
Injury 6 98.60 Very High Very High Very High
Neuropathic Pain 21 96.60 Very High Very High Very High
Nervous System Injury 3 49.48 Quite Low
Sleep Disorders 7 43.20 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
Nociception 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Ganglion Cysts 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We propose, based on the data presented, that the action of LPS to induce UGT1A6 isoform up-regulation may be mediated by pro-inflammatory mediator accumulation, and AP-1 binding activity increase.
Positive_regulation (induce) of Positive_regulation (up-regulation) of UGT1A6 associated with inflammation
1) Confidence 0.50 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.52 Pain Relevance 0.35
Thus, these results suggest that activation of adenosine A1 receptors are required for the synergistic interaction between gabapentin and R-PIA in reducing mechanical allodynia.



Positive_regulation (required) of Positive_regulation (activation) of A1 associated with adenocard, allodynia and gabapentin
2) Confidence 0.14 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.41 Pain Relevance 1.02

General Comments

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