INT131395

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.86
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
jejunum 2
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 3 99.08 Very High Very High Very High
dexamethasone 3 98.08 Very High Very High Very High
Inflammatory mediators 5 87.60 High High
Inflammatory response 7 85.64 High High
Inflammation 101 82.68 Quite High
Paracetamol 3 53.68 Quite High
cytokine 14 27.36 Quite Low
agonist 1 25.00 Low Low
antidepressant 4 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Periodontitis 60 99.98 Very High Very High Very High
INFLAMMATION 110 98.88 Very High Very High Very High
Periodontal Disease 18 47.84 Quite Low
Adhesions 12 36.60 Quite Low
Mouth Disease 2 23.28 Low Low
Diabetes Mellitus 16 5.00 Very Low Very Low Very Low
Alveolar Bone Loss 14 5.00 Very Low Very Low Very Low
Apoptosis 13 5.00 Very Low Very Low Very Low
Infection 10 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this endotoxin-induced increase in UGT1A6 expression level was blocked by actinomycin D and cycloheximide, indicating the requirement for RNA and protein synthesis.
Positive_regulation (increase) of Gene_expression (expression) of UGT1A6
1) Confidence 0.69 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.49 Pain Relevance 0.36
The UGT1A6 expression enhancement could be prevented by anti-inflammatory drugs (dexamethasone and NS398) or nitric oxide synthase inhibitors (L-NAME and L-NMMA).
Positive_regulation (enhancement) of Gene_expression (expression) of UGT1A6 associated with inflammation, cinod and dexamethasone
2) Confidence 0.50 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.48 Pain Relevance 0.38
Moreover, this endotoxin-induced increase in UGT1A6 expression level was blocked by actinomycin D and cycloheximide, indicating the requirement for RNA and protein synthesis.
Positive_regulation (increase) of Gene_expression (expression) of UGT1A6
3) Confidence 0.50 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.49 Pain Relevance 0.36
Messenger RNA and protein levels of UGT1A1 and UGT1A6 in the liver but not the jejunum were increased in male rats fed the HF1 diet.
Positive_regulation (increased) of Gene_expression (levels) of UGT1A6 in jejunum
4) Confidence 0.40 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.11
In contrast Hypericum treatment prevented the periodontitis-mediated iNOS expression (Figure 6a, a1).
Positive_regulation (mediated) of Gene_expression (expression) of a1 associated with periodontitis
5) Confidence 0.04 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.22 Pain Relevance 0.03
In contrast Hypericum treatment prevented the periodontitis-mediated Bax expression (Figure 7a, a1).
Positive_regulation (mediated) of Gene_expression (expression) of a1 associated with periodontitis
6) Confidence 0.04 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.17 Pain Relevance 0
However increasing A1 concentration to 25 ?
Positive_regulation (increasing) of Gene_expression (concentration) of A1
7) Confidence 0.03 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox