INT1314

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Context Info
Confidence 0.16
First Reported 1977
Last Reported 1989
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.14
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Gnrhr) cell-cell signaling (Pomc) cytoplasm (Pomc)
extracellular space (Pomc) generation of precursor metabolites and energy (Pomc) signal transduction (Pomc)
Anatomy Link Frequency
brain 2
central nervous system 2
Pomc (Rattus norvegicus)
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
narcan 7 98.96 Very High Very High Very High
Clonidine 11 98.76 Very High Very High Very High
monoamine 1 98.64 Very High Very High Very High
antagonist 3 98.60 Very High Very High Very High
opiate 2 98.16 Very High Very High Very High
Central nervous system 1 97.68 Very High Very High Very High
agonist 1 97.20 Very High Very High Very High
Opioid 5 78.52 Quite High
Morphine 1 77.40 Quite High
Disease Link Frequency Relevance Heat
Body Weight 2 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of synthetic enkephalin analog (KF 33-824) and beta-endorphin on growth hormone (GH) secretion and their interaction with brain monoamines were investigated in unanesthetized male rats.
beta-endorphin Spec (investigated) Regulation (effects) of Localization (secretion) of growth hormone in brain associated with enkephalin and monoamine
1) Confidence 0.16 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6117022 Disease Relevance 0 Pain Relevance 0.32
The absence of in vitro effect of MS and beta-endorphin on prolactin and growth hormone secretion by cultured rat pituitary cells suggest that they have a central nervous system site of action.
beta-endorphin Regulation (effect) of Localization (secretion) of growth hormone in central nervous system associated with central nervous system
2) Confidence 0.12 Published 1977 Journal Endocrinology Section Abstract Doc Link 187406 Disease Relevance 0 Pain Relevance 0.49
The role of beta-endorphin in the stimulation of growth hormone secretion elicited by administration of clonidine (Clon), an alpha2-adrenergic agonist, was investigated in awake, freely moving male rats.
beta-endorphin Spec (investigated) Regulation (role) of Localization (secretion) of growth hormone associated with agonist and clonidine
3) Confidence 0.06 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2572990 Disease Relevance 0.14 Pain Relevance 0.64

General Comments

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