INT131408

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.70
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Bdkrb1) plasma membrane (Bdkrb1) signal transducer activity (Bdkrb1)
Bdkrb1 (Mus musculus)
Pain Link Frequency Relevance Heat
B1 receptor 2 100.00 Very High Very High Very High
Cancer pain 7 99.30 Very High Very High Very High
antagonist 3 97.28 Very High Very High Very High
Pain 3 91.28 High High
bradykinin 3 81.56 Quite High
IPN 1 80.52 Quite High
Analgesic 1 75.00 Quite High
Breakthrough pain 1 71.56 Quite High
Lasting pain 1 63.40 Quite High
Disease Link Frequency Relevance Heat
Bone Cancer 8 99.48 Very High Very High Very High
Pain 3 91.28 High High
Sarcoma 1 86.92 High High
Inflammatory Pain 1 80.52 Quite High
Injury 1 77.48 Quite High
Cancer 5 73.72 Quite High
Syndrome 1 63.80 Quite High
Disease 1 58.36 Quite High
Cancer Pain 1 55.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With a mouse model of bone cancer pain we demonstrate that pharmacologic blockade of the bradykinin B1 receptor is effective in reducing bone cancer pain-related behaviors, suggesting that B1 antagonists might be useful in attenuating bone cancer pain in humans.
Positive_regulation (effective) of Negative_regulation (blockade) of bradykinin B1 receptor associated with cancer pain, antagonist, b1 receptor and bone cancer
1) Confidence 0.49 Published 2005 Journal J Pain Section Abstract Doc Link 16275602 Disease Relevance 1.70 Pain Relevance 1.32

General Comments

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