INT131413

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 35
Total Number 44
Disease Relevance 17.50
Pain Relevance 36.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NAV1) cytoplasm (NAV1)
Anatomy Link Frequency
neuronal 6
nodes 6
Caov-3 6
Neuron 4
nerve 4
NAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
sodium channel 1360 100.00 Very High Very High Very High
Nav1.7 1220 100.00 Very High Very High Very High
nav1.8 96 100.00 Very High Very High Very High
Nav1.1 47 100.00 Very High Very High Very High
nav1.3 32 100.00 Very High Very High Very High
Nav1.2 19 100.00 Very High Very High Very High
Nav1.6 15 100.00 Very High Very High Very High
addiction 66 99.92 Very High Very High Very High
Congenital analgesia 7 99.92 Very High Very High Very High
Pain 1244 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ovarian Cancer 21 100.00 Very High Very High Very High
Congenital Pain Insensitivity 4 99.92 Very High Very High Very High
Pulpitis 106 99.84 Very High Very High Very High
Neuroblastoma 29 99.76 Very High Very High Very High
Ganglion Cysts 103 99.60 Very High Very High Very High
Reprotox - General 1 61 99.60 Very High Very High Very High
Facial Pain 33 99.56 Very High Very High Very High
INFLAMMATION 191 99.40 Very High Very High Very High
Erythermalgia 109 99.16 Very High Very High Very High
Pain 796 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our observations suggest that the upregulated expression of Nav1.5 in astrocytes may provide a compensatory mechanism, which supports sodium/potassium pump-dependent ionic homoeostasis in areas of central nervous system injury.
Positive_regulation (upregulated) of Gene_expression (expression) of Nav1 in central nervous system associated with nervous system injury and central nervous system
1) Confidence 0.70 Published 2010 Journal Brain Section Abstract Doc Link 20147455 Disease Relevance 0.60 Pain Relevance 0.84
Our results have shown increased expression of the Nav1.3 sodium channel in the spinal cord and thalamus.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in thalamus associated with nav1.3, sodium channel, thalamus and spinal cord
2) Confidence 0.70 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17618978 Disease Relevance 0.75 Pain Relevance 1.21
The increased expression of Nav1.7 within axon bundles of painful samples and the decreased effectiveness of lidocaine on TTX-sensitive NaCh isoforms, both suggest the possible involvement of Nav1.7 in local anesthesia failures.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 associated with tetrodotoxin, pain, anesthesia, sodium channel, lidocaine and nav1.7
3) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.30 Pain Relevance 2.40
Also unknown is the contribution of increased Nav1.7 expression at typical and atypical nodal sites to nerve activity and the pain experience.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in nerve associated with pain and nav1.7
4) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.70 Pain Relevance 1.00
The physiological implications related to the increased expression of Nav1.7 within the painful human dental pulp are unknown but most likely relate to increased neuronal excitability.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in neuronal associated with pain, neuronal excitability and nav1.7
5) Confidence 0.69 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.68 Pain Relevance 0.92
TsA201 cells transfected with the human Nav1.6 cDNA alone exhibited significant persistent sodium current (Ina-p).
Positive_regulation (transfected) of Gene_expression (transfected) of Nav1 associated with nav1.6
6) Confidence 0.50 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775201 Disease Relevance 0 Pain Relevance 0.46
This evaluation further allowed the characterization of Nav1.7 at some caspr-identified atypical sites that were classified as split nodes where two distinct Nav1.7 accumulations were separated by a gap in the Nav1.7 staining within the same fiber and with each Nav1.7 accumulation being flanked on only one side by caspr.


Positive_regulation (accumulation) of Gene_expression (staining) of Nav1 in nodes associated with nav1.7
7) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.93
To facilitate the identification of NaV1.8-specific inhibitors, we stably expressed the human NaV1.8 channel together with the auxiliary human beta1 subunit (NaV beta1) in human embryonic kidney 293 cells.
Positive_regulation (expressed) of Gene_expression (expressed) of NaV beta1 in embryonic kidney associated with sodium channel
8) Confidence 0.47 Published 2006 Journal Assay Drug Dev Technol Section Abstract Doc Link 16506887 Disease Relevance 0.41 Pain Relevance 1.07
Our study has helped to localise the increased expression of Nav1.7 to the subodontoblastic plexus within painful pulp.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 associated with pain and nav1.7
9) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.05 Pain Relevance 1.18
One recent study investigated pain within the orofacial pain region and showed an increase in Nav1.7 expression in pulpitis [22], while another study showed a decrease in Nav1.7 in the neuropathic orofacial pain condition trigeminal neuralgia (TN) [26].
Positive_regulation (increase) of Gene_expression (expression) of Nav1 associated with pain, pulpitis, face pain, neuropathic pain and nav1.7
10) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 1.80 Pain Relevance 2.22
The inflammatory mediators within pulp may up-regulate the expression of Nav1.7, as may micro-organisms within the oral cavity by causing inflammation.
Positive_regulation (regulate) of Gene_expression (expression) of Nav1 in oral cavity associated with inflammatory mediators, inflammation and nav1.7
11) Confidence 0.47 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2890014 Disease Relevance 0.90 Pain Relevance 1.15
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
12) Confidence 0.47 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (higher) of Spec (analyzed) Gene_expression (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
13) Confidence 0.47 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.66 Pain Relevance 0.65
Relative mRNA expression levels of Nav1.1, Nav1.3, Nav1.4 and Nav1.5, analyzed by RT-PCR, were significantly higher in ovarian cancers cells compared with normal ovarian tissues; relative mRNA expression levels of Nav1.2, Nav1.4, Nav1.5 and Nav1.7 were significantly increased in highly metastatic ovarian cancer cells (Caov-3 and SKOV-3) compared with low-metastatic ovarian cancer cells (Anglne).
Positive_regulation (higher) of Gene_expression (expression) of Nav1 in Caov-3 associated with nav1.3, nav1.1, ovarian cancer, nav1.2 and nav1.7
14) Confidence 0.47 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20372843 Disease Relevance 0.68 Pain Relevance 0.66
Here, we use this model system to evaluate the expression of Nav1.7 within normal and painful human pulpal specimens with the use of quantitative methods and demonstrate increased axonal expression of Nav1.7 within axon bundles and at typical and atypical nodal sites that showed alterations in myelin staining relationships within painful samples.


Positive_regulation (increased) of Gene_expression (expression) of Nav1 associated with pain and nav1.7
15) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.55 Pain Relevance 1.28
Nav1.7 expression is increased in painful human dental pulp

Background

Positive_regulation (increased) of Gene_expression (expression) of Nav1 in dental pulp associated with pain and nav1.7
16) Confidence 0.46 Published 2008 Journal Mol Pain Section Title Doc Link PMC2377237 Disease Relevance 0.27 Pain Relevance 1.25
Quantitative methods showed an increased overall nerve fiber expression of Nav1.7 within axonal bundles but with no difference in expression within fibers located in the pulp horn, while single fiber analysis of caspr-identified nodal sites showed an increased expression of the isoform at typical and atypical nodal sites.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in horn associated with nav1.7
17) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0.21 Pain Relevance 0.71
Our findings identify increased axonal expression of Nav1.7 within the painful human dental pulp that includes an increased expression at intact and remodeling/demyelinating nodal sites.
Positive_regulation (increased) of Gene_expression (expression) of Nav1 in dental pulp associated with pain, demyelinating disease and nav1.7
18) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 1.45 Pain Relevance 1.56
This analysis showed a dramatic increase in the percentage of nodal sites with Nav1.7 expression in painful samples within coronal and upper radicular regions (Figs. 4E,F).
Positive_regulation (increase) of Gene_expression (expression) of Nav1 in upper associated with pain and nav1.7
19) Confidence 0.46 Published 2008 Journal Mol Pain Section Body Doc Link PMC2377237 Disease Relevance 0 Pain Relevance 0.81
In addition, BPBTS was two orders of magnitude more potent than the clinically used anticonvulsant and antiarrhythmic Nav1 blockers, inhibiting the inactivated state of Nav1.8, Nav1.7, Nav1.5, and Nav1.2, with Ki values of 0.09, 0.15, 0.08, and 0.14 ?
Positive_regulation (inactivated) of Gene_expression (state) of Nav1 associated with nav1.2, nav1.8, anticonvulsant and nav1.7
20) Confidence 0.45 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2346569 Disease Relevance 0 Pain Relevance 0.54

General Comments

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