INT131434

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPKAPK2) nucleoplasm (MAPKAPK2) small molecule metabolic process (MAPKAPK2)
nucleus (MAPKAPK2) response to stress (MAPKAPK2) cytoplasm (MAPKAPK2)
MAPKAPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 95.52 Very High Very High Very High
Inflammatory response 1 92.12 High High
cINOD 1 58.64 Quite High
anesthesia 1 47.92 Quite Low
Spinal cord 6 27.84 Quite Low
Inflammation 1 25.00 Low Low
Somatosensory cortex 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Pyramidal cell 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 99.60 Very High Very High Very High
INFLAMMATION 2 91.76 High High
Aging 1 88.80 High High
Amputation 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low
Infarction 1 5.00 Very Low Very Low Very Low
Paresis 1 5.00 Very Low Very Low Very Low
Stroke 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mk1 and Mk2 were also implanted during 4 weeks with an osmotic pump, but delivering a control antibody.
Mk2 Binding (implanted) of
1) Confidence 0.17 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1224856 Disease Relevance 0 Pain Relevance 0
We have shown that MK2 directly phosphorylates HSF1 and inhibits activity by decreasing its ability to bind the heat shock elements (HSE) found in the promoters of target genes encoding the HSP molecular chaperones and cytokine genes.
MK2 Binding (bind) of associated with shock and cytokine
2) Confidence 0.11 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16278218 Disease Relevance 0.42 Pain Relevance 0.20

General Comments

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