INT13145

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Context Info
Confidence 0.70
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 60
Total Number 63
Disease Relevance 16.32
Pain Relevance 23.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)
Anatomy Link Frequency
neurons 5
hippocampus 4
spike 3
pyramidal neurons 3
dentate gyrus 2
Car1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 678 100.00 Very High Very High Very High
Hippocampus 412 100.00 Very High Very High Very High
long-term potentiation 301 100.00 Very High Very High Very High
ASIC 54 100.00 Very High Very High Very High
Glutamate 22 100.00 Very High Very High Very High
Somatostatin 13 100.00 Very High Very High Very High
opioid receptor 11 100.00 Very High Very High Very High
Pyramidal cell 748 99.96 Very High Very High Very High
Morphine 33 99.80 Very High Very High Very High
amygdala 43 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 464 100.00 Very High Very High Very High
Death 101 100.00 Very High Very High Very High
Stress 87 100.00 Very High Very High Very High
Cv Unclassified Under Development 198 99.98 Very High Very High Very High
Body Weight 6 99.96 Very High Very High Very High
Hypoxia 42 99.84 Very High Very High Very High
Pain 204 99.70 Very High Very High Very High
Convulsion 48 99.70 Very High Very High Very High
Nociception 151 99.64 Very High Very High Very High
INFLAMMATION 21 99.58 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these data indicate that the early positive-to-negative phase of the waveform in CA1 evoked by the AB test stimulus reflects events in the DG and not direct activation of CA1 by entorhinal cortical afferents.
Neg (not) Positive_regulation (activation) of CA1
1) Confidence 0.70 Published 1994 Journal Brain Res. Section Abstract Doc Link 8012831 Disease Relevance 0.13 Pain Relevance 0.08
These data suggest that morphine dependence in rats does not interfere with the induction and maintenance of hippocampal CA1 LTP.
Positive_regulation (induction) of CA1 associated with addiction, long-term potentiation and morphine
2) Confidence 0.67 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560114 Disease Relevance 0.19 Pain Relevance 0.99
Thus, it may be suggested that in amygdala kindling, activation of the hippocampal CA1 region has a role in seizure acquisition and seizure severity so that inhibition of this region results in decreasing of seizure severity and retards amygdala kindling rate.
Positive_regulation (activation) of CA1 in amygdala associated with convulsion and amygdala
3) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12414105 Disease Relevance 0.59 Pain Relevance 0.85
The probability of seizure generation in CA1 was increased with increasing duration of hypoxia and was greatly reduced by lowering the bath temperature a few degrees. 3.
Positive_regulation (increased) of CA1 associated with convulsion and hypoxia
4) Confidence 0.56 Published 1990 Journal J. Neurophysiol. Section Abstract Doc Link 2158521 Disease Relevance 1.44 Pain Relevance 0.21
In situ hybridization analysis, one day after the last kindling stimulation, showed significant elevations of SS mRNA in CA1, CA2 and dentate gyrus of hippocampus and of PE mRNA in olfactory cortex that were specific to kindling.
Positive_regulation (elevations) of CA1 in olfactory cortex associated with somatostatin and hippocampus
5) Confidence 0.49 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684628 Disease Relevance 0.09 Pain Relevance 0.44
These results suggest a role of CA3 pyramidal neurons in the generation of CA1 theta via the activation of NMDA receptors of CA1 pyramidal neurons.
Positive_regulation (generation) of CA1 in pyramidal neurons associated with nmda receptor and pyramidal cell
6) Confidence 0.49 Published 2002 Journal Hippocampus Section Abstract Doc Link 12201628 Disease Relevance 0 Pain Relevance 0.48
In the present study, the net effect of activation of CA1 ?
Positive_regulation (activation) of CA1
7) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.32
Therefore, in the presence of PNU-120596, the net effect on the hippocampal output of activation of CA1 ?
Positive_regulation (activation) of CA1
8) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.28
The formalin injection-induced selective activation of CA1 complex spike cells against a background of widespread pyramidal cell suppression might produce a "signal to noise" contributory to nociceptive processing in limbic structures.
Positive_regulation (activation) of CA1 in spike associated with nociception and pyramidal cell
9) Confidence 0.47 Published 1997 Journal Neuroscience Section Abstract Doc Link 9070747 Disease Relevance 0.37 Pain Relevance 0.53
Interestingly, adenosine A1 receptors in the grafted side had significantly increased not only in the CA1 but also in the stratum oriens of the CA3 compared with that in the non-grafted side.
Positive_regulation (increased) of CA1 associated with adenocard
10) Confidence 0.47 Published 1993 Journal Neuroscience Section Abstract Doc Link 8247265 Disease Relevance 0 Pain Relevance 0.37
At this time, kainate and muscarinic cholinergic receptors in grafts had increased up to the near normal level of the CA1 in the hippocampus.
Positive_regulation (increased) of CA1 in hippocampus associated with hippocampus
11) Confidence 0.47 Published 1993 Journal Neuroscience Section Abstract Doc Link 8247265 Disease Relevance 0 Pain Relevance 0.39
G-protein activation in superficial cortical layers and hippocampal CA1-3 region was mainly attributed to Y1 and Y2 receptors, respectively.
Positive_regulation (activation) of CA1
12) Confidence 0.45 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368969 Disease Relevance 0 Pain Relevance 0.23
These data suggest that morphine dependence in rats does not interfere with the induction and maintenance of hippocampal CA1 LTP.
Positive_regulation (maintenance) of CA1 associated with addiction, long-term potentiation and morphine
13) Confidence 0.45 Published 2003 Journal Brain Res. Section Abstract Doc Link 12560114 Disease Relevance 0.19 Pain Relevance 0.99
Muscarinic receptor activity induces an afterdepolarization in a subpopulation of hippocampal CA1 interneurons.
Positive_regulation (subpopulation) of CA1 in interneurons
14) Confidence 0.45 Published 1999 Journal J. Neurosci. Section Title Doc Link 10407011 Disease Relevance 0.09 Pain Relevance 0.23
The effects of BPA on rapid estrogen induction of CA1 PSSD may reflect interference, directly or indirectly, with this putative novel estrogen response pathway.
Positive_regulation (induction) of CA1 PSSD
15) Confidence 0.45 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.04
-E2 both induce an increase in PSSD is consistent with the hypothesis that membrane-associated ERs may mediate rapid estrogen activation of CA1 spine synapse formation (Wade et al. 2001).
Positive_regulation (activation) of CA1 in synapse
16) Confidence 0.45 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.05
The 15 mg/kg dose of morphine resulted in an augmentation of the field potential recorded in CA1 following stimulation of stratum radiatum, as shown by an increase in the size of the primary spike and the appearance of (an) additional population spike(s).
Positive_regulation (augmentation) of CA1 in spike associated with morphine
17) Confidence 0.44 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 7088269 Disease Relevance 0 Pain Relevance 0.45
RESULTS: Morphine dependence increased a PTZ-induced long-term potentiation (LTP) of the population spike in CA1 in vitro.
Positive_regulation (increased) of CA1 in spike
18) Confidence 0.44 Published 2009 Journal Epilepsia Section Body Doc Link 19183220 Disease Relevance 0 Pain Relevance 0
We conclude that brief exposures to CN and hypoxia alter the intrinsic excitability of CA1 neurons by at least two mechanisms: 1) alterations in leakage currents and 2) alterations in the fast Na+ conductance that are maturationally dependent.
Positive_regulation (excitability) of CA1 in neurons associated with hypoxia
19) Confidence 0.43 Published 1991 Journal J. Neurophysiol. Section Abstract Doc Link 1662712 Disease Relevance 0.23 Pain Relevance 0.11
tetanizing the ventral CA1, the early positive wave of EC responses to CA1 test
Positive_regulation (responses) of CA1 in ventral
20) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0

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