INT131457

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 4.88
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FCGR1A) plasma membrane (FCGR1A)
Anatomy Link Frequency
macrophages 1
blood vessels 1
NK cells 1
eosinophil 1
mast cell 1
FCGR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 37 100.00 Very High Very High Very High
agonist 11 99.96 Very High Very High Very High
antagonist 10 99.44 Very High Very High Very High
adenocard 15 94.32 High High
backache 6 77.00 Quite High
palliative 5 72.12 Quite High
midbrain 20 68.72 Quite High
Dopamine 84 68.00 Quite High
Bile 6 67.88 Quite High
Angina 3 52.08 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 13 97.12 Very High Very High Very High
Atherosclerosis 15 96.86 Very High Very High Very High
Apoptosis 18 96.56 Very High Very High Very High
Disease 40 96.24 Very High Very High Very High
Hepatitis C Virus Infection 2 95.84 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 1 95.84 Very High Very High Very High
Hepatitis 2 94.92 High High
Follicular Lymphoma 1 94.68 High High
Fascioliasis 4 92.00 High High
Toxicity 14 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, expression of TGFbetaRII, FGFR3 and IGFRI, but not BMP RII, were observed in the ingrowing blood vessels that characterize part of the disease aetiology.
Gene_expression (expression) of IGFRI in blood vessels associated with disease
1) Confidence 0.75 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.22 Pain Relevance 0.09
This immunohistochemical study has for the first time investigated the expression and localization of four potentially beneficial growth factor receptors (i.e.
Gene_expression (expression) of IGFRI
2) Confidence 0.65 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.36 Pain Relevance 0.26
It is noteworthy that the increased expression of CD64/Fc?
Gene_expression (expression) of CD64
3) Confidence 0.34 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.37 Pain Relevance 0
It is noteworthy that the increased expression of CD64/Fc?
Gene_expression (expression) of CD64
4) Confidence 0.30 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2654967 Disease Relevance 0.37 Pain Relevance 0
In addition, previous focused gene expression array revealed that IGFR1, IGFR2 and CXCR4 were expressed in undifferentiated BG03 hESC [32].
Gene_expression (expressed) of IGFR1
5) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0 Pain Relevance 0.13
EGFR, HGFR and IGFR1 were present in all four cell lines tested.
Gene_expression (present) of IGFR1
6) Confidence 0.19 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2896958 Disease Relevance 0.82 Pain Relevance 0.11
In view of the controversy regarding the mechanism of cholesterol uptake by monocyte-macrophages in atherosclerosis and diabetes [20,21] and the previous lack of in vivo data to help elucidate any role of the Fc receptors in this process, we have prospectively determined IgG-binding receptor expression levels for each Fc?
Gene_expression (expression) of IgG-binding receptor in macrophages associated with diabetes mellitus and atherosclerosis
7) Confidence 0.09 Published 2004 Journal Immun Ageing Section Body Doc Link PMC544957 Disease Relevance 0.88 Pain Relevance 0.08
Additionally, receptor selectivity may vary with relatively small changes in ligand structure: an 8-cycloalkyl substituent on theophylline confers A1 receptor selectivity, whereas a phenylstyryl substituent on the same position in caffeine renders these compounds selective for the A2A receptor.
Gene_expression (selective) of A1 receptor
8) Confidence 0.06 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2897831 Disease Relevance 0 Pain Relevance 0.24
Most zoonotic helminthes induced immune response (Nutman, 2001) characterized by producing of type 2 cytokines, Ig G1, IgG2, IgE antibodies and eosinophil and mast cell activation (Hoffman et al., 2002).
Gene_expression (producing) of Ig G1 in mast cell associated with cytokine
9) Confidence 0.04 Published 2008 Journal J Egypt Soc Parasitol Section Abstract Doc Link 19209761 Disease Relevance 0.68 Pain Relevance 0.05
In this study newly synthesized selective A1 receptor agonists and antagonists were investigated thereby integrating three parameters, insulin release (RIA), 45Ca2+ uptake and 86Rb+ efflux (surrogate for K+ efflux) of INS-1 cells, an insulin secretory cell line.
Spec (investigated) Gene_expression (synthesized) of A1 receptor in secretory cell associated with antagonist and agonist
10) Confidence 0.03 Published 2008 Journal Cell Biochem. Funct. Section Abstract Doc Link 18979526 Disease Relevance 0.10 Pain Relevance 0.45
A polymorphism in Fc gammaR IIIa receptor, Fc gammaR IIIa-158, which is expressed on NK cells and associated with enhanced ADCC, is linked with increased cetuximab activity in HNSCC cells in vitro.45 Clinically, variation in Fc?
Gene_expression (expressed) of Fc gammaR IIIa receptor in NK cells
11) Confidence 0.02 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2921255 Disease Relevance 0.39 Pain Relevance 0
Most zoonotic helminthes induced immune response (Nutman, 2001) characterized by producing of type 2 cytokines, Ig G1, IgG2, IgE antibodies and eosinophil and mast cell activation (Hoffman et al., 2002).
Gene_expression (producing) of Ig G1 in eosinophil associated with cytokine
12) Confidence 0.01 Published 2008 Journal J Egypt Soc Parasitol Section Abstract Doc Link 19209761 Disease Relevance 0.68 Pain Relevance 0.05

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