INT131462

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.97
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NGF, INS) extracellular region (NGF, INS) endosome (NGF)
signal transduction (NGF) small molecule metabolic process (INS) carbohydrate metabolic process (INS)
NGF (Homo sapiens)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 15 100.00 Very High Very High Very High
tolerance 3 96.44 Very High Very High Very High
Congenital analgesia 3 96.24 Very High Very High Very High
Hsan 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 3 96.44 Very High Very High Very High
Pain 3 96.24 Very High Very High Very High
Syndrome 3 94.80 High High
Hereditary Sensory And Autonomic Neuropathies 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CIPA suggests for the first time that the NGF-TrkA pathway may play a role in insulin secretion in response to glucose challenge in humans.
NGF Regulation (role) of Localization (secretion) of insulin associated with nerve growth factor
1) Confidence 0.40 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279365 Disease Relevance 0.33 Pain Relevance 0.41
Additional studies on the clinical significance of NGF-TrkA effects on insulin secretion are required.
NGF Regulation (effects) of Localization (secretion) of insulin associated with nerve growth factor
2) Confidence 0.24 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279365 Disease Relevance 0.31 Pain Relevance 0.39
We hypothesized that CIPA may represent a natural model for impaired NGF effect on insulin secretion in humans.
NGF Regulation (effect) of Localization (secretion) of insulin associated with nerve growth factor
3) Confidence 0.24 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16279365 Disease Relevance 0.34 Pain Relevance 0.41

General Comments

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