INT131472

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.95
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde5a) signal transduction (Pde5a)
Anatomy Link Frequency
neuronal 1
endothelial cells 1
smooth muscle 1
spinal cord 1
neurons 1
Pde5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 23 99.68 Very High Very High Very High
Central nervous system 4 99.04 Very High Very High Very High
Spinal cord 4 98.76 Very High Very High Very High
Hyperalgesia 22 97.64 Very High Very High Very High
Inflammation 4 97.12 Very High Very High Very High
Antinociceptive 14 95.72 Very High Very High Very High
Angina 8 95.60 Very High Very High Very High
fibrosis 20 93.16 High High
substantia gelatinosa 2 92.48 High High
Acute pain 6 88.72 High High
Disease Link Frequency Relevance Heat
Toxicity 4 99.76 Very High Very High Very High
Erectile Dysfunction 273 98.88 Very High Very High Very High
Hyperalgesia 25 97.64 Very High Very High Very High
Natriuresis 9 97.52 Very High Very High Very High
INFLAMMATION 4 97.12 Very High Very High Very High
Nociception 22 97.00 Very High Very High Very High
Cv General 3 Under Development 9 95.60 Very High Very High Very High
Injury 27 93.68 High High
Fibrosis 16 93.16 High High
Hypotension 7 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to evaluate the effect of the PDE-5 inhibitor sildenafil on central or peripheral administration in formalin-induced hyperalgesia in rats.
Regulation (effect) of PDE-5 associated with hyperalgesia
1) Confidence 0.42 Published 2005 Journal Inflammopharmacology Section Abstract Doc Link 16280099 Disease Relevance 0.41 Pain Relevance 0.25
Alternatively, drugs that modulate the NO-cGMP signaling pathway like sildenafil and probably its congeners may be useful especially that sildenafil proved to be cardioprotective in models of cardiac I/R injury.
Regulation (modulate) of NO-cGMP associated with injury
2) Confidence 0.34 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.63 Pain Relevance 0.04
Although the effectiveness of PDE5 inhibitors on such intermediate objective outcomes as penile rigidity through penile plethysmography with the RigiScan device (Dacomed Corporation, Minneapolis, MN, USA) has been studied, measuring the therapeutic effectiveness of tadalafil is more accurately defined through an integration of the patientÂ’s reported treatment response and tolerability with the reported satisfaction of both the patient and his partner (Carson et al 2004b).
Regulation (effectiveness) of PDE5
3) Confidence 0.24 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643112 Disease Relevance 0.84 Pain Relevance 0.03
The cardiac effects of PDE5 inhibitors have received considerable attention because the drugs were originally studied as a treatment for angina pectoris secondary to their action of smooth muscle relaxation.
Regulation (effects) of PDE5 in smooth muscle associated with angina
4) Confidence 0.24 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643112 Disease Relevance 1.19 Pain Relevance 0.31
On the other hand, various phosphodiesterases regulate cGMP catabolism, including PDE-5A, PDE-6, PDE-9A, PDE-10A, and PDE-11A according to their tissue specificity [21-23].
Regulation (regulate) of PDE-5A
5) Confidence 0.20 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.35 Pain Relevance 0.04
Therefore, it is conceivable that the increased cGMP level by inhibition of phosphodiesterase may contribute to the antinociception in the spinal cord.
Spec (may) Regulation (contribute) of cGMP in spinal cord associated with antinociception and spinal cord
6) Confidence 0.19 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610640 Disease Relevance 0.58 Pain Relevance 0.70
The effects of PDE-5 blockade varied as a positive function of ambient Po(2).
Regulation (effects) of PDE-5
7) Confidence 0.19 Published 2009 Journal J. Appl. Physiol. Section Abstract Doc Link 19179645 Disease Relevance 0.76 Pain Relevance 0.05
On the other hand, the activity of phosphodiesterase 5 was detected in smooth muscle cells of vessels.17 Also, cGMP plays important role in the regulation of vascular tone,18 and it has recently been reported that phosphodiesterase 5 is the key enzyme involved in the regulation of the cGMP-associated vascular relaxation.19 Therefore, hemodynamic change due to vasodilating effect of phosphodiesterase 5 inhibitor is expected.
Regulation (regulation) of cGMP in vessels
8) Confidence 0.11 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2799976 Disease Relevance 0.29 Pain Relevance 0.73
Recent studies have reported that a long-term use of PDE5 inhibitor showed effectiveness among patients who complained of erectile dysfunction after the prostatectomy.7, 8 Also, there were animal studies that attempted to show the effects of the PDE5 inhibitors in treating the erectile dysfunction.9 These results proposed the possibility that a recovery of erectile function could be achieved by preventing NOS-induced fibrosis and increasing muscle fibers after the prostatectomy.
Regulation (effects) of PDE5 in muscle fibers associated with fibrosis and erectile dysfunction
9) Confidence 0.05 Published 2010 Journal Int J Impot Res Section Body Doc Link PMC2959156 Disease Relevance 0.75 Pain Relevance 0.12
Our results suggest that cofilin represents a downstream target of NO/cGMP/PKG signal transduction in neurons thus indicating that it is involved in NO-mediated nociception.
Regulation (target) of cGMP in neurons associated with nociception
10) Confidence 0.04 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19896457 Disease Relevance 0.61 Pain Relevance 0.37
Sildenafil, a phosphodiesterase inhibitor, given orally, has been shown to be a potent and selective pulmonary vasodilator.60 Sildenafil works by selectively inhibiting phos-phodiesterase V (PDE V),61 which is responsible for cGMP breakdown in lung tissue.
Regulation (responsible) of PDE V in lung
11) Confidence 0.03 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2697585 Disease Relevance 0.54 Pain Relevance 0.31
To investigate this pathway in large DRG neurons, we examined the effect of a membrane permeable cGMP analogue, 8-Br-cGMP, on neuronal KATP channel activity in cell-attached patch recordings.
Spec (examined) Regulation (effect) of cGMP in neuronal
12) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
Most recently, studies on rat optic nerve found that NO coming from endothelial cells persistently depolarizes axons through cGMP acting on HCN channels (Garthwaite et al., 2006).
Regulation (acting) of cGMP in endothelial cells
13) Confidence 0.01 Published 2010 Journal The European Journal of Neuroscience Section Body Doc Link PMC2955965 Disease Relevance 0 Pain Relevance 0.12

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