INT131488

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 8.49
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MAS1) plasma membrane (MAS1) signal transducer activity (MAS1)
Anatomy Link Frequency
sensory neuron 1
juvenile 1
MAS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 1 98.96 Very High Very High Very High
cytokine 21 96.68 Very High Very High Very High
Inflammation 24 96.28 Very High Very High Very High
Pain 41 96.04 Very High Very High Very High
rheumatoid arthritis 109 95.64 Very High Very High Very High
headache 7 94.44 High High
drug abuse 7 79.76 Quite High
agonist 15 75.00 Quite High
Inflammatory mediators 3 73.84 Quite High
Potency 1 64.76 Quite High
Disease Link Frequency Relevance Heat
Polyostotic Fibrous Dysplasia 177 100.00 Very High Very High Very High
Macrophage Activation Syndrome 39 100.00 Very High Very High Very High
Malignant Neoplastic Disease 22 99.68 Very High Very High Very High
Obstructive Sleep Apnea 163 98.96 Very High Very High Very High
Rheumatic Diseases 7 98.72 Very High Very High Very High
Fibrous Dysplasia Of Bone 252 98.36 Very High Very High Very High
Disease 154 97.40 Very High Very High Very High
INFLAMMATION 24 96.28 Very High Very High Very High
Pain 42 96.04 Very High Very High Very High
Rheumatoid Arthritis 110 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions between the Mas-related receptors MrgD and MrgE alter signalling and trafficking of MrgD.
Mas Binding (Interactions) of
1) Confidence 0.36 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16282220 Disease Relevance 0.07 Pain Relevance 0.03
Human sensory neuron-specific mas-related gene X1 receptors (hMrgX1s) belong to the superfamily of G protein-coupled receptors (GPCRs), bind cleavage products of pro-enkephalin with high affinity, and have been suggested to participate in pain sensation.
mas Binding (bind) of in sensory neuron associated with pain and enkephalin
2) Confidence 0.35 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20424127 Disease Relevance 0.10 Pain Relevance 0.29
While malignancies associated with MAS are distinctly rare occurrences, they warrant mentioning due to their importance.
MAS Binding (associated) of associated with polyostotic fibrous dysplasia
3) Confidence 0.16 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459161 Disease Relevance 1.46 Pain Relevance 0
Malignancies associated with MAS are distinctly rare occurrences.
MAS Binding (associated) of associated with polyostotic fibrous dysplasia
4) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2459161 Disease Relevance 1.20 Pain Relevance 0
Malignant transformation of FD lesions is probably the most common and best described malignancy that occurs in association with MAS [12,16,19].
MAS Binding (association) of associated with fibrous dysplasia of bone, malignant neoplastic disease and polyostotic fibrous dysplasia
5) Confidence 0.12 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459161 Disease Relevance 1.71 Pain Relevance 0
There are no clinically significant cardiovascular effects associated with MAS XR in adults.


MAS XR Neg (no) Binding (associated) of
6) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697545 Disease Relevance 0.64 Pain Relevance 0.13
Mandibular advancement splints (MAS)
MAS Binding (splints) of
7) Confidence 0.02 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671821 Disease Relevance 0.45 Pain Relevance 0.06
However, the cause of the immunologic derangement associated with MAS is unknown.
MAS Binding (associated) of associated with macrophage activation syndrome
8) Confidence 0.02 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 1.15 Pain Relevance 0.31
Although MAS has been increasingly recognized in association with almost any rheumatic disease, it is by far most common in the systemic form of juvenile rheumatoid arthritis (JRA) [1,5-11].
MAS Binding (recognized) of in juvenile associated with macrophage activation syndrome, rheumatoid arthritis and rheumatic diseases
9) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064882 Disease Relevance 1.70 Pain Relevance 0.18

General Comments

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