INT131494

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 7.37
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ADA) aging (ADA) cytoplasm (ADA)
cytosol (ADA) extracellular space (ADA) cell adhesion (ADA)
ADA (Homo sapiens)
Pain Link Frequency Relevance Heat
Adalimumab 844 100.00 Very High Very High Very High
adenocard 201 100.00 Very High Very High Very High
Endep 1 100.00 Very High Very High Very High
antidepressant 9 99.60 Very High Very High Very High
Fibrositis 11 98.84 Very High Very High Very High
alcohol 9 84.56 Quite High
antagonist 26 82.24 Quite High
Central nervous system 27 75.32 Quite High
corticosteroid 80 74.48 Quite High
cytokine 16 65.60 Quite High
Disease Link Frequency Relevance Heat
Disease 412 99.84 Very High Very High Very High
Mycobacterial Infection 301 99.44 Very High Very High Very High
Sleep Disorders 8 98.84 Very High Very High Very High
Tuberculous Peritonitis 25 98.48 Very High Very High Very High
Apoptosis 12 98.24 Very High Very High Very High
Infection 39 98.00 Very High Very High Very High
Meningitis 78 95.76 Very High Very High Very High
Neurological Disease 43 95.52 Very High Very High Very High
Adhesions 4 94.84 High High
Pressure And Volume Under Development 24 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The efficacy of ADA was not affected by the use or non use of immunosuppressive agents in either the open-label cohort or the randomized cohort.
Regulation (efficacy) of ADA associated with adalimumab
1) Confidence 0.52 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0 Pain Relevance 0.33
The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated.
Spec (investigated) Regulation (effect) of ADA associated with adenocard and endep
2) Confidence 0.44 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16283318 Disease Relevance 0.68 Pain Relevance 0.44
It should be noted that, although uncontrolled remission rates at the end of the open-label induction phase were not a primary endpoint in CHARM, which was designed and powered to evaluate the efficacy of ADA for maintenance therapy, the induction-loading dose regimen used (80 mg/40 mg) provided similar response rates (70-point decrease in CDAI of 58%) to both the 80 mg/40 mg and 160 mg/80 mg regimens in CLASSIC I (59% for each regimen).
Regulation (efficacy) of ADA associated with adalimumab
3) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0 Pain Relevance 0.40
The efficacy of ADA was not affected by the use or non use of immunosuppressive agents in either the open-label cohort or the randomized cohort.
Neg (not) Regulation (affected) of ADA associated with adalimumab
4) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0 Pain Relevance 0.33
In addition to neutralizing TNF-alpha, the clinical efficacy of ADA in CD also appears to involve induction of apoptosis (Shen et al 2005, 2006).
Regulation (efficacy) of ADA associated with adalimumab, apoptosis and disease
5) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727899 Disease Relevance 0.62 Pain Relevance 0.39
A cut off value of ADA activity for TBM patients was calculated from the mean plus SD of ADA activity in the non-TBM infectious meningitis group.
Regulation (value) of ADA associated with mycobacterial infection and meningitis
6) Confidence 0.18 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1448186 Disease Relevance 1.25 Pain Relevance 0.08
The cut off value of the ADA activity for the diagnosis of TBM patients was, calculated as 9.25 + 2.14 = 11.39 U/L/min.
Regulation (value) of ADA associated with mycobacterial infection
7) Confidence 0.18 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1448186 Disease Relevance 1.98 Pain Relevance 0.04
In the present study we have calculated an ADA cut-off value of 11.39 U/L/min in CSF for the diagnosis of TBM infection.
Regulation (value) of ADA associated with mycobacterial infection and infection
8) Confidence 0.18 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1448186 Disease Relevance 1.35 Pain Relevance 0
The pertinent literature judges the usefulness of ADA levels in ascitic fluid as a diagnostic test for peritoneal tuberculosis differently.
Regulation (usefulness) of ADA associated with tuberculous peritonitis
9) Confidence 0.12 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2267201 Disease Relevance 1.24 Pain Relevance 0.05
Several potential explanations of the unexpected ineffectiveness of both enteric-coated ATP and adenosine on indomethacin-induced permeability changes in the present study can be put forward.
Regulation (coated) of adenosine associated with adenocard
10) Confidence 0.05 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1913056 Disease Relevance 0.06 Pain Relevance 0.22
Antidepressants have been shown to affect activity of the enzyme adenosine deaminase [28,29], which catalyzes the breakdown of adenosine to inosine.
Regulation (affect) of adenosine associated with adenocard and antidepressant
11) Confidence 0.03 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1913056 Disease Relevance 0.13 Pain Relevance 0.53
To be able to detect at least half of the previously observed effect, that is ~15% reduction in L/R ratio, based on the standard deviation of 0.021 and a correlation between paired measures of 0.60 (i.e. a conservative estimate relative to the correlation of 0.74 observed in our previous study), it was calculated that 31 subjects would be sufficient to detect a significant effect of ATP/adenosine on an indomethacin-induced increase in L/R ratio with a power of 90% and two-tailed alpha of 0.05.
Regulation (effect) of adenosine associated with adenocard
12) Confidence 0.03 Published 2007 Journal BMC Gastroenterol Section Body Doc Link PMC1913056 Disease Relevance 0.06 Pain Relevance 0.16

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