INT131497

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.09
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
renal cortex 3
brainstem 2
medulla 1
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 15 100.00 Very High Very High Very High
Nerve growth factor 9 98.72 Very High Very High Very High
gABA 14 93.64 High High
Root ganglion neuron 1 88.76 High High
depression 1 68.40 Quite High
qutenza 4 60.84 Quite High
Pain 1 57.20 Quite High
Glutamate 9 56.44 Quite High
Bioavailability 2 36.16 Quite Low
antagonist 2 34.40 Quite Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 37 99.30 Very High Very High Very High
Ganglion Cysts 1 88.44 High High
Stress 21 87.76 High High
Pheochromocytoma 1 86.96 High High
Disorders Of Creatine Metabolism 4 80.48 Quite High
Pressure And Volume Under Development 20 75.00 Quite High
Depression 1 68.40 Quite High
Nociception 1 67.60 Quite High
Hypertension 6 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we found a reduction in the mRNA AT1 expression in the brainstem tissue in CRF rats accompanied by a significant increase in the level of p47phox and gp91phox gene expression in the RVLM compared to C group.
Positive_regulation (increase) of Gene_expression (expression) of gp91phox in brainstem associated with medulla and chronic renal failure
1) Confidence 0.01 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.81 Pain Relevance 0.35
Protein expression of NAD(P)H oxidase subunits, including p47(phox) and gp91(phox) in the renal cortex and medulla, was significantly increased in CAP-HS compared with CON-HS, CON-NS, and CAP-NS rats.
Positive_regulation (increased) of in medulla Gene_expression (expression) of gp91 in renal cortex associated with medulla
2) Confidence 0.01 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16920809 Disease Relevance 0.52 Pain Relevance 0.25
NGF stimulated NADPH oxidase activity, while 24 h exposure further increased expression of the Rac1 and gp91(phox) subunits of the holoenzyme.
Positive_regulation (increased) of Gene_expression (expression) of gp91 associated with nerve growth factor
3) Confidence 0.01 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.24 Pain Relevance 0.46
Protein expression of NAD(P)H oxidase subunits, including p47(phox) and gp91(phox) in the renal cortex and medulla, was significantly increased in CAP-HS compared with CON-HS, CON-NS, and CAP-NS rats.
Positive_regulation (increased) of Gene_expression (expression) of gp91 in renal cortex associated with medulla
4) Confidence 0.00 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16920809 Disease Relevance 0.52 Pain Relevance 0.25

General Comments

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