INT131498

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 8.73
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb)
plasma membrane (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
PSCs 2
plasma 1
aorta 1
smooth muscle 1
medulla 1
Cybb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 36 98.76 Very High Very High Very High
Nerve growth factor 9 98.52 Very High Very High Very High
Chronic pancreatitis 4 98.12 Very High Very High Very High
gABA 56 92.16 High High
Root ganglion neuron 1 88.36 High High
chemokine 2 84.64 Quite High
Inflammation 36 76.32 Quite High
Spinal cord 6 75.00 Quite High
antagonist 29 74.40 Quite High
fibrosis 21 69.12 Quite High
Disease Link Frequency Relevance Heat
Chronic Renal Failure 148 99.20 Very High Very High Very High
Pancreatitis 4 98.12 Very High Very High Very High
Injury 22 97.40 Very High Very High Very High
Targeted Disruption 7 95.24 Very High Very High Very High
Hypertension 128 95.08 Very High Very High Very High
Necrosis 8 94.92 High High
Cancer 8 94.56 High High
Pressure And Volume Under Development 80 91.80 High High
Urological Neuroanatomy 5 91.48 High High
Stroke 12 90.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSCs expressed key components of NADPH oxidase (p22(phox), p47(phox), NOX1, gp91(phox)/NOX2, NOX4, and NOX activator 1).
Gene_expression (expressed) of NOX2 in PSCs
1) Confidence 0.40 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962358 Disease Relevance 0.51 Pain Relevance 0.30
PSCs expressed key components of NADPH oxidase (p22(phox), p47(phox), NOX1, gp91(phox)/NOX2, NOX4, and NOX activator 1).
Gene_expression (expressed) of gp91 in PSCs
2) Confidence 0.35 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962358 Disease Relevance 0.51 Pain Relevance 0.30
In the present study, we have shown that aldosterone treatment induced overexpression of two membrane-bound elements (p22phox and gp91phox) and one cytosolic component (p47phox) of the NAD(P)H oxidase and its activity, and led to the translocation of the cytosolic p47phox to the plasma membrane in aorta and kidney.
Gene_expression (overexpression) of gp91phox in plasma
3) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0
Aortic expression of the subunits p47phox, gp91phox, and p22phox increased in aldosterone-infused rats by 5.5, 4.7, and 3.2-fold, respectively, which was decreased completely by spironolactone and partially by losartan and apocynin.
Gene_expression (expression) of gp91phox
4) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2610641 Disease Relevance 0.32 Pain Relevance 0
Aldosterone-salt rats showed significantly higher p47phox and gp91phox expression in aorta than that of control rats.
Gene_expression (expression) of gp91phox in aorta
5) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
In kidney, aldosterone-salt rats showed significantly higher p47phox, gp91phox, and p22phox expression than that of control rats.
Gene_expression (expression) of gp91phox in kidney
6) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0 Pain Relevance 0
Although p22phox alone does not support superoxide production but it has been clearly shown to stabilize the expression of gp91phox (20) and Nox1 (21) in culture, probably serving as a stabilizing and/or regulatory subunit. p22phox overexpression in transgenic (Tg) mice (Tgp22smc) that overexpress the p22phox subunit of NAD(P)H oxidase selectively in smooth muscle, concomitantly upregulates Nox1, and potentates angiotensin II induced vascular hypertrophy (22).
Gene_expression (expression) of gp91phox in smooth muscle associated with targeted disruption and hypertrophy
7) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.58 Pain Relevance 0
Similarly, aldosterone infusion showed elevated renal tissue ROS levels which were associated with increased mRNA expression of p22phox, Nox-4, and gp91phox (10).
Gene_expression (expression) of gp91phox
8) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.03
Furthermore, we demonstrated that aldosterone activated NAD(P)H oxidase and increased the expression of membrane-bound elements (p22phox and gp91phox) and cytosolic components (p47phox) of the enzyme, which may be linked to cardio-vascular-renal damage.
Gene_expression (expression) of gp91phox
9) Confidence 0.02 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.58 Pain Relevance 0.03
In cord homogenates, BIO5192 treatment decreased expression of the oxidative enzymes gp91(phox), inducible nitric oxide and cyclooxygenase-2 by approximately 40% at both times of analysis.
Gene_expression (expression) of gp91
10) Confidence 0.02 Published 2008 Journal Exp. Neurol. Section Abstract Doc Link 18926823 Disease Relevance 0.79 Pain Relevance 0.17
In the present study, we found a reduction in the mRNA AT1 expression in the brainstem tissue in CRF rats accompanied by a significant increase in the level of p47phox and gp91phox gene expression in the RVLM compared to C group.
Gene_expression (expression) of gp91phox in brainstem associated with medulla and chronic renal failure
11) Confidence 0.02 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.76 Pain Relevance 0.34
According to the real-time PCR, the level of p47phox and gp91phox gene expression in the RVLM in the CRF group was significantly higher than in the C group ((p47phox-CRF, 33.07 ± 5.47 and C, 1.13 ± 0.09 AU; P < .004) and (gp91phox, 14.51 ± 1.49 and C, 1.21 ± 0.28 AU; P < .001)), as shown in Figures 2(b) and 2(c).

3.3.

Gene_expression (expression) of gp91phox associated with chronic renal failure
12) Confidence 0.02 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 1.23 Pain Relevance 0.11
Therefore, the first aim of the present study was to quantify the NADPH p47phox and gp91phox subunits expression within the RVLM.
Gene_expression (expression) of gp91phox
13) Confidence 0.02 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.85 Pain Relevance 0.07
Telmisartan decreases in the aortic levels of the protein expression of gp91, a subunit of NADPH oxidase, resulting in a relief to endothelial dysfunction.43 A blockade on the reninangiotensin-aldosterone system is more beneficial than diuretics in relieving the endothelial dysfunction accounting for an increase in the vasodilating activity.
Gene_expression (expression) of gp91
14) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2941789 Disease Relevance 0.78 Pain Relevance 0.04
NGF stimulated NADPH oxidase activity, while 24 h exposure further increased expression of the Rac1 and gp91(phox) subunits of the holoenzyme.
Gene_expression (expression) of gp91 associated with nerve growth factor
15) Confidence 0.01 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16283857 Disease Relevance 0.24 Pain Relevance 0.46
Protein expression of NAD(P)H oxidase subunits, including p47(phox) and gp91(phox) in the renal cortex and medulla, was significantly increased in CAP-HS compared with CON-HS, CON-NS, and CAP-NS rats.
Gene_expression (expression) of gp91 in renal cortex associated with medulla
16) Confidence 0.01 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16920809 Disease Relevance 0.40 Pain Relevance 0.24
PCR was performed with primers selective for AT1 receptor, p47phox, and gp91phox (Table 1).
Gene_expression (selective) of gp91phox
17) Confidence 0.01 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0 Pain Relevance 0
Protein expression of NAD(P)H oxidase subunits, including p47(phox) and gp91(phox) in the renal cortex and medulla, was significantly increased in CAP-HS compared with CON-HS, CON-NS, and CAP-NS rats.
Gene_expression (expression) of gp91 in medulla associated with medulla
18) Confidence 0.00 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16920809 Disease Relevance 0.40 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox