INT131527

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.17
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acadvl) lipid metabolic process (Acadvl)
Anatomy Link Frequency
fat 2
muscle 1
Acadvl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 12 96.44 Very High Very High Very High
peripheral neuropathy 1 83.24 Quite High
Disease Link Frequency Relevance Heat
Infection 5 98.16 Very High Very High Very High
Myalgia 11 96.72 Very High Very High Very High
Rhabdomyolysis 10 96.72 Very High Very High Very High
Myoglobinuria 5 96.08 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 84.20 Quite High
Peripheral Neuropathy 1 83.24 Quite High
Body Weight 3 78.76 Quite High
Pain 1 71.48 Quite High
Muscle Weakness 1 71.12 Quite High
Coronary Heart Disease 1 66.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adult onset Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) deficiency has been diagnosed only recently.
Negative_regulation (deficiency) of VLCAD
1) Confidence 0.56 Published 2005 Journal Neuromuscul. Disord. Section Abstract Doc Link 16288870 Disease Relevance 0.45 Pain Relevance 0.09
We discuss the therapeutic mechanism of dantrolene sodium and its possible role as additional treatment modality for patients with VLCAD deficiency.
Negative_regulation (deficiency) of VLCAD
2) Confidence 0.49 Published 2005 Journal Neuromuscul. Disord. Section Abstract Doc Link 16288870 Disease Relevance 0.43 Pain Relevance 0.09
Adult onset Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) deficiency has been diagnosed only recently.
Negative_regulation (deficiency) of Very Long Chain Acyl-CoA Dehydrogenase
3) Confidence 0.49 Published 2005 Journal Neuromuscul. Disord. Section Abstract Doc Link 16288870 Disease Relevance 0.45 Pain Relevance 0.09
Patients with a medium-chain fat-based diet received supplementation of essential long-chain fatty acids. l-Carnitine was supplemented in about half of the patients, but in none of the patients with VLCAD deficiency identified by newborn screening.
Negative_regulation (deficiency) of VLCAD in fat
4) Confidence 0.36 Published 2009 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 19399638 Disease Relevance 0.44 Pain Relevance 0.11
In adults, VLCAD deficiency results in recurrent fasting-, exercise-, or infection-induced muscle stiffness, muscle pain and myoglobinuria caused by rhabdomyolysis.
Negative_regulation (deficiency) of VLCAD in muscle associated with pain, myoglobinuria, rhabdomyolysis, myalgia and infection
5) Confidence 0.36 Published 2005 Journal Neuromuscul. Disord. Section Abstract Doc Link 16288870 Disease Relevance 0.48 Pain Relevance 0.10
This case illustrates for the first time the beneficial effect of dantrolene in VLCAD deficiency.
Negative_regulation (deficiency) of VLCAD
6) Confidence 0.36 Published 2005 Journal Neuromuscul. Disord. Section Abstract Doc Link 16288870 Disease Relevance 0.46 Pain Relevance 0.10
The patient was identified via family screening at the age of 3 years when very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency was diagnosed in his sister by newborn screening.
Negative_regulation (deficiency) of VLCAD
7) Confidence 0.30 Published 2007 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 17457695 Disease Relevance 0.12 Pain Relevance 0.05
Effects of a fat load and exercise on asymptomatic VLCAD deficiency.
Negative_regulation (deficiency) of VLCAD in fat
8) Confidence 0.26 Published 2007 Journal J. Inherit. Metab. Dis. Section Title Doc Link 17457695 Disease Relevance 0.21 Pain Relevance 0.13
The patient was identified via family screening at the age of 3 years when very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency was diagnosed in his sister by newborn screening.
Negative_regulation (deficiency) of very long-chain acyl-CoA dehydrogenase
9) Confidence 0.26 Published 2007 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 17457695 Disease Relevance 0.12 Pain Relevance 0.05

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