INT131542

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.92
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
epithelium 4
adipocytes 2
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 18 98.16 Very High Very High Very High
Inflammation 36 80.80 Quite High
cINOD 1 62.84 Quite High
Central nervous system 15 50.08 Quite High
Spinal cord 9 5.00 Very Low Very Low Very Low
Neuritis 9 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Trigeminal neuralgia 3 5.00 Very Low Very Low Very Low
intrathecal 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 56 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 47 100.00 Very High Very High Very High
Neuromyelitis Optica 243 99.68 Very High Very High Very High
Disease 44 98.60 Very High Very High Very High
Demyelinating Disease 27 98.16 Very High Very High Very High
Neurological Disease 6 94.00 High High
Alzheimer's Dementia 3 93.32 High High
Shock 1 88.24 High High
INFLAMMATION 45 80.80 Quite High
Motor Neuron Diseases 3 67.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, Bernier et al, in collaboration with our laboratory, has demonstrated that overexpression of apoE in adipocytes reduces differentiation as well as the accumulation of cholesterol and triglycerides in these cells [7].
Negative_regulation (reduces) of Gene_expression (overexpression) of apoE in adipocytes associated with obesity
1) Confidence 0.40 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.60 Pain Relevance 0
Some studies of elderly subjects showed either the highest levels of CRP in APOE ?
Negative_regulation (showed) of Gene_expression (levels) of APOE
2) Confidence 0.37 Published 2010 Journal Human Immunology Section Body Doc Link PMC2837141 Disease Relevance 0.32 Pain Relevance 0
-glycoprotein (A1BG), DBP, fibrinogen gamma chain (FGG), pigment epithelium-derived factor (PEDF), apolipoprotein A-IV (ApoA-IV), apolipoprotein E (ApoE), and transthyretin (TTR) were downregulated in the NMO group in comparison to the control group.
Negative_regulation (downregulated) of Gene_expression (chain) of apolipoprotein E in epithelium associated with neuromyelitis optica and disorder of lipid metabolism
3) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.58 Pain Relevance 0
-glycoprotein (A1BG), DBP, fibrinogen gamma chain (FGG), pigment epithelium-derived factor (PEDF), apolipoprotein A-IV (ApoA-IV), apolipoprotein E (ApoE), and transthyretin (TTR) were downregulated in the NMO group in comparison to the control group.
Negative_regulation (downregulated) of Gene_expression (chain) of ApoE in epithelium associated with neuromyelitis optica and disorder of lipid metabolism
4) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.58 Pain Relevance 0
Therefore, reduced levels of ApoE may contribute to the progression of NMO.


Negative_regulation (reduced) of Gene_expression (levels) of ApoE associated with neuromyelitis optica
5) Confidence 0.24 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 1.43 Pain Relevance 0.15
On the other hand, the expression of 19 proteins was changed by ibuprofen and the expression of apolipoprotein E, RNA binding motif 4, CTP-phosphocholine cytidylyltransferase, and phospholipase A2 inhibitory protein was only altered by ibuprofen.
Negative_regulation (altered) of Gene_expression (expression) of apolipoprotein E associated with disorder of lipid metabolism
6) Confidence 0.20 Published 2006 Journal Life Sci. Section Abstract Doc Link 16289138 Disease Relevance 0.39 Pain Relevance 0.17

General Comments

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