INT131552

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC5) ATPase activity (ABCC5) plasma membrane (ABCC5)
transmembrane transport (ABCC5)
Anatomy Link Frequency
skeletal muscle 1
ABCC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 96.12 Very High Very High Very High
Morphine 1 93.28 High High
dexamethasone 1 91.92 High High
Bile 1 58.56 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Biliary Liver Cirrhosis 8 99.32 Very High Very High Very High
Disease 1 98.40 Very High Very High Very High
Overdose 3 96.48 Very High Very High Very High
Toxicity 3 85.72 High High
Breast Cancer 1 78.68 Quite High
Acute Liver Failure 1 75.00 Quite High
Liver Failure 1 67.04 Quite High
Injury 2 59.44 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Muscle Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MRP1, MRP2, MRP5, OAT3, and OAT4 were also detected by RT-PCR.
Gene_expression (detected) of MRP5
1) Confidence 0.50 Published 2005 Journal Brain Res. Section Abstract Doc Link 16289483 Disease Relevance 0 Pain Relevance 0.14
Protein levels of MRP4, MRP5, BCRP, and P-gp were increased in both disease states, with MRP1 and MRP3 protein also being induced in PBC.
Gene_expression (levels) of MRP5 associated with biliary liver cirrhosis and disease
2) Confidence 0.50 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17627974 Disease Relevance 1.29 Pain Relevance 0.56
METHODS AND RESULTS: We demonstrate that the uptake transporter OATP2B1 (human organic anion transporting polypeptide 2B1) and the efflux transporters, multidrug resistance-associated protein (MRP)1, MRP4, and MRP5 are expressed on the sarcolemmal membrane of human skeletal muscle fibers and that atorvastatin and rosuvastatin are substrates of these transporters when assessed using a heterologous expression system.
Gene_expression (expressed) of MRP5 in skeletal muscle
3) Confidence 0.46 Published 2010 Journal Circ. Res. Section Body Doc Link 19940267 Disease Relevance 0.09 Pain Relevance 0

General Comments

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