INT131575

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.31
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1, Ephb1) cytoplasm (Grin1, Ephb1) endosome (Ephb1)
signal transduction (Ephb1) enzyme binding (Grin1)
Anatomy Link Frequency
spinal cord 2
Grin1 (Rattus norvegicus)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
withdrawal 9 100.00 Very High Very High Very High
Kinase C inhibitor 1 100.00 Very High Very High Very High
nMDA receptor 1 100.00 Very High Very High Very High
antagonist 1 100.00 Very High Very High Very High
intrathecal 2 99.98 Very High Very High Very High
Spinal cord 2 99.68 Very High Very High Very High
Morphine 7 98.84 Very High Very High Very High
narcan 4 88.24 High High
allodynia 1 83.44 Quite High
psychological dependence 1 64.56 Quite High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 1 98.24 Very High Very High Very High
Neuropathic Pain 1 83.44 Quite High
Drug Dependence 2 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of the spinal ERK in morphine withdrawal was supported by our finding that intrathecal N-methyl-D-aspartate receptor antagonist MK-801 or protein kinase C inhibitor chelerythrine chloride suppressed withdrawal-induced ERK activation in the spinal cord and attenuated morphine withdrawal symptoms.
N-methyl-D-aspartate receptor Negative_regulation (suppressed) of Positive_regulation (activation) of ERK in spinal cord associated with antagonist, nmda receptor, withdrawal, spinal cord, kinase c inhibitor, intrathecal and morphine
1) Confidence 0.28 Published 2005 Journal Pain Section Abstract Doc Link 16289800 Disease Relevance 0.31 Pain Relevance 1.58

General Comments

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