INT1316

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Context Info
Confidence 0.60
First Reported 1976
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 129
Total Number 134
Disease Relevance 18.86
Pain Relevance 56.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
striatum 12
hippocampus 8
NAC 6
brain 3
cortex 3
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 173 100.00 Very High Very High Very High
Nucleus accumbens 137 100.00 Very High Very High Very High
gABA 42 100.00 Very High Very High Very High
Calcitonin gene-related peptide 12 100.00 Very High Very High Very High
Potency 11 100.00 Very High Very High Very High
Morphine 52 99.98 Very High Very High Very High
Somatostatin 30 99.98 Very High Very High Very High
antagonist 126 99.96 Very High Very High Very High
Glutamate 62 99.92 Very High Very High Very High
Dorsal horn 8 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 1 99.96 Very High Very High Very High
Pain 42 99.82 Very High Very High Very High
Increased Venous Pressure Under Development 120 99.68 Very High Very High Very High
Frailty 197 99.48 Very High Very High Very High
INFLAMMATION 331 99.36 Very High Very High Very High
Multiple System Atrophy 8 99.32 Very High Very High Very High
Urological Neuroanatomy 40 99.28 Very High Very High Very High
Decapitation 13 99.16 Very High Very High Very High
Substance Withdrawal Syndrome 2 99.08 Very High Very High Very High
Morphine Dependence 1 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that haloperidol-induced release of DA is, at least partially, mediated by the activation of muscarinic ACh receptors located in the striatum.
Positive_regulation (activation) of ACh in striatum associated with dopamine
1) Confidence 0.60 Published 1990 Journal Neuropharmacology Section Abstract Doc Link 2304616 Disease Relevance 0 Pain Relevance 0.54
Moreover, oxotremorine, but not pilocarpine, inhibited ACh release in a concentration-dependent manner in either basal- or picric acid-evoked conditions, indicating the presence of muscarinic M2-receptors for auto-regulation of ACh release.
Positive_regulation (auto-regulation) of ACh
2) Confidence 0.50 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2875422 Disease Relevance 0 Pain Relevance 0.23
TTX injected in the caudal ventrolateral medulla (CVLM) inhibited the phenylephrine-induced increase of ACh release.
Positive_regulation (increase) of ACh in medulla associated with medulla and tetrodotoxin
3) Confidence 0.50 Published 1998 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 9533616 Disease Relevance 0.08 Pain Relevance 0.94
Ovariectomy caused the significant increase in both TTX-insensitive basal Ach release and TTX-insensitive stretch-induced Ach release.
Positive_regulation (stretch-induced) of Ach
4) Confidence 0.50 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17480029 Disease Relevance 0.14 Pain Relevance 0
Ovariectomy caused the significant increase in both TTX-insensitive basal Ach release and TTX-insensitive stretch-induced Ach release.
Positive_regulation (increase) of Ach
5) Confidence 0.50 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17480029 Disease Relevance 0.14 Pain Relevance 0
Therefore, the effect of estrogen on 5-HT-stimulated ACh release might be exerted partly via 5-HT(1A) receptors, and not via 5-HT(2) receptors.
Positive_regulation (5-HT-stimulated) of ACh
6) Confidence 0.48 Published 2002 Journal Brain Res. Section Abstract Doc Link 12020863 Disease Relevance 0.29 Pain Relevance 0.19
The addition of 100 mm KCl to the perfusion medium strongly stimulated ACh release, whereas, 0.5 microm tetrodotoxin (TTX) inhibited spontaneous ACh release by more than 50%.
Positive_regulation (stimulated) of ACh associated with tetrodotoxin
7) Confidence 0.48 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11722614 Disease Relevance 0.25 Pain Relevance 0.51
Addition of physostigmine (10 microM) to the perfusion fluid produced about a 100-fold increase in the amount of ACh collected.
Positive_regulation (increase) of ACh
8) Confidence 0.46 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1861156 Disease Relevance 0 Pain Relevance 0.08
When perfused in the MS/VDB, the excitatory amino-acid agonists N-methyl-D-aspartate (NMDA) (100 mumol/l) and kainic acid (10 mumol/l) caused an increase in the extracellular level of ACh in the hippocampus by 83% and 161%, respectively.
Positive_regulation (increase) of ACh in hippocampus associated with agonist and hippocampus
9) Confidence 0.46 Published 1994 Journal Brain Res. Section Abstract Doc Link 7922524 Disease Relevance 0 Pain Relevance 0.66
In the presence of alpha-methyl-p-tyrosine, the NMDA-evoked release of ACh was increased with similar amplitude in morning and afternoon experiments.
Positive_regulation (increased) of ACh
10) Confidence 0.45 Published 2004 Journal Neuroscience Section Abstract Doc Link 14706785 Disease Relevance 0 Pain Relevance 0.67
Non-hypotensive hypovolemia caused by subcutaneous administration of polyethylene glycol (PEG, 30%, 5 ml) elicited significantly increased ACh levels in the region of the SFO.
Positive_regulation (increased) of ACh in SFO associated with pressure volume 2 under development and hypotension
11) Confidence 0.45 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 13679248 Disease Relevance 0.38 Pain Relevance 0.18
The elevation of Ach levels by LY163502 is reversed by dopamine antagonists haloperidol, cis-flupenthixol and metoclopramide.
Positive_regulation (elevation) of Ach associated with dopamine and antagonist
12) Confidence 0.44 Published 1986 Journal Life Sci. Section Abstract Doc Link 3753738 Disease Relevance 0 Pain Relevance 0.61
Drinking caused 18-20% increases in ACh release in both the NAC and STR.
Positive_regulation (increases) of ACh in NAC associated with nucleus accumbens
13) Confidence 0.44 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1573406 Disease Relevance 0 Pain Relevance 0.64
In both sexes the Novelty and Object tests induced an increase in ACh levels with respect to Baseline.
Positive_regulation (increase) of ACh
14) Confidence 0.41 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878722 Disease Relevance 0.21 Pain Relevance 0.28
In accordance with an involvement of the 5-HT1B receptor in the ACh facilitation induced by d-norfenfluramine is the finding that the selective 5-HT1B agonist, CP-93,129, given locally (2, 4 and 8 micrograms/side) does-dependently raised cortical ACh release.
Positive_regulation (induced) of ACh associated with agonist
15) Confidence 0.41 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627564 Disease Relevance 0.42 Pain Relevance 0.31
Feeding caused a 38% increase in extracellular ACh in the NAC and no change in the STR or HIPP.
Positive_regulation (increase) of ACh in STR associated with nucleus accumbens and hippocampus
16) Confidence 0.41 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1573406 Disease Relevance 0 Pain Relevance 0.66
In a separate experiment, ACh release in the NAC was monitored in 10-min intervals during free-feeding; ACh increased in the interval immediately following maximal food intake.
Positive_regulation (increased) of ACh in NAC associated with nucleus accumbens
17) Confidence 0.41 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1573406 Disease Relevance 0 Pain Relevance 0.61
The stimulating effect of KW-6055 on ACh release was abolished by tetrodotoxin treatment, supporting that the released ACh was due to neuronal firing.
Positive_regulation (due) of ACh in neuronal associated with tetrodotoxin
18) Confidence 0.41 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1398340 Disease Relevance 0.09 Pain Relevance 0.10
We examined the effect of KW-6055 [alpha-(p-butyrylamino-o-nitrobenzyl) pyridine], which has anti-amnesic activity, on the central cholinergic systems of rat frontal cortex using in vivo brain microdialysis. 1) KW-6055 (40, 160 mg/kg, p.o.) increased the extracellular level of ACh in normal rats (257 +/- 23, 202 +/- 24%).
Positive_regulation (increased) of ACh in brain associated with urological neuroanatomy
19) Confidence 0.41 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1398340 Disease Relevance 0.10 Pain Relevance 0.09
Reserpine pretreatment decreased the effect of KW-6055, indicating that KW-6055 acted on cholinergic neurons through catecholaminergic neurons. 2) In basal forebrain-lesioned rats, KW-6055 (40 mg/kg, p.o.) significantly increased the extracellular level of ACh (251 +/- 22%) for more than 2 hr, which was longer than in normal rats.
Positive_regulation (increased) of ACh in cholinergic neurons
20) Confidence 0.41 Published 1992 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1398340 Disease Relevance 0.08 Pain Relevance 0.09

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