INT131612

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.91
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
fat 1
mast cell 1
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 90.32 High High
Inflammatory response 7 72.88 Quite High
Inflammation 43 53.52 Quite High
substance P 3 49.12 Quite Low
agonist 1 23.60 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
interstitial cystitis 4 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 23 100.00 Very High Very High Very High
Melanoma 146 99.84 Very High Very High Very High
Metastasis 26 95.32 Very High Very High Very High
Cancer 91 95.04 Very High Very High Very High
Pain 4 90.32 High High
Aggression 4 85.16 High High
Leukemia 1 82.96 Quite High
Anxiety Disorder 1 81.00 Quite High
Renal Cancer 3 77.80 Quite High
Disease 8 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is consistent with the work of other investigators that showed reduced levels of MITF was associated with increased invasiveness in melanoma cells [27], whereas MITF over-expression suppressed melanoma metastasis in mouse xenograft tumours [28].
Negative_regulation (reduced) of MITF associated with cancer, melanoma and metastasis
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.34 Pain Relevance 0
BRN2 has been reported to be a negative regulator of MITF in melanoma cells [22], yet we were unable to show any correlation between MITF and BRN2 transcription in this study, with any potential correlation tending towards positive rather than negative at the transcript level.
Negative_regulation (regulator) of MITF associated with melanoma
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.07 Pain Relevance 0
Mice deficient in MiTF harbor a severe mast cell deficiency, and MiTF-mutant mast cells cultured ex vivo display a number of functional defects [60].
Negative_regulation (deficient) of MiTF in mast cell associated with microphthalmia
3) Confidence 0.28 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.24 Pain Relevance 0.06
Nonhormonal therapy like reassurance, breast support, reduction in dietary fat intake, VitE, Vit B6 was preferred for initial therapy of mastalgia as it was found to be associated with improvements of cyclical mastalgia and good compliance.
Negative_regulation (reduction) of VitE in fat
4) Confidence 0.03 Published 2004 Journal Nepal Med Coll J Section Abstract Doc Link 16295745 Disease Relevance 0.25 Pain Relevance 0.17

General Comments

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