INT131639

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.22
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (P2rx3)
Anatomy Link Frequency
nerve 2
P2rx3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 8 98.96 Very High Very High Very High
Neuropathic pain 3 85.48 High High
nMDA receptor 1 85.36 High High
adenocard 1 81.80 Quite High
allodynia 3 70.68 Quite High
Pain 6 70.16 Quite High
Neurotransmitter 1 68.96 Quite High
dorsal root ganglion 33 64.96 Quite High
antagonist 1 56.00 Quite High
Kinase C 72 55.92 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 10 96.00 Very High Very High Very High
Neuropathic Pain 8 85.48 High High
Nociception 15 80.80 Quite High
Pathologic Processes 1 77.52 Quite High
Pain 6 70.16 Quite High
Ganglion Cysts 33 64.96 Quite High
Injury 2 54.24 Quite High
Hepatitis 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the enhancement of trafficking of P2X3 receptors is likely an important mechanism contributing to the increase in receptor function after nerve injury.
Positive_regulation (enhancement) of P2X3 Binding (trafficking) of in nerve associated with nervous system injury
1) Confidence 0.47 Published 2005 Journal Pain Section Abstract Doc Link 16298067 Disease Relevance 0.78 Pain Relevance 0.37
We cannot rule out, however, the possibility that phosphoinositide binding requires the intact P2X3 receptor subunit.
Positive_regulation (requires) of P2X3 Binding (binding) of
2) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734547 Disease Relevance 0.13 Pain Relevance 0.08
A peculiar phenotype is inherent to heteromeric P2X2/P2X3 (P2X2+3) receptors, which feature ??
Positive_regulation (inherent) of P2X3 Binding (heteromeric) of
3) Confidence 0.23 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072911 Disease Relevance 0.30 Pain Relevance 0.22

General Comments

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