INT131646

Context Info Confidence 0.21 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.35 Pain Relevance 0.80

extracellular space (Ngf, Calca) extracellular region (Ngf, Calca) signal transduction (Ngf) nucleus (Calca) intracellular (Calca) cytoplasm (Calca)

Anatomy Link Frequency nerve 2 Ngf (Mus musculus) Calca (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 4 100.00 Calcitonin gene-related peptide 4 100.00 qutenza 3 82.92 Spinal cord 1 79.00 Neuropeptide 5 77.24 substance P 2 71.68 Pain 1 68.48 Lasting pain 1 44.48 neuralgia 3 25.00

Disease Link Frequency Relevance Heat Disease 2 80.00 Neurofibromatosis 3 79.36 Pain 2 68.48 Nociception 2 60.76 Malignant Neoplastic Disease 1 42.24

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

When nerve growth factor was removed 48 h before conducting release experiments, nerve growth factor-induced augmentation of immunoreactive calcitonin gene-related peptide release from Nf1+/- neurons was more pronounced than in Nf1+/- sensory neurons that were treated with nerve growth factor continuously for 5-7 days.

nerve growth factor Positive_regulation (augmentation) of Localization (release) of calcitonin in nerve associated with nerve growth factor and calcitonin gene-related peptide

1) Confidence 0.21 Published 2006 Journal Neuroscience Section Abstract Doc Link 16298082 Disease Relevance 0.35 Pain Relevance 0.80

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