INT1317

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 24
Disease Relevance 6.97
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sds) lyase activity (Sds) cellular_component (Sds)
cellular amino acid metabolic process (Sds) cytoplasm (Sds)
Anatomy Link Frequency
diaphragm 3
plasma 2
nerves 2
ovary 2
liver 1
Sds (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 17 100.00 Very High Very High Very High
tetrodotoxin 16 99.82 Very High Very High Very High
Dynorphin 4 99.70 Very High Very High Very High
Pain 14 98.92 Very High Very High Very High
Morphine 4 96.84 Very High Very High Very High
Spinal cord 15 96.70 Very High Very High Very High
Paracetamol 9 96.54 Very High Very High Very High
adenocard 2 95.32 Very High Very High Very High
palliative 12 93.52 High High
Opioid 1 92.48 High High
Disease Link Frequency Relevance Heat
Depression 39 100.00 Very High Very High Very High
Fever 2 99.84 Very High Very High Very High
Melanoma 2 99.68 Very High Very High Very High
Cancer 72 99.42 Very High Very High Very High
Gallbladder Neoplasms 2 99.30 Very High Very High Very High
Ovarian Cancer 2 99.08 Very High Very High Very High
Pancreatic Cancer 2 99.00 Very High Very High Very High
Pain 13 98.92 Very High Very High Very High
Toxicity 10 98.86 Very High Very High Very High
Endometrial Cancer 2 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma obtained during and after PGI2 infusion did not decrease mitochondrial SDH activity, which remained higher than that in controls (P less than 0.001); mitochondrial respiration was also not altered.
Neg (not) Negative_regulation (decrease) of SDH in Plasma
1) Confidence 0.48 Published 1982 Journal Surgery Section Abstract Doc Link 7046119 Disease Relevance 0.26 Pain Relevance 0.13
Dog plasma obtained 2 to 5 hours after endotoxin infusion, incubated with rat or dog myocardial mitochondria, decreased succinate dehydrogenase (SDH) activity (P less than 0.05) and depressed mitochondrial respiration in the presence of the substrate succinate and adenosine diphosphate (ADP) from 180 to 87 Natoms oxygen/mg protein . min (P less than 0.05).
Negative_regulation (decreased) of SDH in plasma associated with adenocard
2) Confidence 0.48 Published 1982 Journal Surgery Section Abstract Doc Link 7046119 Disease Relevance 0.14 Pain Relevance 0.13
APAP toxicity in liver slices (% glutathione-S-transferase alpha released to the medium, GST release) and NAPQI toxicity in isolated liver mitochondria (succinate dehydrogenase inactivation, SDH) from these rats were compared with pair-fed controls.
Negative_regulation (inactivation) of SDH in liver associated with toxicity and paracetamol
3) Confidence 0.41 Published 2002 Journal Hepatology Section Abstract Doc Link 12143040 Disease Relevance 0.51 Pain Relevance 0.58
In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I, IIa, and IIx fibers (approximately 50, 70, and 24%, respectively) and a decrease in SDH variability among fibers (approximately 63%).
Negative_regulation (reduction) of SDH in nerve associated with tetrodotoxin
4) Confidence 0.41 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9104851 Disease Relevance 0 Pain Relevance 0.20
We also found that daily CNTF administration counteracted the denervation-associated loss of SDH activity exclusively within the intermyofibrillar compartment, suggesting that CNTF treatment mimics the effects of activity on SDH levels within the core region of denervated fibers, but under these conditions does not influence the endplate accumulation of this enzyme.
Negative_regulation (loss) of SDH
5) Confidence 0.40 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8769787 Disease Relevance 0 Pain Relevance 0.23
Using quantitative microphotometry, we found that daily stimulation of quiescent but intact nerves prevented the TTX-induced decrease in SDH activity within extrajunctional regions, whereas, at the endplate, the counteraction was partial (30%).
Negative_regulation (decrease) of SDH in nerves associated with tetrodotoxin
6) Confidence 0.40 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8769787 Disease Relevance 0 Pain Relevance 0.27
Both doses of dynorphin significantly reduced SDH activity at 1 and 4 hr after treatment.
Negative_regulation (reduced) of SDH associated with dynorphin
7) Confidence 0.39 Published 1996 Journal Indian J. Exp. Biol. Section Abstract Doc Link 8698427 Disease Relevance 0 Pain Relevance 0.61
Tetrodotoxin could block initial epileptiform bursting, without blocking SDs.
Negative_regulation (blocking) of SDs associated with tetrodotoxin and depression
8) Confidence 0.38 Published 2000 Journal J. Neurophysiol. Section Abstract Doc Link 10980008 Disease Relevance 1.16 Pain Relevance 0.14
The combined cohort of patients in both age groups showed a significant decrease in QOL over time (mean decrease of 7.9, P = 0.02), a decrease in pain frequency (mean improvement of 0.4, P = 0.02), and a decrease in SDS outlook (mean decrease ?
Negative_regulation (decrease) of SDS associated with pain
9) Confidence 0.37 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004576 Disease Relevance 0.39 Pain Relevance 0.10
The combined cohort of patients in both age groups showed a significant decrease in QOL over time (mean decrease of 7.9, P = 0.02), a decrease in pain frequency (mean improvement of 0.4, P = 0.02), and a decrease in SDS outlook (mean decrease ?
Negative_regulation (decrease) of SDS associated with pain
10) Confidence 0.37 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004576 Disease Relevance 0.40 Pain Relevance 0.10
Removal of SDS was possible in the final step.
Negative_regulation (Removal) of SDS
11) Confidence 0.37 Published 1981 Journal J. Chromatogr. Section Abstract Doc Link 7276115 Disease Relevance 0 Pain Relevance 0
The statistical evaluation presents that patients with cancer of lung, with cancer of endometrium, with cancer of gallbladder and with melanomas are moderately depressed (SDS 60-69), patients with cancer of ovary, with cancer of breast, with primary brain tumour, with cancer of ventricle, with cancer of pancreas head and with cancer of bucall cavity are mildly depressed (SDS 50-59).
Negative_regulation (depressed) of SDS in ovary associated with lung cancer, melanoma, breast cancer, ovarian cancer, gallbladder neoplasms, cancer, pancreatic cancer, endometrial cancer and brain tumor
12) Confidence 0.37 Published 2009 Journal Neoplasma Section Abstract Doc Link 19309220 Disease Relevance 1.60 Pain Relevance 0.52
The statistical evaluation presents that patients with cancer of lung, with cancer of endometrium, with cancer of gallbladder and with melanomas are moderately depressed (SDS 60-69), patients with cancer of ovary, with cancer of breast, with primary brain tumour, with cancer of ventricle, with cancer of pancreas head and with cancer of bucall cavity are mildly depressed (SDS 50-59).
Negative_regulation (depressed) of SDS in ovary associated with lung cancer, melanoma, breast cancer, ovarian cancer, gallbladder neoplasms, cancer, pancreatic cancer, endometrial cancer and brain tumor
13) Confidence 0.37 Published 2009 Journal Neoplasma Section Abstract Doc Link 19309220 Disease Relevance 1.66 Pain Relevance 0.59
In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I, IIa, and IIx fibers (approximately 50, 70, and 24%, respectively) and a decrease in SDH variability among fibers (approximately 63%).
Negative_regulation (decrease) of SDH in diaphragm associated with tetrodotoxin
14) Confidence 0.30 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9104851 Disease Relevance 0 Pain Relevance 0.21
Particularly noteworthy was a marked change in the energy pathways consisting of a decreased activity of aerobic pathways (decreased SDH activity), increased anaerobic activity (increased LDH activity), and consequently, decreased cellular energy stores (decreased ATPase activity).
Negative_regulation (decreased) of SDH
15) Confidence 0.30 Published 1989 Journal Arch. Esp. Urol. Section Abstract Doc Link 2533859 Disease Relevance 0 Pain Relevance 0.29
In rat diaphragm muscle (Dia(m)), 2 wk of unilateral denervation or tetrodotoxin nerve blockade resulted in a reduction in succinate dehydrogenase (SDH) activity of type I, IIa, and IIx fibers (approximately 50, 70, and 24%, respectively) and a decrease in SDH variability among fibers (approximately 63%).
Negative_regulation (decrease) of SDH in diaphragm associated with tetrodotoxin
16) Confidence 0.30 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9104851 Disease Relevance 0 Pain Relevance 0.21
In contrast, inactivity induced by spinal cord hemisection at C2 (ST) resulted in much less change in SDH activity of type I and IIa fibers (approximately 27 and 24%, respectively) and only an approximately 30% reduction in SDH variability among fibers.
Negative_regulation (reduction) of SDH in spinal cord associated with spinal cord
17) Confidence 0.26 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9104851 Disease Relevance 0 Pain Relevance 0.22
Enzymatic activities (SDH, ATPase and phosphorylase) of the damaged part were lost 3 days after crushing and recovered slowly between 7-10 days of regeneration of the diaphragm muscle fibres. 3.
Negative_regulation (lost) of SDH in diaphragm
18) Confidence 0.21 Published 1976 Journal Pflugers Arch. Section Abstract Doc Link 188011 Disease Relevance 0.34 Pain Relevance 0.27
hrs, CPC-2 suppressed SDH activity by >55% relative to the Teflon Control, and then showed some tendency toward an increase in SDH activity with time (48?
Negative_regulation (suppressed) of SDH
19) Confidence 0.21 Published 2010 Journal International Journal of Biomaterials Section Body Doc Link PMC2927743 Disease Relevance 0.20 Pain Relevance 0.03
Hydroxyapatite cement suppressed SDH activity by 33%, and 85% relative to the Teflon negative control after 24?
Negative_regulation (suppressed) of SDH
20) Confidence 0.21 Published 2010 Journal International Journal of Biomaterials Section Body Doc Link PMC2927743 Disease Relevance 0.23 Pain Relevance 0.04

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