INT13170

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Context Info
Confidence 0.74
First Reported 1989
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 8.68
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
cartilage 6
plasma 3
acinar cell 3
PGE1 1
pancreas 1
Comp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 39 100.00 Very High Very High Very High
Pain 16 99.84 Very High Very High Very High
anesthesia 16 98.70 Very High Very High Very High
Morphine 3 98.12 Very High Very High Very High
Osteoarthritis 25 97.84 Very High Very High Very High
Snapping jaw 9 97.44 Very High Very High Very High
fibrosis 6 96.32 Very High Very High Very High
imagery 3 92.72 High High
Inflammation 31 92.40 High High
opiate 1 91.52 High High
Disease Link Frequency Relevance Heat
Pancreatitis 45 100.00 Very High Very High Very High
Pain 15 99.84 Very High Very High Very High
Relapsing Polychondritis 62 99.40 Very High Very High Very High
Synovitis 1 99.40 Very High Very High Very High
Hypotension 4 98.48 Very High Very High Very High
Pancreatic Cancer 15 98.44 Very High Very High Very High
Osteoarthritis 40 97.84 Very High Very High Very High
Temporomandibular Joint Syndrome 9 97.44 Very High Very High Very High
Frailty 6 96.80 Very High Very High Very High
Fibrosis 6 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we characterized COMP mRNA and protein expression in the normal pancreas, chronic pancreatitis, and pancreatic cancer tissues.
Gene_expression (expression) of COMP mRNA in pancreas associated with pancreatic cancer and chronic pancreatitis
1) Confidence 0.74 Published 2003 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 12678339 Disease Relevance 1.04 Pain Relevance 0.53
Cartilage oligomeric matrix protein (COMP) is a member of the thrombospondin (TSP) family of extracellular glycoproteins that is expressed in CP tissues.
Gene_expression (expressed) of COMP in Cartilage associated with chronic pancreatitis
2) Confidence 0.74 Published 2003 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 12678339 Disease Relevance 0.89 Pain Relevance 0.54
COMP protein was also present in the fibrotic tissue in CP.
Gene_expression (present) of COMP protein
3) Confidence 0.74 Published 2003 Journal Scand. J. Gastroenterol. Section Body Doc Link 12678339 Disease Relevance 0.15 Pain Relevance 0
In contrast, COMP expression was weak to absent in the cytoplasm of cancer cells in pancreatic cancer tissues, and in ductal cells and islet cells in normal pancreatic tissues.
Neg (absent) Gene_expression (expression) of COMP
4) Confidence 0.74 Published 2003 Journal Scand. J. Gastroenterol. Section Body Doc Link 12678339 Disease Relevance 0.14 Pain Relevance 0
RESULTS: COMP mRNA and protein were detected at moderate to high levels in chronic pancreatitis tissues, at moderate levels in pancreatic cancer tissues, but at low levels in normal pancreatic tissues and in four pancreatic cancer cell lines.
Gene_expression (detected) of COMP mRNA
5) Confidence 0.64 Published 2003 Journal Scand. J. Gastroenterol. Section Body Doc Link 12678339 Disease Relevance 0.18 Pain Relevance 0
The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy.
Gene_expression (detectable) of COMP in cartilage associated with snapping jaw and osteoarthritis
6) Confidence 0.60 Published 1997 Journal Eur. J. Oral Sci. Section Abstract Doc Link 9298370 Disease Relevance 0.38 Pain Relevance 0.23
The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy.
Gene_expression (detectable) of cartilage oligomeric matrix protein in cartilage associated with snapping jaw and osteoarthritis
7) Confidence 0.60 Published 1997 Journal Eur. J. Oral Sci. Section Abstract Doc Link 9298370 Disease Relevance 0.38 Pain Relevance 0.23
Aggrecan and COMP were detectable in all but 2 fluids, in which the COMP levels were below detection limit.
Gene_expression (detectable) of COMP
8) Confidence 0.52 Published 1997 Journal Eur. J. Oral Sci. Section Abstract Doc Link 9298370 Disease Relevance 0.48 Pain Relevance 0.27
In addition, the serum levels of COMP correlated positively with the extent of bone scan abnormalities (N = 38), r = 0.56, P = 0.002.
Gene_expression (levels) of COMP
9) Confidence 0.52 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 9616437 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: In individuals with knee pain, serum levels of COMP and BSP differ between those with or without bone scan abnormalities in the knee joints.
Gene_expression (levels) of COMP in knee
10) Confidence 0.52 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 9616437 Disease Relevance 0 Pain Relevance 0
Serum levels of COMP and BSP were measured by immunoassays.
Gene_expression (levels) of COMP
11) Confidence 0.52 Published 1998 Journal Osteoarthr. Cartil. Section Body Doc Link 9616437 Disease Relevance 0 Pain Relevance 0
CONCLUSION: COMP is preferentially expressed in degenerating acinar cells in CP and in CP-like areas in pancreatic cancer, suggesting a potential role of this gene in the course of acinar cell degeneration and dedifferentiation.
Gene_expression (expressed) of COMP in acinar cell
12) Confidence 0.50 Published 2003 Journal Scand. J. Gastroenterol. Section Body Doc Link 12678339 Disease Relevance 0.13 Pain Relevance 0
Changes in serum levels of COMP and BSP are potential tools in studies of knee joint OA in subjects with chronic knee pain.
Gene_expression (levels) of COMP in knee joint associated with pain and osteoarthritis
13) Confidence 0.43 Published 1998 Journal Br. J. Rheumatol. Section Abstract Doc Link 9487250 Disease Relevance 0.89 Pain Relevance 0.51
In contrast, COMP expression was weak to absent in the cytoplasm of cancer cells in pancreatic cancer tissues, and in ductal cells and islet cells in normal pancreatic tissues.
Neg (absent) Gene_expression (expression) of COMP
14) Confidence 0.33 Published 2003 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 12892583 Disease Relevance 0.16 Pain Relevance 0
COMP is expressed in auricular, tracheal and nasal cartilage and consequently has the potential to trigger an immune response directed against all these cartilaginous structures [29].
Gene_expression (expressed) of COMP in nasal cartilage
15) Confidence 0.33 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128937 Disease Relevance 0.83 Pain Relevance 0.17
Expression of Cartilage Oligomeric Matrix Protein (COMP)
Gene_expression (Expression) of Cartilage Oligomeric Matrix Protein in Cartilage
16) Confidence 0.31 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687122 Disease Relevance 0 Pain Relevance 0
RESULTS: COMP mRNA signals and immunoreactivity were strongly present in the cytoplasm of degenerating acinar cells in CP tissues as well as in CP-like lesions in pancreatic cancer tissues.
Gene_expression (present) of COMP in acinar cells
17) Confidence 0.29 Published 2003 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 12892583 Disease Relevance 0.18 Pain Relevance 0
CONCLUSION: COMP is preferentially expressed in degenerating acinar cells in CP and in CP-like areas in pancreatic cancer, suggesting a potential role of this molecular in acinar cell dysfunction in CP.


Gene_expression (expressed) of COMP in acinar cell
18) Confidence 0.29 Published 2003 Journal Zhonghua Wai Ke Za Zhi Section Body Doc Link 12892583 Disease Relevance 0.15 Pain Relevance 0
During treatment with nimesulide, in addition to clinical improvement and less pain, serum levels of MMP-3, MMP-8 and COMP fell indicating a beneficial effect on cartilage catabolism.
Gene_expression (levels) of COMP in cartilage associated with pain
19) Confidence 0.28 Published 2002 Journal Int J Clin Pract Suppl Section Abstract Doc Link 12166616 Disease Relevance 0.66 Pain Relevance 0.58
Recent evidence from other laboratories also indicates that glypican-3 (GPC3), vimentin (VIM), pleiotrophin heparin binding factor (PTN), matrix gla protein (MGP), cartilage oligomeric matrix protein (COMP), and keratin 19 (KRT 19) are differently expressed in rat NP cells than are AF and articular cartilage cells [26], suggesting that these genes can be used as markers to distinguish NP cells from hyaline cartilage.
Gene_expression (expressed) of cartilage oligomeric matrix protein in cartilage associated with osteoarthritis
20) Confidence 0.27 Published 2008 Journal The Open Orthopaedics Journal Section Body Doc Link PMC2687122 Disease Relevance 0.27 Pain Relevance 0.04

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