INT131717

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Context Info
Confidence 0.55
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 14.25
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
hepatocytes 4
spinal cord 4
hippocampus 4
fat 2
microglia 2
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 7 99.98 Very High Very High Very High
Spinal cord 68 99.88 Very High Very High Very High
Paracetamol 33 99.48 Very High Very High Very High
Hippocampus 28 99.20 Very High Very High Very High
Inflammation 387 98.04 Very High Very High Very High
cytokine 112 93.40 High High
analgesia 6 91.92 High High
Pain 43 91.36 High High
withdrawal 2 90.60 High High
cINOD 21 90.48 High High
Disease Link Frequency Relevance Heat
Cancer 422 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Disease 154 99.84 Very High Very High Very High
Congenital Anomalies 5 99.84 Very High Very High Very High
INFLAMMATION 413 99.82 Very High Very High Very High
Lung Injury 62 99.76 Very High Very High Very High
Sprains And Strains 120 99.18 Very High Very High Very High
Toxicity 14 99.08 Very High Very High Very High
Adenocarcinoma 11 98.80 Very High Very High Very High
Targeted Disruption 69 98.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most studies show that JNK expression or activation is increased in neoplastic cells [3].
Positive_regulation (increased) of Gene_expression (expression) of JNK
1) Confidence 0.55 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.91 Pain Relevance 0.03
An interesting sidebar to the use of transgenic adenocarcinoma of mouse prostate (TRAMP) mice by Uzgare et al showed that JNK expression can increase in poorly differentiated tumors without an apparent increase in activation.
Positive_regulation (increase) of Gene_expression (expression) of JNK associated with adenocarcinoma, targeted disruption and cancer
2) Confidence 0.55 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.97 Pain Relevance 0.04
JNK adenovirus overexpression increases serine phosphorylation of IRS-1 with decreased IRS-1 tyrosine phosphorylation and increased SREBP-1c activation, resulting in increased fat synthesis and storage.
Positive_regulation (overexpression) of Gene_expression (overexpression) of JNK in fat
3) Confidence 0.51 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.71 Pain Relevance 0.08
One possible factor would be the protein's high stability resulting in a low turnover rate, as JNK1 is constitutively expressed in the spinal cord [21].
Positive_regulation (stability) of Gene_expression (expressed) of JNK1 in spinal cord associated with spinal cord
4) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2831877 Disease Relevance 0.38 Pain Relevance 0.29
Smoke-induced mucus production in the airway of mice through JNK activation
Positive_regulation (induced) of Gene_expression (activation) of JNK
5) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.16 Pain Relevance 0
Smoke-induced mucus production in the airway of mice through JNK activation
Positive_regulation (through) of Gene_expression (activation) of JNK
6) Confidence 0.50 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.16 Pain Relevance 0
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
Positive_regulation (mediated) of Gene_expression (Role) of JNK in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
7) Confidence 0.48 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.43 Pain Relevance 0.86
Role of c-Jun N-terminal kinase (JNK) in regulating tumor necrosis factor-alpha (TNF-alpha) mediated increase of acetaminophen (APAP) and chlorpromazine (CPZ) toxicity in murine hepatocytes.
Positive_regulation (mediated) of Gene_expression (Role) of c-Jun N-terminal kinase in hepatocytes associated with toxicity, necrosis, paracetamol and cancer
8) Confidence 0.48 Published 2010 Journal J Toxicol Sci Section Title Doc Link 20371967 Disease Relevance 1.43 Pain Relevance 0.86
Studies using additional strains of mice confirmed that spinal cord mRNA expression levels of Mapk8 followed the pattern predicted by strain-specific levels of formalin behavior.
Positive_regulation (followed) of Gene_expression (expression) of Mapk8 in spinal cord associated with sprains and strains and spinal cord
9) Confidence 0.47 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2831877 Disease Relevance 0.64 Pain Relevance 0.53
The levels of phosphorylated JNK and p38 MAPK were increased following mechanical ventilation (20 ml/kg, 4 hours), as determined by Western immunoblot analyses of corresponding phospho- and dephospho- forms (Figure 4A and B).
Positive_regulation (increased) of Gene_expression (levels) of JNK
10) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.86 Pain Relevance 0.11
Transfection with JNK siRNA attenuated APAP toxicity after 24 h, suggesting that higher levels of APAP-induced activation of JNK were related to higher rates of cell death.
Positive_regulation (Transfection) of Gene_expression (Transfection) of JNK associated with toxicity, paracetamol and death
11) Confidence 0.45 Published 2010 Journal Toxicol. Sci. Section Abstract Doc Link 20363829 Disease Relevance 0.36 Pain Relevance 0.86
Expression and activation of JNK in tissue
Positive_regulation (activation) of Gene_expression (Expression) of JNK
12) Confidence 0.40 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.90 Pain Relevance 0
Results of JNK activation
Positive_regulation (Results) of Gene_expression (activation) of JNK
13) Confidence 0.40 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.70 Pain Relevance 0.09
Most studies show that JNK expression or activation is increased in neoplastic cells [3].
Positive_regulation (increased) of Gene_expression (expression) of JNK
14) Confidence 0.40 Published 2004 Journal Cell Commun Signal Section Body Doc Link PMC449737 Disease Relevance 0.91 Pain Relevance 0.03
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Positive_regulation (induced) of Gene_expression (expression) of JNK in hippocampus associated with hippocampus
15) Confidence 0.34 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
In the present study, we examined the effect of the KD on the increase of PENK, Fos, Jun, AP-1 DNA-binding activity and JNK gene expression induced by KA in the mouse hippocampus.
Spec (examined) Positive_regulation (increase) of Gene_expression (expression) of JNK in hippocampus associated with hippocampus
16) Confidence 0.34 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.14 Pain Relevance 0.24
B and JNK activation, are both increased in AD tissue and APPswe mice.
Positive_regulation (increased) of Gene_expression (activation) of JNK associated with disease
17) Confidence 0.14 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.63 Pain Relevance 0.24
Inflammatory stimuli activate the three MAPK major pathways: extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK pathways.
Positive_regulation (activate) of Gene_expression (pathways) of c-jun N-terminal kinase associated with inflammatory stimuli
18) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.03 Pain Relevance 0.26
Inflammatory stimuli activate the three MAPK major pathways: extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 MAPK pathways.
Positive_regulation (activate) of Gene_expression (pathways) of JNK associated with inflammatory stimuli
19) Confidence 0.13 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.03 Pain Relevance 0.26
expression in microglia and stimulates AP-1 transcriptional activity through JNK signaling.
Positive_regulation (stimulates) of Gene_expression (expression) of JNK in microglia
20) Confidence 0.07 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.78 Pain Relevance 0

General Comments

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