INT131744

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 7.67
Pain Relevance 6.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
DRG 4
neurons 1
bladder 1
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 40 99.96 Very High Very High Very High
dorsal root ganglion 16 99.96 Very High Very High Very High
Inflammation 215 99.54 Very High Very High Very High
allodynia 26 99.00 Very High Very High Very High
qutenza 46 98.40 Very High Very High Very High
nociceptor 36 97.76 Very High Very High Very High
trigeminal ganglion 3 97.32 Very High Very High Very High
c fibre 59 97.28 Very High Very High Very High
Cold hyperalgesia 8 97.20 Very High Very High Very High
Pain 28 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 80 99.96 Very High Very High Very High
Ganglion Cysts 30 99.96 Very High Very High Very High
INFLAMMATION 226 99.54 Very High Very High Very High
Hyperalgesia 25 97.20 Very High Very High Very High
Hypersensitivity 72 92.56 High High
Nervous System Injury 11 89.52 High High
Inflammatory Pain 22 85.92 High High
Pain 34 85.56 High High
Nociception 49 83.68 Quite High
Targeted Disruption 9 83.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The whole-cell and single channel properties resemble those previously described for TRPA1.
Transcription (described) of TRPA1
1) Confidence 0.68 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17218316 Disease Relevance 0 Pain Relevance 0.07
Interestingly, we also identified a few TRPA1-positive cold-sensitive A?
Transcription (identified) of TRPA1
2) Confidence 0.67 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.79 Pain Relevance 0.81
Firstly, using reverse transcription-polymerase chain reaction, TRPV1 mRNA and TRPA1 mRNA were distinctly detected in the naive GG.
Transcription (detected) of TRPA1 mRNA associated with ganglion cysts
3) Confidence 0.65 Published 2006 Journal Chem. Senses Section Abstract Doc Link 16831854 Disease Relevance 0.74 Pain Relevance 0.38
Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats.
Neg (not) Transcription (levels) of TRPA1 in DRG associated with dorsal root ganglion and qutenza
4) Confidence 0.63 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.28 Pain Relevance 0.68
RESULTS: TRPA1 mRNA was expressed in L6-S1 dorsal root ganglia (DRG) and bladder.
Transcription (expressed) of TRPA1 in bladder
5) Confidence 0.53 Published 2007 Journal Urology Section Body Doc Link 17991581 Disease Relevance 0.08 Pain Relevance 0
TRPA1 has been previously implicated in neuropathic pain based on the observation that TRPA1 mRNA expression was found to be increased in uninjured small diameter TrkA+ neurons in the L4 DRG following L5 SNL, and the time course of this upregulation was correlated with the development of cold hypersensitivity [23].
Transcription (expression) of TRPA1 in neurons associated with hypersensitivity and neuropathic pain
6) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 1.13 Pain Relevance 0.68
In animal models of inflammatory and neuropathic pain, TRPA1 transcripts were up-regulated in dorsal root ganglia.
Transcription (transcripts) of TRPA1 in dorsal root ganglia associated with inflammation and neuropathic pain
7) Confidence 0.53 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.79 Pain Relevance 0.61
In the nearby uninjured L4 DRG, TRPA1 mRNA expression increased in trkA-expressing small-to-medium diameter neurons from the 1st to 14th day after the L5 SNL.
Transcription (expression) of TRPA1 in DRG associated with dorsal root ganglion and eae
8) Confidence 0.52 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16546170 Disease Relevance 1.28 Pain Relevance 1.02
There is no increase in cell size of TRPA1 mRNA-expressing cells after CFA (Obata et al., 2005), indicating that this increased expression does not occur in large A-fibre, low-threshold neurones.
Transcription (expressing) of TRPA1
9) Confidence 0.52 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 0.59 Pain Relevance 0.58
Furthermore, inflammation increases the numbers of neurones expressing TRPA1 mRNA (Obata et al., 2005).
Transcription (expressing) of TRPA1 associated with inflammation
10) Confidence 0.52 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 1.45 Pain Relevance 1.08
Using in situ hybridization histochemistry and immunohistochemistry, we characterized the precise distribution of TRPA1, TRPM8, and TRPV1 mRNAs in the rat dorsal root ganglion (DRG) and trigeminal ganglion (TG) neurons.
Transcription (distribution) of TRPA1 in DRG associated with ganglion cysts, dorsal root ganglion and trigeminal ganglion
11) Confidence 0.49 Published 2005 Journal J. Comp. Neurol. Section Abstract Doc Link 16304633 Disease Relevance 0.53 Pain Relevance 0.56

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