INT131748

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 5.23
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Csad) cellular_component (Csad)
Anatomy Link Frequency
vasculature 1
Csad (Mus musculus)
Pain Link Frequency Relevance Heat
depression 28 100.00 Very High Very High Very High
Glutamate 2 99.18 Very High Very High Very High
Gabapentin 4 99.04 Very High Very High Very High
headache 16 98.96 Very High Very High Very High
Migraine 44 95.00 High High
fifth nerve 1 83.84 Quite High
imagery 2 83.48 Quite High
Pain 8 80.36 Quite High
medulla 1 77.68 Quite High
cva 1 73.20 Quite High
Disease Link Frequency Relevance Heat
Depression 28 100.00 Very High Very High Very High
Hypoxia 3 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 3 99.98 Very High Very High Very High
Headache 44 98.96 Very High Very High Very High
Epilepsy 7 95.20 Very High Very High Very High
Brain Injury 4 94.20 High High
Pressure And Volume Under Development 3 88.68 High High
Appetite Loss 1 81.84 Quite High
Head Trauma 1 81.76 Quite High
Stroke 3 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As Ca(v)2.1 channels modulate CSD susceptibility, we tested gabapentin, which inhibits Ca(v)2.1 through high-affinity binding to its alpha(2)delta subunit, on CSD susceptibility in anesthetized rats.
CSD Binding (binding) of associated with depression and gabapentin
1) Confidence 0.32 Published 2010 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 20588320 Disease Relevance 0.91 Pain Relevance 0.76
Our results indicate that tissue hypoxia associated with CSD is caused by a transient increase in O2 demand exceeding vascular O2 supply.
CSD Binding (associated) of associated with depression and hypoxia
2) Confidence 0.31 Published 2007 Journal Nat. Neurosci. Section Abstract Doc Link 17468748 Disease Relevance 1.28 Pain Relevance 0.42
These results suggest a mechanism, intrinsic to the vasculature, for propagation of vasodilatation associated with CSD.
CSD Binding (associated) of in vasculature associated with depression and increased venous pressure under development
3) Confidence 0.31 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17329631 Disease Relevance 0.69 Pain Relevance 0.43
Scores between 0.7 and 1 were considered as significant to assess the strength of association between the PD and its different items and CSD and FMD.
CSD Binding (association) of
4) Confidence 0.30 Published 2005 Journal Cephalalgia Section Abstract Doc Link 16305599 Disease Relevance 0.52 Pain Relevance 0.43
Elevated extracellular levels of potassium and glutamate might be crucial for the initiation and propagation of CSD.
CSD Spec (might) Binding (propagation) of associated with glutamate
5) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.84 Pain Relevance 1.28

General Comments

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