INT131763

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.45
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gucy1b2) ion binding (Gucy1b2)
Anatomy Link Frequency
spinal nerve 1
sensory neurons 1
nerve 1
Gucy1b2 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 12 99.32 Very High Very High Very High
Eae 6 98.28 Very High Very High Very High
allodynia 3 94.64 High High
sodium channel 6 91.48 High High
Peripheral nerve injury 3 88.64 High High
ectopic activity 3 67.52 Quite High
anesthesia 2 50.00 Quite Low
isoflurane 2 50.00 Quite Low
Spinal cord 1 50.00 Quite Low
Nicotine 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nervous System Injury 18 99.46 Very High Very High Very High
Neuropathic Pain 18 99.32 Very High Very High Very High
Anxiety Disorder 2 93.96 High High
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That increased beta2 subunit expression in sensory neurons after nerve injury is functionally significant, as demonstrated by our finding that the development of mechanical allodynia-like behavior in the SNI model is attenuated in beta2 subunit null mutant mice.
Gene_expression (expression) of beta2 subunit in sensory neurons associated with nervous system injury and allodynia
1) Confidence 0.21 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16306410 Disease Relevance 0.87 Pain Relevance 0.60
To investigate whether the beta2 subunit of VGSCs participates in the generation of neuropathic pain, we used the spared nerve injury (SNI) model in rats to examine beta2 subunit expression in selectively injured (tibial and common peroneal nerves) and uninjured (sural nerve) afferents.
Spec (examine) Gene_expression (expression) of beta2 subunit in nerve associated with nervous system injury and neuropathic pain
2) Confidence 0.18 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16306410 Disease Relevance 0.64 Pain Relevance 0.38
Although injured neurons show the most marked upregulation,beta2 subunit expression is also increased in neighboring non-injured neurons and a similar pattern of changes appears in the spinal nerve ligation model of neuropathic pain.
Gene_expression (expression) of beta2 subunit in spinal nerve associated with eae and neuropathic pain
3) Confidence 0.18 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16306410 Disease Relevance 0.85 Pain Relevance 0.53
METHODS: Young and aged wild-type and mutant mice lacking the beta2 subunit of the nicotinic cholinergic receptor (beta2KO) were anesthetized for 2 h with 2.6% sevoflurane in oxygen and compared with nonanesthetized controls.
Neg (lacking) Gene_expression (lacking) of beta2 subunit
4) Confidence 0.17 Published 2008 Journal Anesthesiology Section Body Doc Link 18946289 Disease Relevance 0.09 Pain Relevance 0
To identify the type of nicotinic receptor involved, we studied the effect of receptor and subtype-specific ligands and genetically engineered mice, which lacked the gene expression for the nicotinic beta2 subunit.
Neg (lacked) Gene_expression (expression) of beta2 subunit
5) Confidence 0.12 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18713901 Disease Relevance 0 Pain Relevance 0

General Comments

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