INT131767

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.87
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CHRNA7) plasma membrane (CHRNA7)
Anatomy Link Frequency
chromaffin cells 1
neural 1
CHRNA7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 21 99.64 Very High Very High Very High
Cannabinoid receptor 1 97.08 Very High Very High Very High
Catecholamine 6 96.96 Very High Very High Very High
cannabis 24 96.16 Very High Very High Very High
Dopamine 13 88.48 High High
alcohol 25 88.44 High High
addiction 61 81.08 Quite High
Nucleus accumbens 1 78.40 Quite High
Calcium channel 17 78.32 Quite High
Codeine 1 73.12 Quite High
Disease Link Frequency Relevance Heat
Disease 2 99.52 Very High Very High Very High
Shock 2 87.60 High High
Drug Dependence 9 81.08 Quite High
Cannabis Dependence 9 77.32 Quite High
Targeted Disruption 2 74.88 Quite High
Nicotine Addiction 19 72.04 Quite High
Post Operative Pain 1 52.28 Quite High
Pain 4 50.00 Quite Low
INFLAMMATION 13 34.16 Quite Low
Apoptosis 2 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These data indicate for the first time that the clonidine-induced increase in punctuate mechanical threshold is mediated via the activation of all but M2 muscarinic receptor subtypes, and via the activation of alpha4beta2 but not alpha7 nicotinic receptor subtypes in a rodent model for human postoperative pain.


Positive_regulation (activation) of alpha7 nicotinic receptor
1) Confidence 0.31 Published 2005 Journal Anesthesiology Section Body Doc Link 16306740 Disease Relevance 0.05 Pain Relevance 0
Current treatments of Alzheimer's disease include the allosteric potentiation of nicotinic acetylcholine receptor (nAChR) response.
Positive_regulation (potentiation) of nicotinic acetylcholine receptor associated with disease
2) Confidence 0.17 Published 2009 Journal ChemMedChem Section Abstract Doc Link 19739198 Disease Relevance 0.10 Pain Relevance 0.11
Of note, CAT is an inhibitory peptide controlling catecholamine release from chromaffin cells and noradrenergic neurons by an autocrine regulatory mechanism, non-competitively blocking the influx of Ca2+ coupled to activation of the nicotinic acetylcholine receptor, as illustrated in Figure 9, but not when triggered by membrane depolarization [32].
Positive_regulation (activation) of nicotinic acetylcholine receptor in chromaffin cells associated with catecholamine
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.09 Pain Relevance 0.22
Specifically, nicotine operates through activation of nicotinic acetylcholine receptor (nAChR) complexes; delta9-THC operates through activation of the neural cannabinoid receptor, CB1R.
Positive_regulation (activation) of nicotinic acetylcholine receptor in neural associated with cannabinoid receptor and nicotine
4) Confidence 0.04 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.63 Pain Relevance 1.14

General Comments

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