INT131773

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 12.01
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (KDR) cytoplasmic membrane-bounded vesicle (KDR) plasma membrane (KDR)
nucleus (KDR) cytoplasm (KDR)
Anatomy Link Frequency
endothelial cells 2
endothelium 1
internal 1
oviduct 1
KDR (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 100.00 Very High Very High Very High
Inflammation 13 94.84 High High
ischemia 1 76.96 Quite High
Angina 1 76.16 Quite High
nud 1 53.44 Quite High
pain pelvic 2 50.04 Quite High
dysesthesia 1 41.68 Quite Low
headache 10 11.88 Low Low
Pain 10 11.48 Low Low
dexamethasone 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 191 99.12 Very High Very High Very High
Ectopic Pregnancy 95 99.02 Very High Very High Very High
Cancer 208 98.68 Very High Very High Very High
Myeloid Leukemia 27 97.82 Very High Very High Very High
Infection 4 97.44 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 169 96.08 Very High Very High Very High
INFLAMMATION 3 94.84 High High
Myelofibrosis 11 94.48 High High
Colon Cancer 14 93.68 High High
Apoptosis 227 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HHV-8 up-regulates the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR in endothelial cells.
Regulation (regulates) of KDR in endothelial cells
1) Confidence 0.49 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 1.10 Pain Relevance 0
These cells are positive for CD34 and KDR superficial markers of endothelial cellular lineage, which is consistent with the hypothesis that they constitute the endothelial progenitor cells.
Regulation (positive) of KDR
2) Confidence 0.44 Published 2007 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 17979688 Disease Relevance 0.57 Pain Relevance 0.11
Vatalanib decreased VEGF levels and VEGFR phosphorylation in AML cells, which showed FLT3 internal tandem reduplications/mutations (ITD), raising the question of the actual targeted tyrosine kinase (VEGFR or flt3).
Regulation (targeted) of VEGFR in internal associated with myeloid leukemia
3) Confidence 0.37 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2902424 Disease Relevance 1.79 Pain Relevance 0
In an attempt to characterize factors affecting production and secretion of VEGF in EP, expression of VEGF mRNA and the VEGF receptors KDR and flt-1 were measured in implanted and non-implanted sites of the oviduct in women with EP41.
Regulation (measured) of KDR in oviduct associated with ectopic pregnancy
4) Confidence 0.26 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.83 Pain Relevance 0.05
This process is governed by an array of growth factors; however, vascular endothelial growth factor (VEGF) and its major receptor in the endothelium, VEGFR2, are predominant regulators of this process [2].
Regulation (regulators) of VEGFR2 in endothelium
5) Confidence 0.26 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2913951 Disease Relevance 0.60 Pain Relevance 0
HHV-8 up-regulates the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR in endothelial cells.
Regulation (regulates) of Flk-1 in endothelial cells
6) Confidence 0.22 Published 2007 Journal BMC Nephrol Section Body Doc Link PMC1852096 Disease Relevance 1.10 Pain Relevance 0
VEGF receptor tyrosine kinase (VEGFR) is another promising target for the treatment of HCC.
Regulation (target) of VEGFR associated with carcinoma
7) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.14 Pain Relevance 0
HCCs are vascularized tumors with high expression of VEGF raising the possibility that agents targeting VEGFR might be of therapeutic value.
Regulation (targeting) of VEGFR associated with cancer
8) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.20 Pain Relevance 0
Sunitinib is an orally-active small molecule tyrosine kinase inhibitor that acts on multiple targets including VEGFR, PDGFR, c-kit and Flt-3.[46] In a phase II, open-label, multicenter study, sunitinib was evaluated as monotherapy in patients with MBC. 64 patients previously treated with an anthracycline and a taxane received sunitinib 50 mg daily in six week cycles, and results showed that 7 patients achieved a partial response with a median duration of 19 weeks giving an ORR of 11%. 3 patients achieved stable disease for greater than 6 months.
Regulation (acts) of VEGFR associated with disease and advanced or metastatic breast cancer
9) Confidence 0.10 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.30 Pain Relevance 0.03
Sunitinib is an orally-active small molecule tyrosine kinase inhibitor that acts on multiple targets including VEGFR, PDGFR, c-kit and Flt-3.[46] In a phase II, open-label, multicenter study, sunitinib was evaluated as monotherapy in patients with MBC. 64 patients previously treated with an anthracycline and a taxane received sunitinib 50 mg daily in six week cycles, and results showed that 7 patients achieved a partial response with a median duration of 19 weeks giving an ORR of 11%. 3 patients achieved stable disease for greater than 6 months.
Regulation (targets) of VEGFR associated with disease and advanced or metastatic breast cancer
10) Confidence 0.10 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 1.30 Pain Relevance 0.03
Combination approaches targeting the VEGF/VEGFR and the PDGF/PDGFR axes are thus very appealing [67].


Regulation (targeting) of VEGFR
11) Confidence 0.09 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.91 Pain Relevance 0.03
Influence of open versus laparoscopically assisted colectomy on soluble vascular endothelial growth factor (sVEGF) and its soluble receptor 1 (sVEGFR1).
Regulation (Influence) of sVEGFR1 associated with anesthesia
12) Confidence 0.02 Published 2005 Journal Inflamm. Res. Section Title Doc Link 16307219 Disease Relevance 0.09 Pain Relevance 0.15

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