INT131788

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Context Info
Confidence 0.67
First Reported 2001
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 87
Total Number 89
Disease Relevance 86.10
Pain Relevance 8.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (NPPB) extracellular region (NPPB) nucleus (NPPB)
cytoplasm (NPPB)
Anatomy Link Frequency
plasma 7
heart 6
coronary artery 3
hypothalamus 2
superior 2
NPPB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 531 100.00 Very High Very High Very High
ischemia 515 99.92 Very High Very High Very High
cva 472 99.72 Very High Very High Very High
Angina 689 99.54 Very High Very High Very High
Catecholamine 80 99.26 Very High Very High Very High
imagery 322 98.84 Very High Very High Very High
cytokine 148 94.64 High High
Inflammatory response 66 93.52 High High
anesthesia 22 89.60 High High
depression 30 86.88 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 608 100.00 Very High Very High Very High
Necrosis 449 100.00 Very High Very High Very High
Thrombosis 83 100.00 Very High Very High Very High
Brain Injury 55 99.96 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 11 99.96 Very High Very High Very High
Coronary Artery Disease 624 99.92 Very High Very High Very High
Coronary Heart Disease 412 99.92 Very High Very High Very High
Sepsis 363 99.90 Very High Very High Very High
Heart Disease 149 99.84 Very High Very High Very High
Pulmonary Embolism 129 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NT-proBNP levels were elevated in patients with myocardial perfusion defects (p<0.001).
Positive_regulation (elevated) of BNP
1) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995735 Disease Relevance 0.64 Pain Relevance 0.08
Patients with elevated plasma BNP levels (>80 pg/mL) had a significantly higher incidence of new heart failure and all-cause mortality than those with a normal plasma BNP level (<or=80 pg/mL).
Positive_regulation (elevated) of BNP in plasma associated with myocardial infarction
2) Confidence 0.67 Published 2007 Journal Angiology Section Abstract Doc Link 17626979 Disease Relevance 1.33 Pain Relevance 0.38
The main observation of this study is that patients with increased clinical signs of organ dysfunction following multiple injury had significantly increased NT-proBNP levels of greater than 200 pg/mL on admission, increasing to greater than 1,600 pg/mL 72 hours after trauma, in comparison with patients with fewer signs of organ dysfunction.
Positive_regulation (increased) of NT-proBNP associated with injury and multiple trauma
3) Confidence 0.60 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 1.21 Pain Relevance 0.08
The correlation of clinical signs of organ dysfunction and increased NT-proBNP levels is absolutely in line with other authors focusing on the predictive value of NT-proBNP in critical illness.
Positive_regulation (increased) of NT-proBNP associated with critical illness
4) Confidence 0.60 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.92 Pain Relevance 0.13
This also is in contrast to Stewart and colleagues, who enrolled patients with TBI and observed an elevation of BNP independent of cardiac function.
Positive_regulation (elevation) of BNP
5) Confidence 0.60 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.76 Pain Relevance 0.09
In the present study, a significant increase of more than 100 pg/mL in NT-proBNP levels was observed on admission in all patients.
Positive_regulation (increase) of NT-proBNP
6) Confidence 0.60 Published 2008 Journal Crit Care Section Body Doc Link PMC2592747 Disease Relevance 0.65 Pain Relevance 0.05
B-Type natriuretic peptide (BNP) and aminoterminal pro-brain natriuretic peptide (NT-proBNP) are believed to correlate with the severity of heart failure symptoms and objective measures of heart function.1-3) The NT-proBNP levels are affected by demographic variables such as age, gender, and ethnicity, and clinical characteristics such as hypertension, atrial fibrillation, and renal function.4-6) Elevated body mass index (BMI) and obesity have been associated with hypertension, insulin resistance and dyslipidemia, and contribute to deleterious hemodynamic and morphologic cardiovascular changes.7-9) Recent studies demonstrated that obesity is associated with decreased levels of NT-proBNP and raised concerns about the diagnostic and prognostic validity of natriuretic peptides in obese patients.10)11) NT-proBNP has been shown to be increased in patients with diabetes mellitus (DM), even in the absence of structural heart disease, and obesity frequently coexists with diabetes.
Positive_regulation (increased) of NT-proBNP in heart associated with natriuresis, diabetes mellitus, insulin resistance, heart disease, hypertension, obesity, arrhythmias 2 under development and myocardial infarction
7) Confidence 0.60 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 2.20 Pain Relevance 0
The blocking profile of NPPB on these mutants showed that the NPPB activation was similar to that of FTS and different from AITC and menthol.
Positive_regulation (activation) of NPPB
8) Confidence 0.60 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20226176 Disease Relevance 0.25 Pain Relevance 0.23
However, elevated BNP appears to lack validity as a biomarker of myocardial dysfunction in sepsis.
Positive_regulation (elevated) of BNP associated with coronary heart disease and sepsis
9) Confidence 0.59 Published 2010 Journal Crit Care Section Body Doc Link PMC2887156 Disease Relevance 1.12 Pain Relevance 0.16
An important additional finding of this study is that NT-proBNP is elevated relatively rapidly after exposure to anthracyclines.
Positive_regulation (elevated) of NT-proBNP
10) Confidence 0.56 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.45 Pain Relevance 0.07
Although it cannot totally be excluded that the increases in NT-proBNP are (partly) caused by volume loading, this is highly unlikely as the infused volumes were low.
Positive_regulation (increases) of NT-proBNP
11) Confidence 0.56 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.31 Pain Relevance 0.04
Additionally, the increase in NT-proBNP was transient as levels had returned to baseline at the subsequent course.
Positive_regulation (increase) of NT-proBNP
12) Confidence 0.56 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.27 Pain Relevance 0.04
It is also known that concomitant kidney failure results in more pronounced elevations of NT-proBNP, especially in patients with an ejection fraction below 35% (Luchner et al. 2005; Masson et al. 2006).
Positive_regulation (elevations) of NT-proBNP in kidney associated with renal failure
13) Confidence 0.56 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.45 Pain Relevance 0.04
This study indicates that at 24 h after each course of anthracyclin chemotherapy as well as after completion of a full chemotherapy regimen, significant increases in serum NT-proBNP are observed.
Positive_regulation (increases) of NT-proBNP
14) Confidence 0.56 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.19 Pain Relevance 0.04
In these anthracyclin-naïve patients, the estimated increase in NT-proBNP was 269% (n = 12; 167–409%, P < 0.0001) at 24 h after the first DXR-course.
Positive_regulation (increase) of NT-proBNP
15) Confidence 0.56 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0 Pain Relevance 0
NT-proBNP is cleaved from proBNP when it is converted into active BNP upon secretion.
Positive_regulation (cleaved) of BNP
16) Confidence 0.49 Published 2008 Journal J Cancer Res Clin Oncol Section Body Doc Link PMC2515587 Disease Relevance 0.29 Pain Relevance 0.04
First, it is possible that the low natriuretic peptide levels in overweight and obese patients reflect less advanced stages of HF compared with lean patients.21) Cardiac cachexia, a state characterized by weight loss and neurohumoral/cytokine activation, is another potential explanation for a low BMI-high BNP association.22) Recent evidence suggests that there may be increased clearance of circulating BNP in obesity because natriuretic peptide clearance receptors are abundant on human adipocytes.23) High levels of BNP could, through their lipolytic effect, be expected to exaggerate the wasting process, which implies that a reduced BNP level in obese HF patients may be related to a decreased level of wasting.
Positive_regulation (levels) of BNP in adipocytes associated with appetite loss, natriuresis, weight loss, obesity, overweight and cytokine
17) Confidence 0.46 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801462 Disease Relevance 2.03 Pain Relevance 0.07
The results demonstrated that NPPB activation was tightly associated with chemical structure.
Positive_regulation (activation) of NPPB
18) Confidence 0.46 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20226176 Disease Relevance 0.11 Pain Relevance 0.09
An auxiliary aim was to evaluate the potential contribution of LV diastolic dysfunction and fluid management to elevation of plasma BNP concentrations in septic shock.


Positive_regulation (elevation) of plasma BNP in plasma associated with cv general 2 under development and coronary heart disease
19) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2887156 Disease Relevance 1.14 Pain Relevance 0.16
Although the predominant pathophysiological process underlying increased circulating levels of NT-proBNP is regional and global impairment of left ventricular systolic or diastolic function leading to increased left ventricular wall stretch, recent studies have suggested that ischemia itself promotes release of BNP [28], [29].
Positive_regulation (increased) of BNP associated with ischemia
20) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995735 Disease Relevance 1.01 Pain Relevance 0.10

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