INT13179

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Context Info
Confidence 0.34
First Reported 1991
Last Reported 2008
Negated 1
Speculated 0
Reported most in Title
Documents 5
Total Number 5
Disease Relevance 0.89
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCY1) small molecule metabolic process (ADCY1) plasma membrane (ADCY1)
nucleus (ADCY1) GTPase activity (ADCY1) transmembrane transport (ADCY1)
Anatomy Link Frequency
embryonic kidney 2
ADCY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 16 100.00 Very High Very High Very High
Opioid 14 100.00 Very High Very High Very High
addiction 5 99.90 Very High Very High Very High
tolerance 6 97.08 Very High Very High Very High
Glutamate receptor 2 96.24 Very High Very High Very High
MU agonist 1 95.12 Very High Very High Very High
antagonist 2 93.52 High High
bradykinin 1 92.24 High High
agonist 1 90.04 High High
Enkephalin 3 89.08 High High
Disease Link Frequency Relevance Heat
Syndrome 2 94.84 High High
Intellectual Impairment 1 93.08 High High
Glioma 1 93.00 High High
Neuroblastoma 2 92.64 High High
Mental Disorders 1 84.96 Quite High
Drug Dependence 1 84.24 Quite High
Pain 1 83.00 Quite High
Bordatella Infection 2 74.08 Quite High
Cognitive Disorder 1 69.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phospholipase C specific inhibitor 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H -pyrrole-2,5-dione (U73122), which did not affect basal and forskolin-stimulated adenylyl cyclase activities, time- and dose-dependently blocked delta-opioid receptor-mediated inhibition of adenylyl cyclase activity, the EC50 (0.5 microM) of which was consistent with that for inhibition of bradykinin-dependent phospholipase C activation (EC50 = 1 microM).
Neg (not) Regulation (affect) of Neg (not) Positive_regulation (forskolin-stimulated) of adenylyl cyclase associated with opioid receptor and bradykinin
1) Confidence 0.34 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9543254 Disease Relevance 0.25 Pain Relevance 0.16
Role of extracellular signal-regulated kinases in opioid-induced adenylyl cyclase superactivation in human embryonic kidney 293 cells.
Regulation (Role) of Positive_regulation (superactivation) of adenylyl cyclase in embryonic kidney associated with opioid
2) Confidence 0.25 Published 2001 Journal Neurosci. Lett. Section Title Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.67
Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase.
Regulation (Regulation) of Positive_regulation (stimulation) of adenylyl cyclase associated with opioid receptor
3) Confidence 0.15 Published 1995 Journal J. Neurochem. Section Title Doc Link 7760050 Disease Relevance 0.13 Pain Relevance 0.86
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.
Regulation (Roles) of Positive_regulation (calcium-stimulated) of adenylyl cyclase associated with glutamate receptor
4) Confidence 0.01 Published 2008 Journal J. Neurosci. Section Title Doc Link 18434517 Disease Relevance 0.51 Pain Relevance 0.32
With regard to dependence, an increase in adenylate cyclase activity, and therefore of cyclic AMP levels and certain protein kinase activities, have been claimed to be responsible for this phenomenon in some cell types.
Regulation (responsible) of Positive_regulation (increase) of cyclase associated with addiction
5) Confidence 0.01 Published 1991 Journal Clin Neuropharmacol Section Abstract Doc Link 1663419 Disease Relevance 0 Pain Relevance 1.07

General Comments

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