INT131791

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Nub1) cellular_component (Nub1) biological_process (Nub1)
Anatomy Link Frequency
nerve 1
Nub1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 90.52 High High
corticosteroid 24 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 1 91.52 High High
Insulin Resistance 20 50.00 Quite Low
Diabetes Mellitus 5 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Metabolic Syndrome 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The estimated kBS of 0.0436 h?
Positive_regulation (estimated) of kBS
1) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0.09 Pain Relevance 0
Bs-Tx28 which is weakly active in both, mammals and insects (LD(50) 0.088 and 14.3microg/g, respectively), shows strong induction of the rat afferent nerve discharge in a dose-dependent fashion (EC(50)=0.01microg/mL) which was completely abolished in the presence of tetrodotoxin suggesting the binding of Bs-Tx28 to the TTX-sensitive Na(+)-channel.
Positive_regulation (active) of Bs-Tx28 in nerve associated with tetrodotoxin
2) Confidence 0.03 Published 2006 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 16309623 Disease Relevance 0 Pain Relevance 0.09

General Comments

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