INT131818

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 8.74
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
poly 3
brain 1
finger 1
telomere 1
kidney 1
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 70 100.00 Very High Very High Very High
cytokine 26 100.00 Very High Very High Very High
Hyperalgesia 4 99.90 Very High Very High Very High
mu opioid receptor 13 97.68 Very High Very High Very High
Multiple sclerosis 63 91.92 High High
agonist 2 86.32 High High
COX-2 inhibitor 4 76.00 Quite High
headache 1 74.88 Quite High
Morphine 2 62.72 Quite High
dexamethasone 2 54.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 73 100.00 Very High Very High Very High
Hyperalgesia 4 99.90 Very High Very High Very High
Aging 4 99.76 Very High Very High Very High
Lung Injury 204 99.62 Very High Very High Very High
Apoptosis 159 99.16 Very High Very High Very High
Cancer 214 98.74 Very High Very High Very High
Urological Neuroanatomy 18 98.42 Very High Very High Very High
Injury 38 98.04 Very High Very High Very High
Stress 23 97.26 Very High Very High Very High
Genomic Instability 15 96.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, oxidative stress from activated neutrophils was measured indirectly by MPO activity in BALF and the activity was increased in the VILI group and closely associated with PARP activity.
PARP Binding (associated) of in neutrophils associated with lung injury, stress and urological neuroanatomy
1) Confidence 0.46 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.92 Pain Relevance 0.03
One key question derived from the previous results concern the functional consequences of the interaction between PARP-1 and ATM and between poly (ADP-ribosyl)ation and ATM on ATM activation.
PARP-1 Binding (interaction) of in poly
2) Confidence 0.37 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.07 Pain Relevance 0
This poly(ADP-ribosyl)ation activity of PARP-1 appears to be important for maintaining genomic integrity [9] and it has been associated with longevity.
PARP-1 Binding (associated) of in poly associated with aging
3) Confidence 0.37 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.10 Pain Relevance 0
Chromatin immunoprecipitation assays showed specific binding of PARP-1 to the double-stranded poly(C) element essential for the MOR promoter.
PARP-1 Binding (specific) of in poly associated with mu opioid receptor
4) Confidence 0.36 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.64
Correlations of PARP activity with inflammatory cytokines and nuclear factor-kappa-B DNA-binding activity and the effects of PJ34
PARP Binding (binding) of associated with inflammation and cytokine
5) Confidence 0.36 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 1.12 Pain Relevance 0.16
PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers.
PARP-1 Binding (recognize) of
6) Confidence 0.35 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
PARP-1 and ATM recognize and bound to both single and double strand DNA breaks in response to different triggers.
PARP-1 Binding (bound) of
7) Confidence 0.35 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
Additional immunofluorescence studies of tumor tissue after in vivo administration of biotinylated mAb indicated that tumor-bound DAB4 was intimately related to cells containing cleaved PARP1, which is recognized as a marker of late apoptosis (Al-Ejeh et al, accompanying manuscript).
PARP1 Binding (recognized) of associated with cancer and apoptosis
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645682 Disease Relevance 1.13 Pain Relevance 0
PARP is a zinc-finger DNA-binding enzyme that detects DNA strand breaks generated by genotoxic agents such as oxygen radicals.
PARP Binding (binding) of in finger
9) Confidence 0.20 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.24 Pain Relevance 0
High-affinity PARP-1
PARP-1 Binding (affinity) of
10) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2683338 Disease Relevance 0.81 Pain Relevance 0.39
Since PARP inhibition counteracts several organs damage caused by I/R injury, such as brain, kidney and the heart, further studies are required to determine whether inhibition of PARP could attenuate bladder apoptosis.
PARP Neg (inhibition) Binding (inhibition) of in brain associated with injury and apoptosis
11) Confidence 0.09 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 1.24 Pain Relevance 0
We examined whether nitric oxide (NO), derived from constitutive NO synthase (NOS) and/or inducible NOS (iNOS), could contribute to endotoxin-induced inflammatory hyperalgesia via interacting with nuclear factor-kappaB (NF-kappaB), inducible cyclooxygenase (COX-2) and/or polyADP-ribose synthase (PARS).
polyADP-ribose synthase Binding (interacting) of associated with hyperalgesia and inflammation
12) Confidence 0.09 Published 2006 Journal Pharmacol. Res. Section Abstract Doc Link 16310374 Disease Relevance 0.44 Pain Relevance 0.46
PARP has been recognized to play multitude roles in DNA damage responses, including DNA repair, maintenance of genomic stability, transcriptional regulation, signaling pathways involving apoptosis, telomere functions, and other multiple cellular functions [15].
PARP Binding (recognized) of in telomere associated with genomic instability and apoptosis
13) Confidence 0.08 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 1.43 Pain Relevance 0.07
CoAA was also shown to associate with DNA-PK regulatory subunit Ku86 and PARP from GH3 cells, suggesting that CoAA may exist as part of a DNA-PK/NCoA6 complex in vivo.
PARP Binding (associate) of in GH3
14) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0 Pain Relevance 0
Since PARP inhibition counteracts several organs damage caused by I/R injury, such as brain, kidney and the heart, further studies are required to determine whether inhibition of PARP could attenuate bladder apoptosis.
PARP Neg (inhibition) Binding (inhibition) of in kidney associated with injury and apoptosis
15) Confidence 0.03 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967004 Disease Relevance 1.24 Pain Relevance 0

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