INT131822

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 0.33
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 104 99.62 Very High Very High Very High
antagonist 10 85.16 High High
fluoxetine 1 81.36 Quite High
Serotonin 1 72.00 Quite High
imagery 16 23.76 Low Low
Angina 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 25 95.40 Very High Very High Very High
Targeted Disruption 32 50.84 Quite High
Hypertension 32 5.00 Very Low Very Low Very Low
Thrombosis 24 5.00 Very Low Very Low Very Low
Atherosclerosis 24 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Coronary Artery Disease 8 5.00 Very Low Very Low Very Low
Muscular Spasm 8 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, 5-HT has a potent enhancing action on migration of HAECs through activating the RhoA and ERK pathways following 5-HT1 receptor stimulation.
Positive_regulation (following) of Positive_regulation (activating) of RhoA
1) Confidence 0.45 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16310780 Disease Relevance 0.10 Pain Relevance 0.20
While SIN-1 and Cicaprost significantly impaired U46619-mediated RhoA activation in the presence of the siRNA directed to Lamin A/C to levels similar to that in vehicle-treated cells, the inhibitory action of both agents on RhoA activation and cofilin phosphorylation in 1° h.AoSMCs exposed to the siRNATP?
Positive_regulation (mediated) of Positive_regulation (activation) of RhoA
2) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.05 Pain Relevance 0
RhoA activation through GPCRs predominantly occurs by coupling to G12 (G?
Positive_regulation (occurs) of Positive_regulation (activation) of RhoA
3) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
also mediated rapid RhoA activation in HEK.TP?
Positive_regulation (mediated) of Positive_regulation (activation) of RhoA
4) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
, the NO donor SIN-1 specifically impaired U46619-mediated RhoA activation in h.AoSMCs to levels greater than that observed in vehicle treated cells.
Positive_regulation (mediated) of Positive_regulation (activation) of RhoA
5) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
While the IP agonist Cicaprost did not lead to substantial RhoA activation and cofilin phosphorylation relative to the drug vehicle per se, it significantly impaired such U46619-mediated signaling in 1° h.AoSMCs (Fig. 7A).
Neg (not) Positive_regulation (lead) of Positive_regulation (activation) of RhoA associated with agonist
6) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
RhoA activation through GPCRs predominantly occurs by coupling to G12 (G?
Positive_regulation (through) of Positive_regulation (activation) of RhoA
7) Confidence 0.36 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
activation to mobilize Ca2+ from IP3-operated intracellular stores, for example, and to G12-dependent RhoA activation and effector coupling leading to cofilin phosphorylation and inactivation and to F-actin polymerization.


Positive_regulation (dependent) of Positive_regulation (activation) of RhoA
8) Confidence 0.33 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.06 Pain Relevance 0
contribute to RhoA activation, our findings support the hypothesis that TP?
Positive_regulation (contribute) of Positive_regulation (activation) of RhoA
9) Confidence 0.33 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0

General Comments

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