INT131824

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.90
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
Anatomy Link Frequency
monocytes 1
endothelial cells 1
band 1
HPAF-II 1
MDCK 1
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 98.70 Very High Very High Very High
Opioid 3 97.60 Very High Very High Very High
fluoxetine 1 96.80 Very High Very High Very High
cytokine 5 96.52 Very High Very High Very High
Inflammation 13 96.12 Very High Very High Very High
Serotonin 1 92.12 High High
opiate 1 75.00 Quite High
Morphine 4 65.32 Quite High
agonist 30 47.68 Quite Low
mu opioid receptor 1 46.76 Quite Low
Disease Link Frequency Relevance Heat
Clostridium Infection 2 99.58 Very High Very High Very High
Adhesions 12 99.44 Very High Very High Very High
Breast Cancer 3 98.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 110 97.72 Very High Very High Very High
INFLAMMATION 8 96.12 Very High Very High Very High
Viral Meningitis 18 93.56 High High
Stress 10 86.64 High High
Cancer 145 80.92 Quite High
Adenocarcinoma 103 77.60 Quite High
Malignant Neoplastic Disease 14 75.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The purpose of the present study was to investigate whether 5-hydroxytryptamine (5-HT, serotonin) affects migration of vascular endothelial cells. 5-HT significantly enhanced migration of human aortic endothelial cells (HAECs), and this enhancement was completely inhibited by GR 55562, a 5-HT1 receptor antagonist, and fluoxetine, a 5-HT transporter inhibitor, but was not affected by ketanserin, a 5-HT2 receptor antagonist. 5-HT stimulation increased RhoA and ERK activity of HAECs, and inhibitors of RhoA (Y-27632 and H-1152) and inhibitors of MEK (U0126 and PD98059) abolished the 5-HT-induced increase in migration velocity.
Negative_regulation (inhibitors) of RhoA in endothelial cells associated with antagonist, serotonin and fluoxetine
1) Confidence 0.57 Published 2005 Journal FEBS Lett. Section Abstract Doc Link 16310780 Disease Relevance 0.09 Pain Relevance 0.24
For instance, NO reportedly inhibits calcium sensitization by PKG-mediated inhibition of RhoA [34]–[35] and telokin [36], as well as by inhibition of RhoA activation through protein kinase A (PKA)-dependent phosphorylation of G?
Negative_regulation (inhibition) of RhoA
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.05 Pain Relevance 0
Taken together, these results indicate that MNTX inhibits opioid-induced EC proliferation and migration via inhibition of VEGF receptor phosphorylation/transactivation with subsequent inhibition of RhoA activation.
Negative_regulation (inhibition) of RhoA associated with opioid
3) Confidence 0.35 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0 Pain Relevance 0.49
Whilst phosphorylation of RhoA at Ser188 does not apparently alter its association with either RhoGEFs or RhoGAPs (GTPase activating proteins), it significantly increases its interaction with RhoGDI (GDP dissociation inhibitor) thereby reducing the level of membrane bound RhoA and impairing its ability to activate its key effectors including Rho Kinases [36,46].
Negative_regulation (impairing) of RhoA
4) Confidence 0.31 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
All images of RhoA expression/pulldown or cofilin phosphorylation and/or expression were captured using Adobe Photoshop (V6), where band width and intensity was quantified and represented as fold increases relative to basal levels.
Negative_regulation (pulldown) of RhoA in band
5) Confidence 0.30 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
C3 exotransferase is a toxin derived from Clostridium botulinum and is effective at inhibiting RhoA, -B and -C activity with virtually no effect on Rac1 or Cdc42 [34,35].
Negative_regulation (inhibiting) of RhoA associated with clostridium infection
6) Confidence 0.19 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.18 Pain Relevance 0
Again, as a positive control HPAF-II cells were treated with C3 exotransferase; this reduced RhoA activity an average of 63%.
Negative_regulation (reduced) of RhoA in HPAF-II
7) Confidence 0.14 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.18 Pain Relevance 0
For example, although podoplanin can induce RhoA activation and an epithelial-mesenchymal transition (EMT) in MDCK cells [29], it attenuated RhoA activity and could not induce EMT in a breast carcinoma cell line [27], suggesting that podoplanin exerts cell type-specific functions.
Negative_regulation (attenuated) of RhoA in MDCK associated with breast cancer
8) Confidence 0.11 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2987985 Disease Relevance 0.91 Pain Relevance 0
We recently showed that OSM plays a role in regulating the degradation of the small GTPase RhoA and that the CCM endothelial phenotype can be rescued with knockdown or inhibitors of ROCK-RhoA effectors [67].
Negative_regulation (inhibitors) of RhoA
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
in HBMECs can suppress the activity of Rho GTPases (Rac1 and RhoA) and inhibit adhesion and transendothelial migration of HIV-1 infected monocytes [123].


Negative_regulation (suppress) of RhoA in monocytes associated with acquired immune deficiency syndrome or hiv infection and adhesions
10) Confidence 0.06 Published 2010 Journal Retrovirology Section Body Doc Link PMC2864195 Disease Relevance 1.49 Pain Relevance 0.18

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