INT131847

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.38
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 1 79.52 Quite High
Intractable pain 1 77.28 Quite High
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 28 96.28 Very High Very High Very High
Cancer 32 92.84 High High
Adenocarcinoma 51 88.56 High High
Adhesions 1 81.44 Quite High
Spinal Cord Compression 1 80.00 Quite High
Paralysis 1 78.44 Quite High
Bone Fracture 1 77.88 Quite High
Intractable Pain 1 77.28 Quite High
Reprotox - General 1 1 75.00 Quite High
Recurrence 1 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RhoC inhibition, either pharmacologically with C3 exotransferase or molecularly through expression of a dominant-negative RhoC, promotes IGF-I stimulated random motility but decreases in vitro invasion and experimental metastases.
Negative_regulation (inhibition) of Gene_expression (expression) of RhoC associated with metastasis
1) Confidence 0.39 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.12 Pain Relevance 0.12
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
Negative_regulation (decreased) of Gene_expression (expression) of RhoC
2) Confidence 0.31 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0

General Comments

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