INT131848

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Context Info
Confidence 0.64
First Reported 2000
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 15.43
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
Anatomy Link Frequency
HPAF-II 3
PC-3 2
BxPC-3 1
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 181 100.00 Very High Very High Very High
Chronic pancreatitis 10 97.88 Very High Very High Very High
Spinal cord 2 90.60 High High
Intractable pain 2 88.36 High High
cytokine 18 25.32 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
fibrosis 5 5.00 Very Low Very Low Very Low
COX2 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Breast Neoplasms 754 100.00 Very High Very High Very High
Cancer 406 99.96 Very High Very High Very High
Adenocarcinoma 258 99.82 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 78 99.72 Very High Very High Very High
INFLAMMATION 114 99.62 Very High Very High Very High
Adhesions 8 99.60 Very High Very High Very High
Stress 6 99.10 Very High Very High Very High
Malignant Neoplastic Disease 15 98.92 Very High Very High Very High
Breast Cancer 146 98.64 Very High Very High Very High
Pancreatic Cancer 35 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of RhoC GTPase is linked to enhanced metastatic potential in multiple cancers; however, the role of RhoC GTPase in CaP metastasis has not been addressed.
Positive_regulation (Increased) of Gene_expression (expression) of RhoC associated with cancer and metastasis
1) Confidence 0.64 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.16 Pain Relevance 0.13
Using quantitative RT-PCR, however, we found RhoC overexpression only in three of 32 inflammatory breast tumor samples [17].
Positive_regulation (overexpression) of Gene_expression (overexpression) of RhoC associated with inflammation and breast cancer
2) Confidence 0.59 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.43 Pain Relevance 0.21
LIBC was underexpressed in 80% of IBC samples versus 21% in non-inflammatory LABC samples, and RhoC was overexpressed in 90% and 36%, respectively [35].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of RhoC associated with inflammatory breast neoplasms, inflammation and advanced or metastatic breast cancer
3) Confidence 0.59 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.59 Pain Relevance 0.22
In PC tumors, RhoC was overexpressed 3- to 6-fold compared to normal and 2- to 4-fold compared with chronic pancreatitis (Craig Logsdon, personal communication) [31].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of RhoC associated with adenocarcinoma, cancer and chronic pancreatitis
4) Confidence 0.57 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.57 Pain Relevance 0.20
RhoC was overexpressed and found in primary tumors that were locally invasive and in tumors from a variety of metastatic sites [30].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of RhoC associated with cancer
5) Confidence 0.57 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.67 Pain Relevance 0.15
These data suggest that RhoC inhibition leads to activation of other GTPases involved in nondirected motility and that expression of active RhoC is required for the invasive phenotype of PC-3 cells.
Positive_regulation (required) of Gene_expression (expression) of RhoC in PC-3
6) Confidence 0.46 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 0.81 Pain Relevance 0.09
Only two genes, RhoC GTPase and the lost in inflammatory breast cancer gene LIBC (also known as WISP3), were respectively overexpressed and underexpressed in inflammatory versus stage III non-inflammatory breast tumor samples by in situ hybridization [35].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of RhoC associated with inflammation and breast cancer
7) Confidence 0.43 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.69 Pain Relevance 0.26
Figure 2B is a comparison of RhoC expression and activation in the BxPC-3 and HPAF-II cell lines.
Positive_regulation (activation) of Gene_expression (expression) of RhoC in HPAF-II
8) Confidence 0.41 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.42 Pain Relevance 0
RhoC GTPase is overexpressed in aggressive cancers that metastasize and is the predominant GTPase in PC.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of RhoC associated with adenocarcinoma and cancer
9) Confidence 0.41 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 1.11 Pain Relevance 0
In addition to increased stress fiber and focal adhesion contact formation, over-expression of RhoC could activate other Rho family members (ie RhoA, rac and/or cdc42) through signaling feedback loops [39], leading to dynamic cytoskeletal reorganization and a motile/metastatic cell.
Positive_regulation (activate) of Gene_expression (over) of RhoC associated with stress and adhesions
10) Confidence 0.39 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.17 Pain Relevance 0.03
Transfection and over-expression of RhoC GTPase in Epstein-Barr virus-immortalized HME cells produce highly motile and invasive tumorigenic clones (van Golen et al, unpublished data).
Positive_regulation (over) of Gene_expression (expression) of RhoC
11) Confidence 0.37 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.04 Pain Relevance 0.03
Transfection of Aplysia Rho (which is 92% homologous to human RhoC) into NIH3T3 cells led to malignant transformation of the cells [37].
Positive_regulation (Transfection) of Gene_expression (Transfection) of RhoC associated with malignant neoplastic disease
12) Confidence 0.34 Published 2000 Journal Breast Cancer Res Section Body Doc Link PMC138665 Disease Relevance 1.35 Pain Relevance 0.04
Figure 2B is a comparison of RhoC expression and activation in the BxPC-3 and HPAF-II cell lines.
Positive_regulation (activation) of in BxPC-3 Gene_expression (expression) of RhoC in HPAF-II
13) Confidence 0.14 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.42 Pain Relevance 0

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