INT131849

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 6.46
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RHOC) signal transduction (RHOC) plasma membrane (RHOC)
nucleus (RHOC) intracellular (RHOC) GTPase activity (RHOC)
Anatomy Link Frequency
HPAF-II 7
PC-3 1
RHOC (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 3 79.72 Quite High
Intractable pain 3 77.48 Quite High
Inflammation 22 51.00 Quite High
Chronic pancreatitis 22 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 268 99.92 Very High Very High Very High
Adhesions 3 98.28 Very High Very High Very High
Adenocarcinoma 561 96.92 Very High Very High Very High
Clostridium Infection 11 94.56 High High
Cancer 344 93.04 High High
Spinal Cord Compression 3 80.20 Quite High
Paralysis 3 78.64 Quite High
Bone Fracture 3 78.08 Quite High
Intractable Pain 3 77.48 Quite High
Pancreatic Cancer 77 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of RhoC activity results in drastic morphologic changes and alterations in the expression and distribution of focal adhesion-related proteins.
Negative_regulation (Inhibition) of RhoC associated with adhesions
1) Confidence 0.54 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.04 Pain Relevance 0.10
These data suggest that RhoC inhibition leads to activation of other GTPases involved in nondirected motility and that expression of active RhoC is required for the invasive phenotype of PC-3 cells.
Negative_regulation (inhibition) of RhoC in PC-3
2) Confidence 0.54 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 0.90 Pain Relevance 0.09
RhoC inhibition, either pharmacologically with C3 exotransferase or molecularly through expression of a dominant-negative RhoC, promotes IGF-I stimulated random motility but decreases in vitro invasion and experimental metastases.
Negative_regulation (inhibition) of RhoC associated with metastasis
3) Confidence 0.54 Published 2006 Journal Oncogene Section Abstract Doc Link 16314838 Disease Relevance 1.11 Pain Relevance 0.12
C3 exotransferase treatment reduced active RhoC levels by 85%.
Negative_regulation (reduced) of RhoC
4) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
Figure 3A shows a 57% decrease of active RhoC in the HPAF-II/dnRhoC transfectants compared with the untransfected and vector transfected controls.
Negative_regulation (decrease) of RhoC in HPAF-II
5) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
High cav-1 protein expression leads to inhibition of RhoC activation while inhibition of RhoC activity leads to partial re-expression of cav-1.
Negative_regulation (inhibition) of RhoC
6) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.09 Pain Relevance 0
In the HPAF-II/dnRhoC cells, the overall phospho-p42/p44 levels were higher compared with the parental HPAF-II cell line suggesting that inhibition of RhoC leads to increased Erk activation.
Negative_regulation (inhibition) of RhoC in HPAF-II
7) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0.03
As shown in Figure 3C, inhibition of RhoC activity, either by dnRhoC or by treatment with C3 exotransferase, significantly reduced HPAF-II cell migration by nearly 4-fold (p = 0.001) and invasion by 3-fold (p = 0.023), suggesting a key role for RhoC GTPase mediating HPAF-II cell migration and invasion.


Negative_regulation (inhibition) of RhoC in HPAF-II
8) Confidence 0.36 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.21 Pain Relevance 0
Furthermore, inhibition of RhoC or p38 activity in HPAF-II cells leads to partial restoration of cav-1 expression.


Negative_regulation (inhibition) of RhoC in HPAF-II
9) Confidence 0.36 Published 2005 Journal Mol Cancer Section Abstract Doc Link PMC1173138 Disease Relevance 1.04 Pain Relevance 0
Therefore, RhoC activity was specifically decreased in the HPAF-II cells expressing dominant negative RhoC.
Negative_regulation (decreased) of RhoC in HPAF-II
10) Confidence 0.36 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.20 Pain Relevance 0
Furthermore, RhoC activity was appreciably reduced in the SB220025 treated HPAF-II cells strengthening the notion that cav-1 is in a reciprocal relationship with RhoC and p38 activity.


Negative_regulation (reduced) of RhoC in HPAF-II
11) Confidence 0.36 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.24 Pain Relevance 0
Inhibition of RhoC or p38 activation results in decreased cellular movement and partial re-expression cav-1 protein.
Negative_regulation (Inhibition) of RhoC
12) Confidence 0.36 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.75 Pain Relevance 0
Unexpectedly, the association between cav-1 and RhoC was restored in the HPAF-II/dnRhoC cell line suggesting that inhibition of RhoC activity leads to re-expression of cav-1 protein.
Negative_regulation (inhibition) of RhoC in HPAF-II
13) Confidence 0.35 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.14 Pain Relevance 0
Compared with the controls, transient ectopic re-expression of cav-1 decreased levels of active RhoC by 6-fold without effecting total RhoC protein levels, suggesting regulation of RhoC activation by cav-1.
Negative_regulation (decreased) of RhoC
14) Confidence 0.31 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0

General Comments

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